Results 1 to 10 of about 14,656 (238)

Perlecan maintains microvessel integrity in vivo and modulates their formation in vitro. [PDF]

PLoS ONE, 2013
Perlecan is a heparan sulfate proteoglycan assembled into the vascular basement membranes (BMs) during vasculogenesis. In the present study we have investigated vessel formation in mice, teratomas and embryoid bodies (EBs) in the absence of perlecan.
Erika Gustafsson, Maylin Almonte-Becerril, Wilhelm Bloch, Mercedes Costell   +3 more
doaj   +11 more sources

Perlecan, a candidate gene for the CAPB locus, regulates prostate cancer cell growth via the Sonic Hedgehog pathway [PDF]

Molecular Cancer, 2006
Background Genetic studies associated the CAPB locus with familial risk of brain and prostate cancers. We have identified HSPG2 (Perlecan) as a candidate gene for CAPB. Previously we have linked Perlecan to Hedgehog signaling in Drosophila. More recently,
Farach-Carson Cindy, Shah Rajal B, Dhir Rajiv, DeGueme Amy M, Kahler Andrea J, Schlicht Michael J, Hernandez Ana, Datta Milton W, Barrett Andrea, Datta Sumana   +9 more
doaj   +2 more sources

Perlecan-Induced Suppression of Smooth Muscle Cell Proliferation Is Mediated Through Increased Activity of the Tumor Suppressor PTEN [PDF]

, 2004
We were interested in the elucidation of the interaction between the heparan sulfate proteoglycan, perlecan, and PTEN in the regulation of vascular smooth muscle cell (SMC) growth.
Costell Rosselló, Mercedes, Garl, Pamela J., Walker, Heather A., Weiser-Evans, C.M., Wenzlau, Janet M., Whitelock, John M.   +5 more
core   +4 more sources

Pericellular colocalisation and interactive properties of type VI collagen and perlecan in the intervertebral disc [PDF]

European Cells & Materials, 2016
The aim of this study was to immunolocalise type VI collagen and perlecan and determine their interactive properties in the intervertebral disc (IVD).
AJ Hayes, CC Shu, MS Lord, CB Little, JM Whitelock, J Melrose   +5 more
doaj   +6 more sources

Association Between Endothelial Alterations, Cardiac Function, and Outcomes From Health to Heart Failure: Insight From the STANISLAS, MEDIA‐DHF, and BIOSTAT‐CHF Cohorts [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Heart failure with preserved ejection fraction (HFpEF) is a multifaceted syndrome, likely stemming from comorbidity‐induced inflammation resulting in endothelial dysfunction.
Jeremy Lagrange, Mohammad Jahangiri, Guillaume Baudry, Nathalie Mercier, Luca Monzo, Zohra Lamiral, Kévin Duarte, Jozine M ter Maaten, Faiez Zannad, Adriaan A. Voors, Nicolas Girerd   +10 more
doaj   +2 more sources

Engineered small extracellular vesicles for targeted delivery of perlecan to stabilise the blood–spinal cord barrier after spinal cord injury [PDF]

Clinical and Translational Medicine
Background Destruction of the blood–spinal cord barrier (BSCB) following spinal cord injury (SCI) can result in various harmful cytokines, neutrophils, and macrophages infiltrating into the injured site, causing secondary damage.
Wei Peng, Wentao Zhang, Wei Cui, Wenjin Chen, Yin Zhuang, Rupeng Chu, Jinghua Tan, Jingbo Xue, Yiguo Yan, Guoyong Yin, Shujun Zhang, Yong Xie   +11 more
doaj   +2 more sources

Diverse and multifunctional roles for perlecan (HSPG2) in repair of the intervertebral disc [PDF]

JOR Spine
Perlecan is a widely distributed, modular, and multifunctional heparan sulfate proteoglycan, which facilitates cellular communication with the extracellular environment to promote tissue development, tissue homeostasis, and optimization of biomechanical ...
James Melrose, Farshid Guilak
doaj   +2 more sources

The glycosylation-dependent interaction of perlecan core protein with LDL: implications for atherosclerosis[S] [PDF]

Journal of Lipid Research, 2015
Perlecan is a major heparan sulfate (HS) proteoglycan in the arterial wall. Previous studies have linked it to atherosclerosis. Perlecan contains a core protein and three HS side chains. Its core protein has five domains (DI–DV) with disparate structures
Yu-Xin Xu, David Ashline, Li Liu, Carlos Tassa, Stanley Y. Shaw, Katya Ravid, Matthew D. Layne, Vernon Reinhold, Phillips W. Robbins   +8 more
doaj   +2 more sources

The extracellular matrix component perlecan/HSPG2 regulates radioresistance in prostate cancer cells [PDF]

Frontiers in Cell and Developmental Biology
Radiotherapy of prostate cancer (PC) can lead to the acquisition of radioresistance through molecular mechanisms that involve, in part, cell adhesion-mediated signaling.
Ivana Samaržija, Ivana Samaržija, Vasyl Lukiyanchuk, Marija Lončarić, Anja Rac-Justament, Nikolina Stojanović, Ielizaveta Gorodetska, Uğur Kahya, Uğur Kahya, Jonathan D. Humphries, Mahak Fatima, Martin J. Humphries, Ana Fröbe, Anna Dubrovska, Anna Dubrovska, Anna Dubrovska, Anna Dubrovska, Anna Dubrovska, Andreja Ambriović-Ristov   +18 more
doaj   +2 more sources

Expanding genetic and clinical aspects of Schwartz-Jampel syndrome: A report of two cases with literature review [PDF]

Molecular Genetics and Metabolism Reports
Schwartz-Jampel syndrome (SJS) is a rare autosomal recessive disorder characterized by muscle stiffness (myotonia) and chondrodysplasia. This disease is caused by biallelic loss of function mutations in the HSPG2 gene, which encodes the core protein of ...
Iman Elahi Vahed, Sahand Tehrani Fateh, Melika Kamali, Farzad Hashemi-Gorji, Zahra Esmaeilzadeh, Hossein Sadeghi, Mohammad Miryounesi, Mohammad-Reza Ghasemi   +7 more
doaj   +2 more sources