Results 1 to 10 of about 16,351 (268)

Engineered small extracellular vesicles for targeted delivery of perlecan to stabilise the blood–spinal cord barrier after spinal cord injury [PDF]

Clinical and Translational Medicine
Background Destruction of the blood–spinal cord barrier (BSCB) following spinal cord injury (SCI) can result in various harmful cytokines, neutrophils, and macrophages infiltrating into the injured site, causing secondary damage.
Wei Peng, Wentao Zhang, Wei Cui, Wenjin Chen, Yin Zhuang, Rupeng Chu, Jinghua Tan, Jingbo Xue, Yiguo Yan, Guoyong Yin, Shujun Zhang, Yong Xie   +11 more
doaj   +3 more sources

Diverse and multifunctional roles for perlecan (HSPG2) in repair of the intervertebral disc [PDF]

JOR Spine
Perlecan is a widely distributed, modular, and multifunctional heparan sulfate proteoglycan, which facilitates cellular communication with the extracellular environment to promote tissue development, tissue homeostasis, and optimization of biomechanical ...
James Melrose, Farshid Guilak
doaj   +3 more sources

Perlecan maintains microvessel integrity in vivo and modulates their formation in vitro. [PDF]

PLoS ONE, 2013
Perlecan is a heparan sulfate proteoglycan assembled into the vascular basement membranes (BMs) during vasculogenesis. In the present study we have investigated vessel formation in mice, teratomas and embryoid bodies (EBs) in the absence of perlecan.
Erika Gustafsson, Maylin Almonte-Becerril, Wilhelm Bloch, Mercedes Costell   +3 more
doaj   +17 more sources

Perlecan, a candidate gene for the CAPB locus, regulates prostate cancer cell growth via the Sonic Hedgehog pathway [PDF]

Molecular Cancer, 2006
Background Genetic studies associated the CAPB locus with familial risk of brain and prostate cancers. We have identified HSPG2 (Perlecan) as a candidate gene for CAPB. Previously we have linked Perlecan to Hedgehog signaling in Drosophila. More recently,
Farach-Carson Cindy, Shah Rajal B, Dhir Rajiv, DeGueme Amy M, Kahler Andrea J, Schlicht Michael J, Hernandez Ana, Datta Milton W, Barrett Andrea, Datta Sumana   +9 more
doaj   +2 more sources

Perlecan-Induced Suppression of Smooth Muscle Cell Proliferation Is Mediated Through Increased Activity of the Tumor Suppressor PTEN [PDF]

, 2004
We were interested in the elucidation of the interaction between the heparan sulfate proteoglycan, perlecan, and PTEN in the regulation of vascular smooth muscle cell (SMC) growth.
Costell Rosselló, Mercedes, Garl, Pamela J., Walker, Heather A., Weiser-Evans, C.M., Wenzlau, Janet M., Whitelock, John M.   +5 more
core   +4 more sources

Functionalized Cerium Oxide Nanoparticles Enhance Penetration into Melanoma Spheroids In Vivo through Angiogenesis. [PDF]

Adv Healthc Mater
Melanoma cell spheroid engraftment is optimized in the chicken chorioallantoic membrane overcoming the complexity of other in vivo models. Using this model, greater penetration of cerium oxide nanoparticles (nanoceria) functionalized with heparin in spheroids is observed via enhancement of vascularization than nanoceria alone.
Fu L, Yong JM, Yeh R, Bartlett F, Whitelock JM, Lord MS.   +5 more
europepmc   +2 more sources

Pericellular colocalisation and interactive properties of type VI collagen and perlecan in the intervertebral disc [PDF]

European Cells & Materials, 2016
The aim of this study was to immunolocalise type VI collagen and perlecan and determine their interactive properties in the intervertebral disc (IVD).
AJ Hayes, CC Shu, MS Lord, CB Little, JM Whitelock, J Melrose   +5 more
doaj   +6 more sources

The N-terminal globular domain of the laminin α1 chain binds to α1β1 and α2β1 integrins and to the heparan sulfate-containing domains of perlecan [PDF]

, 1998
The N-terminal domains VI plus V (62 kDa) and V alone (43 kDa) of the laminin α1 chain were obtained as recombinant products and shown to be folded into a native form by electron microscopy and immunological assays.
Ettner, Norbert, Göhring, Walter, Mann, Karlheinz, Sasaki, Takako, Timpl, Rupert   +4 more
core   +3 more sources

Structural changes in cerebral microvasculature induced by ferroptosis contribute to blood-brain barrier disruption in Alzheimer's disease: an autopsy study. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Cerebrovascular lesions are associated with cognitive impairment. However, the impact of AD neuropathological changes (ADNC) on cerebral microvasculature is not completely understood. METHODS Twelve decedents with ADNC and 15 matched controls were selected from the Brain Bank. The changes in the median tunica and basement membrane‐
Cao Y, Huang MY, Mao CH, Wang X, Xu YY, Qian XJ, Ma C, Qiu WY, Zhu YC.   +8 more
europepmc   +2 more sources

The extracellular matrix component perlecan/HSPG2 regulates radioresistance in prostate cancer cells [PDF]

Frontiers in Cell and Developmental Biology
Radiotherapy of prostate cancer (PC) can lead to the acquisition of radioresistance through molecular mechanisms that involve, in part, cell adhesion-mediated signaling.
Ivana Samaržija, Ivana Samaržija, Vasyl Lukiyanchuk, Marija Lončarić, Anja Rac-Justament, Nikolina Stojanović, Ielizaveta Gorodetska, Uğur Kahya, Uğur Kahya, Jonathan D. Humphries, Mahak Fatima, Martin J. Humphries, Ana Fröbe, Anna Dubrovska, Anna Dubrovska, Anna Dubrovska, Anna Dubrovska, Anna Dubrovska, Andreja Ambriović-Ristov   +18 more
doaj   +2 more sources