Results 91 to 100 of about 5,273,568 (326)

Advancing Age Modulates Associations Between Cognitive Impairment and Brain Volumes in Early MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Cognitive impairment is common in multiple sclerosis (MS), but manifestations following the first demyelinating event are relatively unexplored. We investigated cross‐sectional associations between magnetic resonance imaging (MRI)–derived brain volumes and the presence of cognitive impairment outcomes five years after the first ...
Piriyankan Ananthavarathan, Marco Pitteri, Michael Foster, Sara Collorone, Sara Salama, Elisa Colato, Ferran Prados, Baris Kanber, Marios Yiannakas, Claudia A. M. Gandini Wheeler‐Kingshott, Indran Davagnanam, Frederik Barkhof, Declan Chard, Olga Ciccarelli, Ahmed Toosy   +14 more
wiley   +1 more source

Perivascular spaces, glymphatic dysfunction, and small vessel disease [PDF]

, 2017
Cerebral small vessel diseases (SVDs) range broadly in etiology but share remarkably overlapping pathology. Features of SVD including enlarged perivascular spaces (EPVS) and formation of abluminal protein deposits cannot be completely explained by the ...
Mehta, Rupal I., Humberto Mestre, Rupal I. Mehta, Serhii Kostrikov, Kostrikov, Serhii, Maiken Nedergaard, Nedergaard, Maiken, Mestre, Humberto   +7 more
core   +1 more source

Structure and function of the perivascular fluid compartment and vertebral venous plexus: Illumining a novel theory on mechanisms underlying the pathogenesis of Alzheimer's, cerebral small vessel, and neurodegenerative diseases

Neurobiology of Disease, 2020
Blood dynamically and richly supplies the cerebral tissue via microvessels invested in pia matter perforating the cerebral substance. Arteries penetrating the cerebral substance derive an investment from one or two successive layers of pia mater ...
Michael George Zaki Ghali, Vitaliy Marchenko, M. Gazi Yaşargil, George Zaki Ghali   +3 more
doaj   +1 more source

Flash Assembloids: A Rapid Biofabrication of a Platform for Modeling Early Glioblastoma Invasion at the Glioblastoma–Brain Organoid Interfaces

Advanced Healthcare Materials, EarlyView.
This study presents a bioengineered assembloid (ASM) system combining glioblastoma (GBM) cells in oxidized alginate (OA) microgels with dorsal organoids (DOs). This model simulates brain tumor‐host interactions, revealing enhanced GBM invasion, altered gene expression, and aggressive infiltration patterns, demonstrating ASM as a valuable platform for ...
Chao Liang, Henry Robert Howard, Shihui Chen, Won‐Young Choi, Summer Cao, Arthur Chien, Kevin Zou, Michael Kassiou, Fabien Delerue, Ho Sang Jung, Yeonju Park, Young Mee Jung, Yong‐Dae Kwon, Karrie M. Kiang, Gilberto Ka‐Kit Leung, Ryohichi Sugimura, Ann‐Na Cho, Sang Jin Lee   +17 more
wiley   +1 more source

Enlarged perivascular spaces as an MRI marker of pathology-proven cerebral amyloid angiopathy [PDF]

, 2022
Enlarged perivascular spaces as an MRI marker of pathology-proven cerebral amyloid ...
D Werring (13553734), P Varlet (13445289), M Burnell (13445286), Z Jaunmuktane (13746820), S Brandner (13746823), A Charidimou (13445172), J Xuereb (13445292), Anna Peeters (13058832), J-C Baron (13553830), H R Jaeger (13553824)   +9 more
core  

A Novel Perfused Full‐Thickness Human Skin Microphysiological System for Modeling Injury, Regeneration, Tumor Pathophysiology, and Therapeutics Development

Advanced Healthcare Materials, EarlyView.
What if human skin could remain fully alive and functional outside the body for weeks? A New Alternative Method (NAM) based on a vascularized full‐thickness skin microphysiological system achieves precisely this, preserving native vasculature, resident immunity, and metabolic activity for up to three weeks, while faithfully recapitulating radiation ...
Yusuf Surucu, Hamid Malekzadeh, Alexa Rivera Del Rio Hernandez, Naresh Mahajan, Ethan Banks, Dayyan Ur Rahman, José A. Arellano, Katherine S. Yang, Alexey Altman, G.V. Naveen Kumar, Matthew L. Steinhauser, Jeffrey A. Gusenoff, J. Peter Rubin, Asim Ejaz   +13 more
wiley   +1 more source

The ivy sign

South African Journal of Radiology, 2014
The ivy sign refers to diffuse bilateral leptomeningeal enhancement on post- contrastT1-weighted magnetic resonance imaging (MRI) and increased signal intensity in bilateralsubarachnoid spaces and perivascular spaces on T2-weighted fluid attenuation ...
Nasreen Mahomed, Evance Chisama, Sanjay Prabhu   +2 more
doaj   +1 more source

Magnetic resonance imaging findings of the posterior fossa in 47 patients with mucopolysaccharidoses: A cross‐sectional analysis

JIMD Reports, 2021
Background Mucopolysaccharidoses (MPS) is a group of hereditary multisystemic lysosomal disorders. Most neuroimaging studies in MPS have focused on the supratentorial compartment and craniocervical junction abnormalities, and data regarding posterior ...
Roberta Reichert, Juliano A. Pérez, Amauri Dalla‐Corte, Filippo Pinto e Vairo, Carolina F. M. deSouza, Roberto Giugliani, Gustavo R. Isolan, Marco Antonio Stefani   +7 more
doaj   +1 more source

Case report: A multiple sclerosis patient with imaging features of glymphatic failure benefitted from CSF flow shunting

Frontiers in Neuroscience, 2022
The derangement of CSF circulation impacts the functions of the glymphatic-lymphatic system (G-Ls), which regulates solute trafficking and immune surveillance in the CNS.
Antonio Scollato, Francesco Lolli, Francesco Lolli, Giancarlo Lastrucci, Anna Repice, Giuseppe De Santis, Claudio Nicoletti, Berardino Porfirio, Pasquale Gallina, Pasquale Gallina   +9 more
doaj   +1 more source

Automatic quantification of perivascular spaces in T2-weighted images at 7 T MRI

Cerebral Circulation - Cognition and Behavior, 2022
Highlights • Fully automated detection of perivascular spaces on 7T MRI.• Good correlation with manual assessments of perivascular spaces.• Quantitative measurements of PVS characteristics: density, length, and tortuosity.
J. Spijkerman, J. Zwanenburg, W. Bouvy, M. Geerlings, G. Biessels, J. Hendrikse, P. Luijten, H.J. Kuijf   +7 more
semanticscholar   +1 more source