Results 101 to 110 of about 5,273,568 (326)

Perivascular Matrix Densification Dysregulates Angiogenesis and Activates Pro‐Inflammatory Endothelial Cells

Advanced Science, EarlyView.
Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia, William Y. Wang, Kyle A. Jacobs, Kairav Maniar, Daphne Lin, Evan H. Jarman, Daniel L. Matera, Kristen Loesel, Christopher D. Davidson, Harrison L. Hiraki, Xiaotian Tan, Eve H. Shikanov, Robert N. Kent, Carole Parent, Xudong Fan, Ariella Shikanov, Matthew L. Kutys, Brendon M. Baker   +17 more
wiley   +1 more source

Change in Enlarged Perivascular Spaces over Time and Associations with Outcomes After Traumatic Brain Injury

Neurotrauma Reports
Enlarged perivascular spaces (EPVs) can be seen on magnetic resonance imaging (MRI) scans in various neurological diseases, including traumatic brain injury (TBI).
Alexa E. Walter, Krupa Savalia, Jason Yoon, Justin Morrison, Andrea L. C. Schneider, Ramon Diaz-Arrastia, Danielle K. Sandsmark   +6 more
doaj   +1 more source

Disproportionate subarachnoid space hydrocephalus—outcome and perivascular space [PDF]

Annals of Clinical and Translational Neurology, 2014
AbstractObjectiveWe sought to identify the prevalence of MRI features of disproportionately enlarged subarachnoid space hydrocephalus in possible idiopathic normal pressure hydrocephalus (DESH‐iNPH) and to describe the clinico‐radiological features and outcomes of a community‐based investigation (The Vienna Trans‐Danube Aging study).MethodsOf the 697 ...
Akiguchi, Ichiro, Shirakashi, Yoshitomo, Budka, Herbert, Watanabe, Yuko, Watanabe, Toshiyuki, Shiino, Akihiko, Ogita, Mihoko, Kawamoto, Yasuhiro, Jungwirth, Susanne, Krampla, Wolfgang, Fischer, Peter   +10 more
openaire   +2 more sources

Asymmetric distribution of enlarged perivascular spaces in centrum semiovale may be associated with epilepsy after acute ischemic stroke

CNS Neuroscience & Therapeutics, 2022
To investigate the factors influencing enlarged perivascular space (EPVS) characteristics at the onset of acute ischemic stroke (AIS), and whether the PVS characteristics can predict later post‐stroke epilepsy (PSE).
Nian Yu, B. Sinclair, L. Posada, Zhibin Chen, Qing Di, Xing-jian Lin, S. Kolbe, G. Hlauschek, P. Kwan, M. Law   +9 more
semanticscholar   +1 more source

Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

Advanced Science, EarlyView.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie, Ruixi Yang, Xiaotong Wang, Ping Jia, Xueqi Zhang, Yaqi Dai, Xue Bai, Sijia Duan, Yufeng Li, Peng Zheng, Xin Tian, Li Jiang, Chao Wang   +12 more
wiley   +1 more source

Step-by-step pipeline for segmenting enlarged perivascular spaces from 3D T2-weighted MRI [PDF]

, 2023
This dataset contains the matlab code to parcellate the brain, and segment brain tissues, white matter hyperintensities, and perivascular spaces from magnetic resonance imaging (MRI) structural sequences acquired using research ...
Cerebrovascular Research Group, Aribisala, Benjamin, Munoz Maniega, Susana; id_orcid, School of Regeneration and Repair, Edinburgh Neuroscience, Glatz, Andreas, Duarte Coello, Roberto; id_orcid, Euan MacDonald Centre for Motor Neuron Disease Research, Dickie, David Alexander, Edinburgh Imaging, Small Vessel Disease Research, Valdes Hernandez, Maria, Centre for Clinical Brain Sciences, Wardlaw, Joanna, Ballerini, Lucia, Bastin, Mark   +15 more
core   +1 more source

Mega Virchow–Robin

Journal of the Belgian Society of Radiology
Teaching point: Perivascular spaces, also known as Virchow–Robin spaces, are fluid-filled spaces that surround the vessel walls from the subarachnoid space through the brain parenchyma.
Leonor De Almeida Moreira Cameira de Abreu, Sophia Chkili, Denis Tack   +2 more
doaj   +1 more source

A Skull Bone Marrow‐to‐Brain Axis Links Osteoblastic Activity to Myeloid Cell Trafficking, Cerebral Blood Flow, and Cognition in Alzheimer's Progression

Advanced Science, EarlyView.
This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong, Dong Sun, Hao‐Han Guo, Daehoon Lee, Zhipeng Liu, Lin Mei, Wen‐Cheng Xiong   +6 more
wiley   +1 more source

Sleep, Perivascular Spaces, and Cognition in Alzheimer's Disease and Parkinson's Disease [PDF]

, 2022
Cognitive dysfunction, particularly involving memory and executive function, is a core component of neurodegenerative conditions, such as Alzheimer’s disease and Parkinson’s disease.
Tatham, Erica Lee
core  

Ictus isquémico cerebeloso: a propósito de un caso

Galicia Clínica, 2016
Los espacios perivasculares gigantes son dilataciones del espacio subaracnoideo que acompañan a las arterias intracraneales en su trayecto hacia el parénquima cerebral.
Pablo López Mato, Diego Rodríguez Gómez   +1 more
doaj   +1 more source