Results 81 to 90 of about 415,778 (252)

Metastasis Pattern‐Specific Biomarkers and Therapeutic Targets in Gastric Cancer: From Surgical Specimens to Clinical Translation

Annals of Gastroenterological Surgery, EarlyView.
Gastric cancer metastasis should be considered according to its anatomical route, because lymphatic, peritoneal, and hematogenous dissemination involve partly distinct molecular mechanisms. This review summarizes metastasis pattern‐associated and pattern‐specific molecules identified using surgical specimens, evaluates their evidence and translational ...
Mitsuro Kanda
wiley   +1 more source

Refining OVCAR‐3 xenograft models of peritoneal carcinomatosis in nu/nu mice: Comparative intraperitoneal implantation strategies and the role of basement membrane matrix

Animal Models and Experimental Medicine, EarlyView.
A refined murine model of advanced ovarian cancer was established by comparing localized preperitoneal implantation and intraperitoneal injection of OVCAR‐3Luc cells. While localized implantation showed limited tumor persistence, intraperitoneal delivery with BME produced sustained diffuse dissemination confirmed by BLI and histology, providing a ...
M. Teresa Perelló‐Trias, Antonio Jose Serrano‐Muñoz, Juan J. Segura‐Sampedro, Adriana M. Quintero‐Duarte, Joana M. Ramis, Marta Monjo   +5 more
wiley   +1 more source

CD90+ mesothelial-like cells in peritoneal fluid promote peritoneal metastasis by forming a tumor permissive microenvironment. [PDF]

, 2014
The peritoneal cavity is a common target of metastatic gastrointestinal and ovarian cancer cells, but the mechanisms leading to peritoneal metastasis have not been fully elucidated.
Toshiaki Watanabe, Shigenobu Emoto, Hironori Ishigami (512049), Toshiaki Watanabe (512050), Hironori Yamaguchi, Shigenobu Emoto (512047), Joji Kitayama (55603), Joji Kitayama, Hironori Yamaguchi (512048), Hironori Ishigami, Yamaguchi Hironori, Kitayama Joji, Ishigami Hironori, Watanabe Toshiaki, Emoto Shigenobu   +14 more
core   +1 more source

Hubungan Metastasis Peritoneal dengan Kejadian Asites pada Kanker Ovarium di Bagian Obstetri dan Ginekologi RSUP Dr M Djamil Padang [PDF]

, 2019
Latar Belakang : Kanker ovarium merupakan keganasan ginekologi paling mematikan didunia. Kanker ovarium memiliki kecendrungan untuk bermetastasis pada daerah abdomen terutama kavitas peritoneal.
Cyntia, Harkhansa
core   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Peritoneal metastasis after emergency hepatectomy and delayed hepatectomy for spontaneous rupture of hepatocellular carcinoma

, 2019
Summary: Background and objectives: Delayed hepatectomy is the preferred approach for spontaneous rupture of resectable hepatocellular carcinoma (HCC). However, delayed surgery for ruptured HCC may increase the risk of peritoneal metastasis.
Lei Ji, Shiqiao Luo, Xin Yi, Jinyao Liang, Jianming Wang, Ao Ren, Shunyuan Wan   +6 more
core   +1 more source

In Vivo CRISPR Screening Identifies the Glutamate Receptor GRIA2 as Promoting Peritoneal Metastasis of Gastric Cancer via Calcium‐Dependent β‐Catenin Activation

Advanced Science
Peritoneal metastasis is the most lethal manifestation of gastric cancer, with a median survival of less than one year, highlighting the need for new therapeutic targets.
Jie Sun, Xu Yang, Wenchao Jiang, Chengbo Ji, Yingying Wu, Haoyu Sun, Xinyou Liu, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Junjie Zhao, Yuanyuan Ruan, Haojie Li, Xuefei Wang   +13 more
doaj   +1 more source

How the HTAR will contribute to a value‐based decision‐making for medicinal products across the EU

British Journal of Clinical Pharmacology, EarlyView.
The European Union Health Technology Regulation 2021/2282 (HTAR) introduces joint assessment of health technologies (including medicinal products and medical devices) across EU Member States. It was signed into law in 2021 and came into full force in January 2025.
Roisin Adams, Michal Stanak
wiley   +1 more source

Extracellular Vesicles‐Based Biological Macromolecule Delivery Systems: Biogenesis, Characterization, and Emerging Clinical Applications

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu, Zeynep Betül Sarı, Muhammed Emin Sarı, Erdi Can Aytar   +3 more
wiley   +1 more source

Mechanisms of Metastasis in Colorectal Cancer and Metastatic Organotropism: Hematogenous versus Peritoneal Spread [PDF]

, 2019
Metastasis is the major cause of death in patients with colorectal carcinoma (CRC). The most common sites of metastasis are the liver and the peritoneum.
Boesch, F., Guba, M., Werner, J., Angele, M., Bazhin, A., Neumann, J., Pretzsch, E., Ganschow, P.   +7 more
core   +1 more source