Perirhinal cortex and temporal lobe epilepsy [PDF]
Frontiers in Cellular Neuroscience, 2013 The perirhinal cortex – which is interconnected with several limbic structures and is intimately involved in learning and memory - plays major roles in pathological processes such as the kindling phenomenon of epileptogenesis and the spread of limbic ...
Giuseppe eBiagini +6 more
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Putting objects in context: A prefrontal–hippocampal–perirhinal cortex network [PDF]
Brain and Neuroscience Advances, 2020 When we encounter an object, we spontaneously form associations between the object and the environment in which it was encountered. These associations can take a number of different forms, which include location and context.
G. R. I. Barker, E. C. Warburton
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Excellent Interrater Reliability for Manual Segmentation of the Medial Perirhinal Cortex [PDF]
Brain Sciences, 2023 Objective: Evaluation of interrater reliability for manual segmentation of brain structures that are affected first by neurofibrillary tau pathology in Alzheimer’s disease.
Nicolas A. Henzen +4 more
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Perirhinal cortex and the recognition of relative familiarity [PDF]
Neurobiology of Learning and Memory, 2021 Spontaneous object recognition (SOR) is a widely used task of recognition memory in rodents which relies on their propensity to explore novel (or relatively novel) objects. Network models typically define perirhinal cortex as a region required for recognition of previously seen objects largely based on findings that lesions or inactivations of this ...
Ameen-Ali, Kamar E. +5 more
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Endocytosis is required for consolidation of pattern-separated memories in the perirhinal cortex [PDF]
Frontiers in Systems Neuroscience, 2023 IntroductionThe ability to separate similar experiences into differentiated representations is proposed to be based on a computational process called pattern separation, and it is one of the key characteristics of episodic memory.
Dinka Piromalli Girado +4 more
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A critical role for long-term potentiation mechanisms in the maintenance of object recognition memory in perirhinal cortex revealed by the infusion of zeta inhibitory pseudosubstrate [PDF]
Frontiers in Behavioral Neuroscience, 2022 Object recognition, the ability to discriminate between a novel and a familiar stimulus, is critically dependent upon the perirhinal cortex. Neural response reductions upon repetition of a stimulus, have been hypothesized to be the mechanism within ...
Alexandra R. Outram +3 more
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Infusing zeta inhibitory peptide into the perirhinal cortex of rats abolishes long-term object recognition memory without affecting novel object location recognition [PDF]
Frontiers in Behavioral Neuroscience, 2022 Infusing the amnesic agent zeta inhibitory peptide (ZIP) into the dorsal hippocampus disrupts established long-term object location recognition memory without affecting object identity recognition, which likely depends on the perirhinal cortex.
Keanan Augereau +2 more
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Integrating Visual and Tactile Information in the Perirhinal Cortex [PDF]
Cerebral Cortex, 2009 By virtue of its widespread afferent projections, perirhinal cortex is thought to bind polymodal information into abstract object-level representations. Consistent with this proposal, deficits in cross-modal integration have been reported after perirhinal lesions in nonhuman primates.
Holdstock, J +4 more
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Male rodent perirhinal cortex, but not ventral hippocampus, inhibition induces approach bias under object-based approach-avoidance conflict [PDF]
eLife, 2023 Neural models of approach-avoidance (AA) conflict behavior and its dysfunction have focused traditionally on the hippocampus, with the assumption that this medial temporal lobe (MTL) structure plays a ubiquitous role in arbitrating AA conflict.
Sandeep S Dhawan +3 more
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Perirhinal Cortex Learns A Predictive Map of The Task Environment [PDF]
Nature Communications, 2023 ABSTRACT Goal-directed tasks involve acquiring an internal model, known as a predictive map, of relevant stimuli and associated outcomes to guide behavior. Here, we identified neural signatures of a predictive map of task behavior in perirhinal cortex (Prh). Mice learned to perform a tactile working memory task by classifying sequential
David G. Lee +9 more
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