Results 111 to 120 of about 5,273,568 (326)

Mitochondrial Carrier SLC25A13 Drives Ferroptosis Resistance and Immune Evasion via a STAT3–IFI6 Circuit in Breast Cancer

Advanced Science, EarlyView.
SLC25A13 is identified as an immunometabolic driver of triple‐negative breast cancer that sustains ferroptosis resistance and immune evasion through a STAT3–IFI6 circuit. Pharmacologic degradation of SLC25A13 restores ferroptosis sensitivity and enhances anti‐PD‐1 efficacy, highlighting a strategy to convert immune‐cold tumors into immunotherapy ...
Yingze Zhu, Yuhan Tang, Yingcui Chen, Zhuoqi Zhang, Yige Lu, Xinyue Wang, Qiyuan Shi, Wenhui Zhao, Hui Pang   +8 more
wiley   +1 more source

RNF138‐Mediated Ubiquitination and Degradation of NS5 Restricts Tick‐Borne Encephalitis Virus Infection

Advanced Science, EarlyView.
Host‐specific compatibility between RNF138‐like proteins and flavivirus NS5 determines NS5 stability. Mammalian RNF138 but not arthropod homologs recognizes and induces conserved NS5/RdRp K48‐linked ubiquitination and proteasomal degradation, thereby restricting viral replication. Ectopic RNF138 in mice attenuates TBEV‐induced pathogenesis. (Created in
Jialiang Sun, Weijing Yang, Hao Zhou, Shuai Li, Xin Jiang, Jianyang Gu, Wenyan Zhang   +6 more
wiley   +1 more source

A Small Trinucleotide Expansion in the TBP Gene Gives Rise to a Sporadic Case of SCA17 with Abnormal Putaminal Findings on MRI [PDF]

, 2008
A Japanese woman developed gait disturbances at 25 years of age, and subsequently underwent gradual changes in her personality. By the age of 42, she showed clear signs of dementia and cerebellar ataxia, and displayed behavioral abnormalities, choreic ...
Suzuki, Chieko, Tomiyama, Masahiko, Jackson, Mandy, Ikeda, Yoshio, Yamamoto-Watanabe, Yukiko, Watanabe, Mitsunori, Kawarabayashi, Takeshi, Shoji, Mikio, Wakasaya, Yasuhito, Monai, Natsuki, Kimura, Tamaki, Miki, Yasuo, Matsubara, Etsuro, Seino, Yusuke   +13 more
core   +1 more source

Placental Site Trophoblastic Tumor Acquires Immune Functions by Incorporating Host Maternal Genes

Advanced Science, EarlyView.
PSTT cells, through cell fusion with B cells, incorporate abundant non‐inherited maternal genes that are detectable by DNIMA. These hybrid cells acquire immunotherapy‐resistant genetic changes and increase the expression of B cell‐derived immune‐related molecules such as Ig, HLA, LILRB, SIGLEC10, and so on, creating an immunotolerant environment around
Kyosuke Kagami, Masanori Ono, Yasunari Mizumoto, Tatsuhito Kanda, Takashi Iizuka, Takiko Daikoku, Shin‐ichi Horike, Akira Hattori, Akihito Horie, Sachiko Minamiguchi, Tomoko Fujiwara, Kazuyoshi Hosomichi, Atsushi Tajima, Hirokazu Usui, Kaoru Abiko, Hiroshi Fujiwara   +15 more
wiley   +1 more source

A new mechanism for glymphatic flow of interstitial fluid in branched perivascular spaces of the brain [PDF]

, 2023
Objective. To explore the biophysics of interstitial tissue fluid flow in the brain, based upon the anatomy and mechanics of the perivascular spaces, in order to better understand how glymphatic flow happens. Methods.
Babbs, Charles F
core   +1 more source

Hemoglobin's α‐Helix‐to‐β‐Sheet Transition Enables Targeted mRNA Delivery to the Lung

Advanced Science, EarlyView.
Acidic heating converts hemoglobin into β‐sheet‐rich fibrils with positively charged surfaces. These hemoglobin fibrils electrostatically complex IL‐11 scFv mRNA, selectively bind circulating platelets, and hitchhike to the lung, where they are enriched in fibroblasts.
Xihua Liu, Saiya Li, Guodong Wu, Shuangjian Li, Long Shuang Huang, Xiaoyang Li, Yiguo Zhao, Wei Lu, Cuixia Sun, Qin Cao, Yapeng Fang, Yiping Cao   +11 more
wiley   +1 more source

Extensive Perivascular Spaces in the Centrum Semiovale: A Diagnostic Pitfall

Indian Journal of Neurosurgery
Enlarged Virchow–Robin spaces are benign perivascular fluid-filled structures that may occasionally mimic pathological intracranial lesions on imaging. We report a 55-year-old male who presented with intermittent dizziness and was found to have extensive
Adrian Jamesraj Jacob, Saranraj M.K, Balamurugan Mangaleswaran   +2 more
doaj   +1 more source

Targeting Lipopolysaccharide Transport Induces Membrane Lipid Remodeling and Sensitizes Acinetobacter baumannii to Colistin Treatment

Advanced Science, EarlyView.
This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo, Hetianzi Zhang, Jinju Cai, Shuang Zhou, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
wiley   +1 more source

Supplemental Material - Enlarging and shrinking focal perivascular spaces [PDF]

Supplemental Material for Enlarging and shrinking focal perivascular spaces by Alexandre Boutet, Hyo Jin Son, Mikail Malik, Samuel Haile, Andrew Z Yang, Vivek Pai, Jurgen Germann, and Daniel M Mandell in The Neuroradiology Journal.
Samuel Haile (18296391), Jurgen Germann (10797200), Alexandre Boutet (12044819), Vivek Pai (228059), Andrew Z Yang (18296394), Hyo Jin Son (16620114), Daniel M Mandell (18296397), Mikail Malik (18296388)   +7 more
core   +1 more source

Automated Quantification of Enlarged Perivascular Spaces in Clinical Brain MRI Across Sites [PDF]

, 2019
Enlarged perivascular spaces (PVS) are structural brain changes visible in MRI, and are a marker of cerebral small vessel disease. Most studies use time-consuming and subjective visual scoring to assess these structures.
Marleen de Bruijne, Skalej, Martin, Vernooij, Meike, Meike Vernooij, Max Dünnwald, Wiro Niessen, Martin Skalej, Dubost, Florian, Steffen Oeltze-Jafra, Vincent Scheumann, Oeltze-Jafra, Steffen, Niessen, Wiro, Stefanie Schreiber, Dünnwald, Max, Schreiber, Stefanie, Frank Schreiber, Schreiber, Frank, de Bruijne, Marleen, Scheumann, Vincent, Denver Huff, Florian Dubost, Huff, Denver   +21 more
core   +1 more source