Results 91 to 100 of about 16,351 (268)
BMEMat, EarlyView.Efficient drug delivery to the posterior segment of the eye has long been a challenging issue due to the complex ocular barriers. The review focuses on the promise held by nanoplatforms for barrier penetration and the key mechanisms involved, also highlighting their advantages in achieving efficient drug delivery and superior treatment of PSEDs ...
Yifan Shen +7 more
wiley +1 more source
Perlecan regulates pericyte dynamics in the maintenance and repair of the blood–brain barrier
Journal of Cell Biology, 2019 Pericytes play important roles in the repair of the blood–brain barrier (BBB). Nakamura et al. show that an ECM protein, perlecan, maintains BBB integrity and regulates pericyte recruitment after ischemic stroke through the cooperative function of PDGFRβ
Kuniyuki Nakamura +11 more
semanticscholar +1 more source
Intelligent Manufacturing for Osteoarthritis Organoids
Cell Proliferation, EarlyView.Overall schematic of intelligent manufacturing in osteoarthritis organoids. Broad overview of the article's structure, outlining the progression from fundamental joint anatomy and OA pathogenesis to organoid construction and, ultimately, to intelligent manufacturing and future prospects.
Xukun Lyu, Jian Wang, Jiacan Su
wiley +1 more source
Endorepellin remodels the endothelial transcriptome toward a pro-autophagic and pro-mitophagic gene signature. [PDF]
, 2018 Regulation of autophagy by proteolytically cleaved fragments of heparan sulfate proteoglycans is a novel and current research focus in tumor biology. Endorepellin is the C-terminal angiostatic fragment of the heparan sulfate proteoglycan perlecan and ...
Andreuzzi, Eva +5 more
core +1 more source
The role of perlecan and endorepellin in the control of tumor angiogenesis and endothelial cell autophagy. [PDF]
, 2015 During tumor growth and angiogenesis there is a dynamic remodeling of tissue architecture often accompanied by the release of extracellular matrix constituents full of biological activity.
Douglass, Stephen +2 more
core +2 more sources
Molecular Microbiology, EarlyView.A novel approach using the Pseudomonas syringae ice nucleation protein (INP) system to present Borrelia burgdorferi lipoproteins on the surface of Escherichia coli reveals conservation of complement inhibitory functions among uncharacterized OspE/F‐like leader peptide (Elp) proteins.
Nathan Hill +10 more
wiley +1 more source
Molecular & Cellular Proteomics, 2020 Perlecan deficiency affects the material properties of developing cartilage. Imaging and proteomic analyses of a murine model of SJS revealed pericellular matrix formation, bulk matrix content and glycosaminoglycan deposition at the articular surface ...
Alexander R. Ocken +3 more
semanticscholar +1 more source
An environmentally-friendly perlecan protein expression
Journal of Physics: Conference Series, 2020 Abstract The risk of high sugar level exposure can affect almost all parts of the body, organ systems, tissues, to the cellular level. The exposure to high sugar level caused disturbances in the joints in the form of changes in the microcellular environment. It will cause negative impact to microcellular component of articular cartilage,
Abdurrachman Abdurrachman +7 more
openaire +2 more sources
The CS sulphation motifs 4C3, 7D4, 3B3[-]; and perlecan identify stem cell populations and niches, activated progenitor cells and transitional tissue development in the fetal human elbow [PDF]
, 2016 We compared the immunohistochemical distribution of (i) the novel chondroitin sulphate (CS) sulphation motifs 7D4, 4C3 and 3B3[-], (ii) native heparan sulphate (HS) and Δ-HS ‘stubs’ generated by heparitinase III digestion and (iii) the HS-proteoglycan ...
Caterson, Bruce +5 more
core +1 more source
Exploring neuronal mechanisms of osteosarcopenia in older adults
The Journal of Physiology, EarlyView.Abstract figure legend The mechanosensitive osteocytic network within the bone matrix acts as a receptor and plays a crucial role in the functional adaptation of bone to mechanical loading. Through mechanotransduction, osteocytes convert mechanical impulses into electrical signals, which are transmitted via afferent nerves to sympathetic preganglionic ...
Ilhan Karacan, Kemal Sıtkı Türker
wiley +1 more source