Results 141 to 150 of about 415,778 (252)

Expression of HECTD2 predicts peritoneal metastasis of gastric cancer and reconstructs immune microenvironment

Peritoneal metastasis (PM) is a common metastasis site and death cause of gastric cancer, which is a complex biological process, but there is currently a lack of effective prediction and treatment targets.
Jiayi Huang, Junjie Hang, Libao Gong, Lin Song, Xue Bai, Jinfeng Guo   +5 more
core   +1 more source

Surgical Impact on Postoperative Morbidity in Colorectal Cancer with Peritoneal Metastasis: A Multicenter Prospective Observational Study. [PDF]

J Anus Rectum Colon
Toyota N, Ozawa H, Kobayashi H, Kotake K, Kawasaki M, Kanemitsu Y, Kinugasa Y, Ueno H, Maeda K, Suto T, Sugihara K, Ajioka Y.   +11 more
europepmc   +1 more source

Combining TAG‐72CAR with anti‐MUC16CAR improves the potency of ovarian cancer treatment

The FEBS Journal, EarlyView.
Tz‐KBBCAR, a combinatorial CAR targeting MUC16 and TAG‐72, enhances the precision of ovarian cancer immunotherapy. By requiring both tumour antigens for full activation, Tz‐KBBCAR was designed to eliminate MUC16+/TAG‐72+ cancer cells, while sparing MUC16+/TAG‐72‐ healthy cells.
Alicia Villatoro, Aurore Dougé, Klara Krpina, Lea‐Marie Schmitz, Christopher Forcados, Fatemeh Kaveh, Andrea Estrella Arias‐Díaz, Pascal Gelebart, Emmet McCormack, Renata Stripecke, Miguel Abal, Ben Davidson, Else Marit Inderberg, Sébastien Wälchli   +13 more
wiley   +1 more source

Extraperitoneal single‐site robot‐assisted radical prostatectomy with extended pelvic lymph node dissection: technique and experience

BJU International, Volume 135, Issue 4, Page 700-705, April 2025.
Yubo Wang, Mingzhao Li, Kai Yao, Zhuyinjun Zong, Yifan Chang, Yongda Liu, Chao Cai, Fadi Mousa Al Kalailah, Shancheng Ren, Guohua Zeng, Di Gu   +10 more
wiley   +1 more source

Do alternative classification systems improve prognostication in phyllodes tumours of the breast? A comparative clinicopathological study

Histopathology, EarlyView.
In this cohort, high stromal mitotic activity and malignant heterologous elements best predicted recurrence in breast phyllodes tumours. The WHO 5th Edition showed the strongest correlation with outcomes. Tan et al. showed near‐complete concordance, while the Refined Criteria overclassified malignancy without a clear prognostic refinement.
Yuri Merlotti Gomes, João Pedro dos Reis da Costa, Roberto Bonfim Pimenta Peixoto, João Henrique Quintão, Solange Moraes Sanches, Almir Galvão Vieira Bitencourt, Fabiana Baroni Alves Makdissi, Renato Cagnacci Neto, Guilherme Rocha Melo Gondim, Emílio Marcelo Pereira, Cynthia Aparecida Bueno de Toledo Osório, Helenice Gobbi, Marina De Brot, Rodrigo Fonseca Abreu   +13 more
wiley   +1 more source

Significance of SYT8 For the Detection, Prediction, and Treatment of Peritoneal Metastasis From Gastric Cancer [PDF]

Objective: To develop novel diagnostic and therapeutic targets specific for peritoneal metastasis of gastric cancer (GC). Background: Advanced GC frequently recurs because of undetected micrometastases even after curative resection. Peritoneal metastasis
Kanda, Mitsuro, Iwata, Naoki, Hayashi, Masamichi, Tanaka, Haruyoshi, Yamada, Suguru, Tanaka, Chie, Kobayashi, Daisuke, Niwa, Yukiko, Fujii, Tsutomu, Murotani, Kenta, Shimizu, Dai, Kodera, Yasuhiro, Fujiwara, Michitaka, Sugimoto, Hiroyuki, 78781, 78780, 78783, 78782, 78785, 78784, 78787, 78786, 78789, 78788, 78776, 78778, 78777, 78779   +27 more
core  

Tumour deposits are associated with increased metastatic risk in colorectal cancer: a population‐based analysis of metastatic patterns and burden

Histopathology, EarlyView.
In this population‐based cohort of 3505 patients with colorectal cancer without distant metastases at diagnosis, tumour deposits are independently associated with an increased risk of distant metastases (HR 1.34, 95% CI 1.03–1.74). This finding supports consideration of tumour deposits in future risk stratification strategies.
Yao Shu, Nelleke P M Brouwer, Marloes A G Elferink, Johannes H W de Wilt, Femke Simmer, Iris D Nagtegaal   +5 more
wiley   +1 more source

RHOV Is a Detachment-Responsive Rho GTPase Necessary for Ovarian Cancer Peritoneal Metastasis. [PDF]

Cancer Res
Elhaw AT, Tang PW, Cheng YY, Kamlapurkar S, Javed Z, Al-Saad S, White SR, Abdelnaby AE, Khan H, Choi AS, Mattheyses AL, Cole AR, Kim YS, Atiya HI, Trebak M, Zervantonakis IK, Buckanovich RJ, Aird KM, Coffman LG, Mythreye K, Hempel N.   +20 more
europepmc   +1 more source

Interleukin‐12: Central Roles in Immune Regulation and Disease Therapy

Immunology &Cell Biology, EarlyView.
IL‐12 levels are tightly regulated to balance effective protective immunity against infections and cancer with the risk of excessive inflammation and autoimmune disease. Both insufficient and excessive IL‐12 activity can therefore be detrimental, highlighting the importance of precisely controlling its production and signaling. ABSTRACT Interleukin‐12 (
Anthi Psoma, Geert van den Bogaart
wiley   +1 more source

Analysis of risk factors for peritoneal metastasis in patients with advanced gastric cancer. [PDF]

Medicine (Baltimore)
Su A, Guo R, Meng Y, Li Y, Wu C.
europepmc   +1 more source