Excellent Interrater Reliability for Manual Segmentation of the Medial Perirhinal Cortex [PDF]
Brain Sciences, 2023 Objective: Evaluation of interrater reliability for manual segmentation of brain structures that are affected first by neurofibrillary tau pathology in Alzheimer’s disease.
Nicolas A. Henzen +4 more
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A critical role for long-term potentiation mechanisms in the maintenance of object recognition memory in perirhinal cortex revealed by the infusion of zeta inhibitory pseudosubstrate [PDF]
Frontiers in Behavioral Neuroscience, 2022 Object recognition, the ability to discriminate between a novel and a familiar stimulus, is critically dependent upon the perirhinal cortex. Neural response reductions upon repetition of a stimulus, have been hypothesized to be the mechanism within ...
Alexandra R. Outram +3 more
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Endocytosis is required for consolidation of pattern-separated memories in the perirhinal cortex [PDF]
Frontiers in Systems Neuroscience, 2023 IntroductionThe ability to separate similar experiences into differentiated representations is proposed to be based on a computational process called pattern separation, and it is one of the key characteristics of episodic memory.
Dinka Piromalli Girado +4 more
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Infusing zeta inhibitory peptide into the perirhinal cortex of rats abolishes long-term object recognition memory without affecting novel object location recognition [PDF]
Frontiers in Behavioral Neuroscience, 2022 Infusing the amnesic agent zeta inhibitory peptide (ZIP) into the dorsal hippocampus disrupts established long-term object location recognition memory without affecting object identity recognition, which likely depends on the perirhinal cortex.
Keanan Augereau +2 more
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Putting objects in context: A prefrontal–hippocampal–perirhinal cortex network [PDF]
Brain and Neuroscience Advances, 2020 When we encounter an object, we spontaneously form associations between the object and the environment in which it was encountered. These associations can take a number of different forms, which include location and context.
G. R. I. Barker, E. C. Warburton
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Male rodent perirhinal cortex, but not ventral hippocampus, inhibition induces approach bias under object-based approach-avoidance conflict [PDF]
eLife, 2023 Neural models of approach-avoidance (AA) conflict behavior and its dysfunction have focused traditionally on the hippocampus, with the assumption that this medial temporal lobe (MTL) structure plays a ubiquitous role in arbitrating AA conflict.
Sandeep S Dhawan +3 more
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Perirhinal Cortex LTP Does Not Require Astrocyte BDNF-TrkB Signaling [PDF]
Cells, 2022 Neurons release and respond to brain-derived neurotrophic factor (BDNF) with bursts of brain activity. BDNF action is known to extend to peri-synaptic astrocytes, contributing to synaptic strengthening.
Beatrice Vignoli, Marco Canossa
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Automated segmentation for cortical thickness of the medial perirhinal cortex [PDF]
Scientific ReportsAlzheimer’s disease (AD) is characterized by a progressive spread of neurofibrillary tangles (NFT), beginning in the medial perirhinal cortex (mPRC), advancing to the entorhinal cortex (ERC), and subsequently involving the hippocampus, lateral perirhinal
Nicolas A. Henzen +5 more
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Repeated cocaine exposure during adolescence impairs recognition memory in early adulthood: A role for BDNF signaling in the perirhinal cortex [PDF]
Developmental Cognitive Neuroscience, 2020 The perirhinal cortex (PrhC) is critical for object recognition memory; however, information regarding the molecular mechanisms underlying this type of memory following repeated exposure to drugs of abuse during adolescence is unknown.
Francesca Mottarlini +4 more
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Reconciling the object and spatial processing views of the perirhinal cortex through task-relevant unitization. [PDF]
Hippocampus, 2021 Fiorilli J +5 more
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