Results 121 to 130 of about 5,273,568 (326)

Quality Thresholds for Angiogenesis Under Acoustic Manipulation in Engineered Vascular Tissues

Advanced Science, EarlyView.
Defined biological and physical quality thresholds achieved through acoustic manipulation regulate cellular alignment and spatial organization, promoting self‐assembling vasculature, extracellular matrix deposition, and angiogenic responses, thereby establishing critical acoustic patterning requirements for engineered vascular tissue development in ...
Oscar O'Dwyer Lancaster‐Jones, Russell Quinn, Niloofar Khoshdel Rad, Kilian Paul, Andrea Frank, Daniela F. Duarte Campos   +5 more
wiley   +1 more source

Depletion of B lymphocytes from cerebral perivascular spaces by rituximab. [PDF]

, 2009
BACKGROUND: Rituximab is a recombinant chimeric monoclonal antibody against CD20, a molecule expressed on cells of the B-cell lineage. A phase 2 clinical trial recently provided strong evidence of the beneficial effects of rituximab in patients with ...
Martin, Mdel P;Cravens, PD;Winger, R;Kieseier, BC;Cepok, S;Eagar, TN;Zamvil, SS;Weber, MS;Frohman, EM;Kleinschmidt-DeMasters, BK;Montine, TJ;Hemmer, B;Marra, CM;Stüve, O
core   +1 more source

Eye‐Brain Neuroimmune Axis Enables Long‐Term Survival in Glioblastoma by Modulating Brain Immune Surveillance and Neuronal Excitability

Advanced Science, EarlyView.
The eye–brain neuroimmune axis triggers immune activation and disrupts pathological neuronal connectivity to extend glioblastoma survival. ABSTRACT As an anatomical extension of the central nervous system (CNS), the eye harbors rich neural and immune interfaces with the brain. However, the integrated immunological and neurological nexus between the eye
Mingyue Cui, Lulu Qian, Binbin Chu, Xuan Qin, Menglin Wu, Minke Wu, Tongyu He, Baochuan Zhang, Bin Song, Yao He   +9 more
wiley   +1 more source

Matrix Stiffness Induces Endothelial Network Senescence

Advanced Science, EarlyView.
Using a 3D human in vitro model that decouples mechanical stress from inflammatory or biochemical signals, matrix stiffening induces a senescence phenotype in endothelial networks. This mechano‐induced senescence activates Notch signaling, and pharmacologic Notch inhibition attenuates this stiffness‐induced senescence.
Jiyeon Song, Alexandra N. Rindone, Ya Guan, Connor D. Amelung, Prarthana Sanjay Daswani, Jennifer H. Elisseeff, Sharon Gerecht   +6 more
wiley   +1 more source

Comparison of MR signal intensities of cerebral perivascular (Virchow-Robin) and subarachnoid spaces [PDF]

, 2002
Purpose: The purpose of this work was to compare quantitatively the T2-weighted MR signal intensity values of the perivascular (Virchow-Robin) spaces and the cerebrospinal fluid (CSF)
AYDINGÖZ, ÜSTÜN, Ozturk, MH
core   +1 more source

Transient but not chronic hyperglycemia accelerates ocular glymphatic transport

Fluids and Barriers of the CNS
Glymphatic transport is vital for the physiological homeostasis of the retina and optic nerve. Pathological alterations of ocular glymphatic fluid transport and enlarged perivascular spaces have been described in glaucomatous mice.
Christine Delle, Xiaowei Wang, Michael Giannetto, Evan Newbold, Weiguo Peng, Ryszard Stefan Gomolka, Antonio Ladrón-de-Guevara, Neža Cankar, Elise Schiøler Nielsen, Celia Kjaerby, Pia Weikop, Yuki Mori, Maiken Nedergaard   +12 more
doaj   +1 more source

The Configuration of the Perivascular System Transporting Macromolecules in the CNS

Frontiers in Neuroscience, 2019
Large blood vessels entering the CNS are surrounded by perivascular spaces that communicate with the cerebrospinal fluid and, at their termini, with the interstitial space.
Beata Durcanova, Janine Appleton, Nyshidha Gurijala, Vasily Belov, Vasily Belov, Vasily Belov, Pilar Giffenig, Elisabeth Moeller, Matthew Hogan, Fredella Lee, Mikhail Papisov, Mikhail Papisov, Mikhail Papisov   +12 more
doaj   +1 more source

Longitudinal Single‐Axon‐Resolution Imaging of Peripheral Nerve Injury Response in Mice Using an Optical Window Implant

Advanced Science, EarlyView.
A minimally invasive optical window enables stable, long‐term imaging of peripheral nerves in vivo at single‐axon resolution. Dynamic processes of degeneration, regeneration, and cellular remodeling are visualized across multiple time scales within the same nerve region, providing a unique platform to study a variety of anatomical and molecular events ...
Igor D. Luzhansky, Emma Anisman, Ron Perez, Sophia Zhang, Morgan Hoffman, Daniel Hunter, Abigail Cherian, Jevon Bonner, Emilia Feria, Ahmed Ahmed, Muneeb Malik, Junwei Du, Leland C. Sudlow, David M. Brogan, Matthew D. Wood, Mikhail Y. Berezin   +15 more
wiley   +1 more source

Giant Tumefactive Perivascular Spaces Mimicking a Brain Mass Lesion: Report of Three Cases [PDF]

, 2019
Virchow–Robin spaces or perivascular spaces are pial-lined fluid-filled interstitial spaces recognized throughout brain parenchyma along the path of penetrating vessels.
Elena Prodi, Elisa Ventura, Fabio Rinaldi, Alessandro Cianfoni   +3 more
core   +1 more source

HD‐tDCS Restores Perivascular AQP4 Polarization via PPARγ Modulation to Enhance Glymphatic Clearance After Intracerebral Hemorrhage in Mice

Advanced Science, EarlyView.
HD‐tDCS promotes recovery after intracerebral hemorrhage by enhancing PPARγ‐dependent astrocyte remodeling in a mouse model of ICH. This process suppresses proinflammatory astrocytic activation, restores perivascular AQP4 repolarization, and improves glymphatic influx and efflux, thereby facilitating hematoma and perihematomal edema clearance and ...
Zhiming Li, Yingmei Zhang, Qianqian Tong, Zhitao Gong, Shanyu Zhang, Zhen Qian, Hui Zhang, Qian Yao, Qi Li   +8 more
wiley   +1 more source