Results 51 to 60 of about 43,516 (333)

The Precapillary Segment of the Blood-Brain Barrier and Its Relation to Perivascular Drainage in Alzheimer's Disease and Small Vessel Disease.

The Scientific World Journal, 2009
The blood-brain barrier (BBB) is the border between the brain tissue and the blood and consists of a pre- and post-capillary and a capillary segment. At capillaries protein transport is possible via receptor-mediated endocytosis through endothelial cells.
Dietmar R. Thal
doaj   +1 more source

Cerebral Vessels: An Overview of Anatomy, Physiology, and Role in the Drainage of Fluids and Solutes

Frontiers in Neurology, 2021
The cerebral vasculature is made up of highly specialized structures that assure constant brain perfusion necessary to meet the very high demand for oxygen and glucose by neurons and glial cells.
Nivedita Agarwal, Nivedita Agarwal, Nivedita Agarwal, Roxana Octavia Carare   +3 more
doaj   +1 more source

Fibrinogen triggers perivascular fibroblast activation in the perivascular space in a mouse model of cortical ischemic stroke [PDF]

Fibrotic scar formation is a persistent repair response within a lesion following Central Nervous System (CNS) disease. Perivascular fibroblasts (PVFs) located in the perivascular space delaminate from blood vessels, expand and become an integral ...
Martínez Santamaría, Jose Carlos
core   +1 more source

Giant perivascular space:a rare cause of acute neurosurgical emergency [PDF]

, 2023
We present a rare case of giant perivascular space in mesencephalo-thalamic region causing hydrocephalus. The patient presented insidiously over 6 months.
Torgersen, Antonia, Elmaadawi, Ibrahim, Abdelrahman, Mohamed, Rajendra, Jayesh, Thirumurthi, Tharikeshwari, Kanodia, Avinash Kumar, Hossain-Ibrahim, Kismet   +6 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

3D Segmentation of Perivascular Spaces on T1-Weighted 3 Tesla MR Images With a Convolutional Autoencoder and a U-Shaped Neural Network

Frontiers in Neuroinformatics, 2021
We implemented a deep learning (DL) algorithm for the 3-dimensional segmentation of perivascular spaces (PVSs) in deep white matter (DWM) and basal ganglia (BG).
Philippe Boutinaud, Philippe Boutinaud, Ami Tsuchida, Ami Tsuchida, Ami Tsuchida, Alexandre Laurent, Alexandre Laurent, Alexandre Laurent, Filipa Adonias, Filipa Adonias, Filipa Adonias, Zahra Hanifehlou, Zahra Hanifehlou, Victor Nozais, Victor Nozais, Victor Nozais, Victor Nozais, Violaine Verrecchia, Violaine Verrecchia, Violaine Verrecchia, Violaine Verrecchia, Leonie Lampe, Junyi Zhang, Yi-Cheng Zhu, Christophe Tzourio, Christophe Tzourio, Bernard Mazoyer, Bernard Mazoyer, Bernard Mazoyer, Bernard Mazoyer, Bernard Mazoyer, Marc Joliot, Marc Joliot, Marc Joliot, Marc Joliot   +34 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source