Results 81 to 90 of about 62,247 (257)

How the HTAR will contribute to a value‐based decision‐making for medicinal products across the EU

British Journal of Clinical Pharmacology, EarlyView.
The European Union Health Technology Regulation 2021/2282 (HTAR) introduces joint assessment of health technologies (including medicinal products and medical devices) across EU Member States. It was signed into law in 2021 and came into full force in January 2025.
Roisin Adams, Michal Stanak
wiley   +1 more source

N6‐methyladenosine‐regulated exosome biogenesis orchestrates an immunosuppressive pre‐metastatic niche in gastric cancer peritoneal metastasis

Cancer Communications
Background Gastric cancer peritoneal metastasis is clinically challenging, given the limited treatment options and poor prognosis. The molecular mechanisms that precede gastric cancer peritoneal metastasis, known as the pre‐metastatic niche (PMN), and ...
Song Li, Jianyuan Zhou, Shuang Wang, Qian Yang, Shulun Nie, Chunwang Ji, Xue Zhang, Shuhan Li, Xuanyu Zhou, Jiahui Chu, Xuehui Wu, Jianqiao Jiao, Ruitao Xu, Qian Xu, Miao Huang, Qiushi Wang, Liliang Dou, Qinqin Hu, Fan Jiang, Xin Dai, Zhaodi Nan, Xinyu Song, Di Zhang, Lian Liu   +23 more
doaj   +1 more source

Payload‐Based Clinical Pharmacology Review of Approved Antibody–Drug Conjugates: Commonalities and Considerations for Streamlined Development

Clinical Pharmacology &Therapeutics, EarlyView.
Antibody–drug conjugates (ADCs) combine the specificity of an antibody with the potency of a cytotoxic drug. Thirteen ADCs, utilizing seven unique cytotoxic payloads and targeting 11 distinct antigens, are currently approved by the US Food and Drug Administration as of June 2025, representing a rapidly growing and highly promising class of anticancer ...
Sijie Lu, Qingqing Xiao, Lixuan Qian, Siyuan Sun, Zhu Zhou, Michael Z. Liao, Chunze Li   +6 more
wiley   +1 more source

Cytological Features of Clear Cell Sarcoma in Exfoliative and Effusion Cytology Specimen—A Case Report and Literature Review

Diagnostic Cytopathology, EarlyView.
ABSTRACT Clear cell sarcoma of soft tissue (CCSST) with malignant effusion is a rare yet clinically aggressive appearance, which may pose a diagnostic pitfall with its overlapping cytomorphologic features with metastatic melanoma and carcinoma.
William H. Wu, Joanna K. M. Ng, Joshua J. X. Li   +2 more
wiley   +1 more source

Calcitonin gene‐related peptide concentration in cerebrospinal fluid and serum in horses affected by trigeminal‐mediated headshaking

Equine Veterinary Journal, EarlyView.
Abstract Background Trigeminal‐mediated headshaking (TMHS) in horses shares clinical features with human trigeminal neuralgia (HTN). Increased levels of the neuropeptide calcitonin gene‐related peptide (CGRP) have been found in the blood and cerebrospinal fluid (CSF) of HTN patients. Inhibition of CGRP in humans has shown promise for pain relief.
Lisa Annabel Weber, Hilke Oltmanns, Ludovica Chiavaccini, Kirstie J. Pickles, Veronica Roberts, Tanja Kloock, Tobias Niebuhr, Karsten Feige   +7 more
wiley   +1 more source

A New Model Based on Folate Receptor-Positive Circulating Tumor Cells for the Preoperative Prediction of Peritoneal Metastasis in Gastrointestinal Malignancies: A Retrospective Study in China

Gut and Liver
Background/Aims : To construct a new model based on folate receptor-positive circulating tumor cells (FR+-CTC) for the preoperative prediction of peritoneal metastasis in gastrointestinal malignancies and to apply this model in clinical practice. Methods
Dan Li, Can Liu, Renwang Hu
doaj   +1 more source

Editorial: Peritoneal metastasis of gastric cancer

Frontiers in Oncology, 2023
Shuyi Wang, Shuyi Wang, Jialin Song, Jialin Song, Bin Xiong, Bin Xiong   +5 more
openaire   +3 more sources

Development of a prognostic scoring system for systemic inflammatory response syndrome in donkeys

Equine Veterinary Journal, EarlyView.
Abstract Background Systemic inflammatory response syndrome (SIRS) is associated with increased mortality in horses with gastrointestinal (GI) disease. However, there are no data relating to naturally occurring SIRS in donkeys. Objectives To determine SIRS frequency in donkeys with GI disease. To develop a donkey‐specific prognostic SIRS score.
Marine A. Barnabé, Nicholas J. Bamford, Jonathan Elliott, Yu‐Mei Chang, Karen Rickards, Nicola J. Menzies‐Gow   +5 more
wiley   +1 more source

Diagnostic Role of Staging Laparoscopy in the Management of Gastro-Esophageal Junction and Gastric Adenocarcinoma

Pakistan Armed Forces Medical Journal
Objectives: To evaluate the role of staging laparoscopy in the detection of radiological occult peritoneal metastasis in patients with gastro-esophageal junction and gastric adenocarcinoma.
Asra Taj, Ghulam Haider, Batool Memon, Tooba Ather, Hadiya Azam, Moiz Ahmed   +5 more
doaj   +1 more source

Personalized Precision in Healthcare Payment Systems: Insights From a Real‐World Cancer Patients Cohort Study

Health Care Science, EarlyView.
We developed an effective prediction model for reasonably high hospitalization costs, using gastric cancer surgery patients as an example. Integrating this assessment into the healthcare payment system based on diagnosis‐related groups is expected to improve the individualization and precision of health insurance fund utilization.
Kan Xue, Hongrui Tian, Qi Wang, Yinkui Wang, Fei Shan, Yansui Yang, Miao Yu, Zhonghu He, Ziyu Li, Jiafu Ji   +9 more
wiley   +1 more source