Results 71 to 80 of about 5,273,568 (326)

Enlarged perivascular spaces are associated with white matter injury, cognition and inflammation in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy

Brain Communications
Enlarged perivascular spaces have been previously reported in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, but their significance and pathophysiology remains unclear.
N. Karvelas, Bradley C Oh, Earnest Y Wang, Y. Cobigo, T-H Tsuei, Stephen Fitzsimons, Kyan Younes, Alexander Ehrenberg, M. Geschwind, Daniel Schwartz, Joel H. Kramer, A. Ferguson, Bruce L. Miller, Lisa C Silbert, H. Rosen, F. Elahi   +15 more
semanticscholar   +1 more source

Association Between Enlarged Perivascular Spaces and Cognition in a Memory Clinic Population

Neurology, 2022
Background and Objectives Although enlarged perivascular spaces (EPVS) have been suggested as an emerging measure of small vessel disease (SVD) in the brain, their association with cognitive impairment is not yet clearly understood.
Y. Choe, H. Baek, H. Choi, M. Byun, D. Yi, B. Sohn, C. Sohn, D. Y. Lee   +7 more
semanticscholar   +1 more source

The Brain Endothelial Cell Glycocalyx Plays a Crucial Role in the Development of Enlarged Perivascular Spaces in Obesity, Metabolic Syndrome, and Type 2 Diabetes Mellitus

Life, 2023
The brain endothelial cell (BEC) glycocalyx (ecGCx) is a BEC surface coating consisting of a complex interwoven polysaccharide (sweet husk) mesh-like network of membrane-bound proteoglycans, glycoproteins, and glycosaminoglycans (GAGs) covering the ...
Melvin R. Hayden
doaj   +1 more source

Enlarged perivascular spaces, neuroinflammation and neurological dysfunction in NMOSD patients

Frontiers in Immunology, 2022
Background and objectives Cerebrospinal fluid (CSF) and interstitial fluid exchange along a brain-wide network of perivascular spaces (PVS) termed the ‘glymphatic system’.
Xiaobao Yao, Meichun Gao, Shuwei Bai, L. Xie, Yahui Song, Jie Ding, Yifan Wu, Chunran Xue, Yong Hao, Ying Zhang, Yang-Tai Guan   +10 more
semanticscholar   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

Perivascular spaces are associated with tau pathophysiology and synaptic dysfunction in early Alzheimer’s continuum

Alzheimer's Research & Therapy, 2021
Perivascular spaces (PVS) have an important role in the elimination of metabolic waste from the brain. It has been hypothesized that the enlargement of PVS (ePVS) could be affected by pathophysiological mechanisms involved in Alzheimer’s disease (AD ...
N. Vilor-Tejedor, Iacopo Ciampa, G. Operto, C. Falcón, M. Suárez‐Calvet, M. Crous-Bou, M. Shekari, E. Arenaza‐Urquijo, M. Milà-Alomà, O. Grau-Rivera, C. Minguillón, Gwendlyn Kollmorgen, H. Zetterberg, K. Blennow, R. Guigó, J. Molinuevo, J. Gispert, Annabella Anna Raffaele Alba Carme Irene Ruth Maria Karine S Beteta Brugulat Cacciaglia Cañas Deulofeu Cumplido, Annabella Beteta, A. Brugulat, R. Cacciaglia, Alba Cañas, C. Deulofeu, Irene Cumplido, Ruth Domínguez, Maria Emilio, K. Fauria, Sherezade Fuentes, Laura Hernández, Gema Huesa, J. Huguet, P. Marne, Tania Menchón, A. Polo, Sandra Pradas, B. Rodríguez‐Fernández, A. Sala-Vila, G. Sánchez-Benavides, Gemma Salvadó, Anna Soteras, M. Vilanova   +40 more
semanticscholar   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

Semi-automated Segmentation and Quantification of Perivascular Spaces at 7 Tesla in COVID-19

Frontiers in Neurology, 2022
While COVID-19 is primarily considered a respiratory disease, it has been shown to affect the central nervous system. Mounting evidence shows that COVID-19 is associated with neurological complications as well as effects thought to be related to ...
Mackenzie T. Langan, Derek A. Smith, G. Verma, Oleksandr Khegai, S. Saju, S. Rashid, D. Ranti, Matthew Markowitz, P. Belani, N. Jette, B. Mathew, J. Goldstein, C. Kirsch, L. Morris, Jacqueline Becker, B. Delman, P. Balchandani   +16 more
semanticscholar   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source