Results 101 to 110 of about 14,656 (238)
Aging Cell, Volume 24, Issue 9, September 2025.The maintenance of aging mesenchymal stem cells (MSCs) on extracellular matrix synthesized by human amniotic fluid‐derived pluripotent stem cells (ECM Plus), a young microenvironment, remarkably restored their quantity and quality along with up‐regulating HLA‐DR and CD74.
Aaron O. Gonzalez +10 more
wiley +1 more source
A biomechanical role for perlecan in the pericellular matrix of articular cartilage [PDF]
Matrix Biology, 2012 Chondrocytes are surrounded by a narrow pericellular matrix (PCM) that is biochemically, structurally, and biomechanically distinct from the bulk extracellular matrix (ECM) of articular cartilage. While the PCM is often defined by the presence of type VI collagen, other macromolecules such as perlecan, a heparan sulfate (HS) proteoglycan, are also ...
Farshid Guilak +2 more
openaire +3 more sources
Role of collagens and perlecan in microvascular stability: exploring the mechanism of capillary vessel damage by snake venom metalloproteinases. [PDF]
PLoS ONE, 2011 Hemorrhage is a clinically important manifestation of viperid snakebite envenomings, and is induced by snake venom metalloproteinases (SVMPs). Hemorrhagic and non-hemorrhagic SVMPs hydrolyze some basement membrane (BM) and associated extracellular matrix
Teresa Escalante +6 more
doaj +1 more source
Variations in the Peritrophic Matrix Composition of Heparan Sulphate from the Tsetse Fly, Glossina morsitans morsitans [PDF]
, 2018 Tsetse flies are the principal insect vectors of African trypanosomes—sleeping sickness in humans and Nagana in cattle. One of the tsetse fly species, Glossina morsitans morsitans, is host to the parasite, Trypanosoma brucei, a major cause of African ...
Acosta-Serrano, A +8 more
core +5 more sources
Physiologia Plantarum, Volume 177, Issue 5, September/October 2025.ABSTRACT Collagen‐derived protein hydrolysates (CDPH) are widely used as plant biostimulants primarily due to their content of bioactive oligopeptides. When applied to hydroponically grown Solanum lycopersicum plants, CDPH significantly promoted root development, particularly by increasing the number and length of lateral roots.
Stefano Ambrosini +5 more
wiley +1 more source
Perlecan Maintains the Integrity of Cartilage and Some Basement Membranes [PDF]
The Journal of Cell Biology, 1999 Perlecan is a heparan sulfate proteoglycan that is expressed in all basement membranes (BMs), in cartilage, and several other mesenchymal tissues during development. Perlecan binds growth factors and interacts with various extracellular matrix proteins and cell adhesion molecules. Homozygous mice with a null mutation in the perlecan gene exhibit normal
Matthias Mörgelin +8 more
openaire +3 more sources
Investigating the Expression and Function of CCN2 in Articular Cartilage
, 2009 The pericellular matrix (PCM) is a distinct zone of matrix that surrounds individual chondrocytes throughout articular cartilage. Although not much is known about its function, our group has shown that it has a role in mechanotransduction by controlling ...
McLean, Celia, McLean, Celia
core +1 more source
Perlecan and synaptophysin changes in denervated skeletal muscle.
Neural regeneration research, 2012 The present study observed sciatic nerve and gastrocnemius muscle changes in denervated rats using morphology methods, and assessed expression of perlecan, an extracellular matrix component, which is located at the skeletal muscle cell surface as acetylcholine esterase, as well as synaptophysin, a synaptic marker.
Huiming Wang +5 more
openaire +3 more sources
Cytoneme-mediated signaling essential for tumorigenesis. [PDF]
, 2019 Communication between neoplastic cells and cells of their microenvironment is critical to cancer progression. To investigate the role of cytoneme-mediated signaling as a mechanism for distributing growth factor signaling proteins between tumor and tumor ...
Fereres, Sol +3 more
core +1 more source
Clinical and Translational Allergy, Volume 15, Issue 8, August 2025.ABSTRACT Background Asthma is characterized by airway obstruction driven by chronic inflammation, leading to extracellular matrix (ECM) remodeling. This involves ECM alterations, including increased collagen deposition and elastolysis, resulting in airway wall thickening and irreversible airflow limitation. Despite ECM remodeling's known role in asthma,
Matej Andelic +4 more
wiley +1 more source