Results 1 to 10 of about 7,639 (196)

Intervertebral Disc Proteoglycans: Multifunctional Tissue Stabilizing and Instructional Cell Regulatory Proteins That Control Tissue Homeostasis [PDF]

JOR Spine
The intervertebral disc (IVD) is a tough fibrocartilaginous viscoelastic cushion interposed between spinal vertebrae. It has a composite structure whose material properties are due to the interplay between fibrillar collagens which, provide high tensile ...
James Melrose
doaj   +3 more sources

Perlecan, CollagenXVIII, and Agrin Expression in Normo-, Hypo-, and Aganglionic Segments in Hirschsprung's Disease. [PDF]

Neurogastroenterol Motil
The secretory heparan sulphate proteoglycans perlecan, agrin, collagen18A1 are expressed in the periganglionic sheath of enteric ganglia in resectates of Hirschsprung's disease patients and non‐Hirschsprung controls. ABSTRACT Background Secretory heparan sulphate proteoglycans (HSPGs) interact with various morphogens, growth factors, and signaling ...
van den Beld N, Fischer M, Scharr M, Scherer S, Beschorner R, Hirt B, Neckel PH.   +6 more
europepmc   +4 more sources

Perlecan: a review of its role in neurologic and musculoskeletal disease [PDF]

Frontiers in Physiology, 2023
Perlecan is a 500 kDa proteoglycan residing in the extracellular matrix of endothelial basement membranes with five distinct protein domains and three heparan sulfate chains.
Tessa R. Lavorgna, Timothy E. Gressett, Timothy E. Gressett, Wesley H. Chastain, Wesley H. Chastain, Gregory J. Bix, Gregory J. Bix, Gregory J. Bix   +7 more
doaj   +2 more sources

Cancer Metastasis: The Role of the Extracellular Matrix and the Heparan Sulfate Proteoglycan Perlecan [PDF]

Frontiers in Oncology, 2020
Cancer metastasis is the dissemination of tumor cells to new sites, resulting in the formation of secondary tumors. This process is complex and is spatially and temporally regulated by intrinsic and extrinsic factors.
Zehra Elgundi, Michael Papanicolaou, Michael Papanicolaou, Gretel Major, Thomas R. Cox, Thomas R. Cox, James Melrose, James Melrose, John M. Whitelock, Brooke L. Farrugia, Brooke L. Farrugia   +10 more
doaj   +2 more sources

Perlecan (HSPG2) promotes structural, contractile, and metabolic development of human cardiomyocytes [PDF]

Cell Reports
Summary: Perlecan (HSPG2), a heparan sulfate proteoglycan similar to agrin, is key for extracellular matrix (ECM) maturation and stabilization. Although crucial for cardiac development, its role remains elusive. We show that perlecan expression increases
Benjamin B. Johnson, Marie-Victoire Cosson, Lorenza I. Tsansizi, Terri L. Holmes, Tegan Gilmore, Katherine Hampton, Ok-Ryul Song, Nguyen T.N. Vo, Aishah Nasir, Alzbeta Chabronova, Chris Denning, Mandy J. Peffers, Catherine L.R. Merry, John Whitelock, Linda Troeberg, Stuart A. Rushworth, Andreia S. Bernardo, James G.W. Smith   +17 more
doaj   +2 more sources

Engineered small extracellular vesicles for targeted delivery of perlecan to stabilise the blood–spinal cord barrier after spinal cord injury [PDF]

Clinical and Translational Medicine
Background Destruction of the blood–spinal cord barrier (BSCB) following spinal cord injury (SCI) can result in various harmful cytokines, neutrophils, and macrophages infiltrating into the injured site, causing secondary damage.
Wei Peng, Wentao Zhang, Wei Cui, Wenjin Chen, Yin Zhuang, Rupeng Chu, Jinghua Tan, Jingbo Xue, Yiguo Yan, Guoyong Yin, Shujun Zhang, Yong Xie   +11 more
doaj   +2 more sources

Association Between Endothelial Alterations, Cardiac Function, and Outcomes From Health to Heart Failure: Insight From the STANISLAS, MEDIA‐DHF, and BIOSTAT‐CHF Cohorts [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Heart failure with preserved ejection fraction (HFpEF) is a multifaceted syndrome, likely stemming from comorbidity‐induced inflammation resulting in endothelial dysfunction.
Jeremy Lagrange, Mohammad Jahangiri, Guillaume Baudry, Nathalie Mercier, Luca Monzo, Zohra Lamiral, Kévin Duarte, Jozine M ter Maaten, Faiez Zannad, Adriaan A. Voors, Nicolas Girerd   +10 more
doaj   +2 more sources

Matrilysin/MMP-7 Cleavage of Perlecan/HSPG2 Complexed with Semaphorin 3A Supports FAK-Mediated Stromal Invasion by Prostate Cancer Cells [PDF]

Scientific Reports, 2018
Interrupting the interplay between cancer cells and extracellular matrix (ECM) is a strategy to halt tumor progression and stromal invasion. Perlecan/heparan sulfate proteoglycan 2 (HSPG2) is an extracellular proteoglycan that orchestrates tumor ...
Brian J. Grindel, Jerahme R. Martinez, Tristen V. Tellman, Daniel A. Harrington, Hamim Zafar, Luay Nakhleh, Leland W. Chung, Mary C. Farach-Carson   +7 more
doaj   +2 more sources

Diverse and multifunctional roles for perlecan (HSPG2) in repair of the intervertebral disc [PDF]

JOR Spine
Perlecan is a widely distributed, modular, and multifunctional heparan sulfate proteoglycan, which facilitates cellular communication with the extracellular environment to promote tissue development, tissue homeostasis, and optimization of biomechanical ...
James Melrose, Farshid Guilak
doaj   +2 more sources

Modulation of Perlecan Protein towards Chondrocyte Secretion Factors at the Articular Cartilage in Hyperglycemic Animal Model [PDF]

Journal of Pure and Applied Chemistry Research, 2019
High carbohydrate influences the cartilage microcellular environment and chondrocytes. Perlecan (HSPG2) conducts an essential role as chondrocytes mechano-transducer and chondrocytes secretion factors. This research aims to fulfill the research gap about
Ibrahim Njoto, Fatchiyah Fatchiyah, Kusworini Handono, Abdurrachman Abdurrachman, Djoko W. Soeatmadji, Handono Kalim   +5 more
doaj   +3 more sources