Putting objects in context: A prefrontal–hippocampal–perirhinal cortex network [PDF]
Brain and Neuroscience Advances, 2020 When we encounter an object, we spontaneously form associations between the object and the environment in which it was encountered. These associations can take a number of different forms, which include location and context.
Gareth Barker
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Excellent Interrater Reliability for Manual Segmentation of the Medial Perirhinal Cortex [PDF]
Brain Sciences, 2023 Objective: Evaluation of interrater reliability for manual segmentation of brain structures that are affected first by neurofibrillary tau pathology in Alzheimer’s disease.
Nicolas A. Henzen +4 more
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Endocytosis is required for consolidation of pattern-separated memories in the perirhinal cortex [PDF]
Frontiers in Systems Neuroscience, 2023 IntroductionThe ability to separate similar experiences into differentiated representations is proposed to be based on a computational process called pattern separation, and it is one of the key characteristics of episodic memory.
Dinka Piromalli Girado +4 more
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A critical role for long-term potentiation mechanisms in the maintenance of object recognition memory in perirhinal cortex revealed by the infusion of zeta inhibitory pseudosubstrate [PDF]
Frontiers in Behavioral Neuroscience, 2022 Object recognition, the ability to discriminate between a novel and a familiar stimulus, is critically dependent upon the perirhinal cortex. Neural response reductions upon repetition of a stimulus, have been hypothesized to be the mechanism within ...
Alexandra R. Outram +3 more
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Infusing zeta inhibitory peptide into the perirhinal cortex of rats abolishes long-term object recognition memory without affecting novel object location recognition [PDF]
Frontiers in Behavioral Neuroscience, 2022 Infusing the amnesic agent zeta inhibitory peptide (ZIP) into the dorsal hippocampus disrupts established long-term object location recognition memory without affecting object identity recognition, which likely depends on the perirhinal cortex.
Keanan Augereau +2 more
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Male rodent perirhinal cortex, but not ventral hippocampus, inhibition induces approach bias under object-based approach-avoidance conflict [PDF]
eLife, 2023 Neural models of approach-avoidance (AA) conflict behavior and its dysfunction have focused traditionally on the hippocampus, with the assumption that this medial temporal lobe (MTL) structure plays a ubiquitous role in arbitrating AA conflict.
Sandeep S Dhawan +3 more
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Perirhinal Cortex LTP Does Not Require Astrocyte BDNF-TrkB Signaling [PDF]
Cells, 2022 Neurons release and respond to brain-derived neurotrophic factor (BDNF) with bursts of brain activity. BDNF action is known to extend to peri-synaptic astrocytes, contributing to synaptic strengthening.
Beatrice Vignoli, Marco Canossa
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Automated segmentation for cortical thickness of the medial perirhinal cortex [PDF]
Scientific ReportsAlzheimer’s disease (AD) is characterized by a progressive spread of neurofibrillary tangles (NFT), beginning in the medial perirhinal cortex (mPRC), advancing to the entorhinal cortex (ERC), and subsequently involving the hippocampus, lateral perirhinal
Nicolas A. Henzen +5 more
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Repeated cocaine exposure during adolescence impairs recognition memory in early adulthood: A role for BDNF signaling in the perirhinal cortex [PDF]
Developmental Cognitive Neuroscience, 2020 The perirhinal cortex (PrhC) is critical for object recognition memory; however, information regarding the molecular mechanisms underlying this type of memory following repeated exposure to drugs of abuse during adolescence is unknown.
Francesca Mottarlini +4 more
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The piriform, perirhinal, and entorhinal cortex in seizure generation
Frontiers in Neural Circuits, 2015 Understanding neural network behavior is essential to shed light on epileptogenesis and seizure propagation. The interconnectivity and plasticity of the limbic and cortical regions of the mammalian brain provide the substrate for the hypersynchrony and ...
Mohamad Koubeissi +2 more
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