Results 101 to 110 of about 16,351 (268)
Basement membrane proteoglycans: modulators Par Excellence of cancer growth and angiogenesis. [PDF]
, 2009 Proteoglycans located in basement membranes, the nanostructures underling epithelial and endothelial layers, are unique in several respects. They are usually large, elongated molecules with a collage of domains that share structural and functional ...
Iozzo, Renato V +2 more
core +2 more sources
Membrane trafficking of synaptic adhesion molecules
The Journal of Physiology, EarlyView.Abstract figure legend Synaptic cellular adhesion molecules are surface transmembrane receptors that have been shown to internalize via endocytosis, and possibly also recycle, in a process that has been linked to the function and the turnover of the synaptic contact site.
Cristian A. Bogaciu, Silvio O. Rizzoli
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Schematic illustration of the bidirectional causative link between cerebral amyloid‐beta (Aβ) angiopathy and cardiovascular disease in Alzheimer's disease (AD). Common cardiovascular risk factors like microvascular thrombosis, diabetes, atrial fibrillation, hypertension and atherosclerosis lead to cerebral hypoperfusion and ...
Samuel Parker +2 more
wiley +1 more source
Role of collagens and perlecan in microvascular stability: exploring the mechanism of capillary vessel damage by snake venom metalloproteinases. [PDF]
PLoS ONE, 2011 Hemorrhage is a clinically important manifestation of viperid snakebite envenomings, and is induced by snake venom metalloproteinases (SVMPs). Hemorrhagic and non-hemorrhagic SVMPs hydrolyze some basement membrane (BM) and associated extracellular matrix
Teresa Escalante +6 more
doaj +1 more source
UDP‐glucose dehydrogenase variants cause dystroglycanopathy
Annals of Clinical and Translational Neurology, Volume 12, Issue 6, Page 1302-1308, June 2025.Abstract UDP‐glucose dehydrogenase (UGDH) variants have been associated with hypotonia, developmental delay, and epilepsy. We report the first pathologic evidence of dystroglycanopathy in siblings with UGDH variants. Both presented around 6 months with developmental delay and elevated creatinine kinase.
Anna M. Reelfs +8 more
wiley +1 more source
Journal of mammary gland biology and neoplasia, 2020 Localised breast cancer can be cured by surgery and adjuvant treatments, but mortality remains high as some tumours metastasize early. Perlecan is a basement membrane (BM) protein involved in tumour development and progression.
M. Jansson +6 more
semanticscholar +1 more source
Frontiers in Integrative Neuroscience, 2017 Unspecialized, self-renewing stem cells have extraordinary application to regenerative medicine due to their multilineage differentiation potential.
Chieh Yu +2 more
doaj +1 more source
Advanced Science, Volume 12, Issue 23, June 20, 2025.CCN1 modulates the tumor microenvironment in pancreatic cancer by promoting collagen‐dependent chemokine production, thereby facilitating immune evasion. Deletion of CCN1 not only suppresses tumor growth but also enhances immune cell infiltration and increases tumor sensitivity to both chemotherapy and immunotherapy.
Hongjie Fan +9 more
wiley +1 more source
A central function for perlecan in skeletal muscle and cardiovascular development [PDF]
The Journal of Cell Biology, 2008 Perlecan's developmental functions are difficult to dissect in placental animals because perlecan disruption is embryonic lethal. In contrast to mammals, cardiovascular function is not essential for early zebrafish development because the embryos obtain adequate oxygen by diffusion.
Zoeller, Jason J. +4 more
openaire +3 more sources
Mast cells produce a unique chondroitin sulfate epitope [PDF]
, 2016 The granules of mast cells contain a myriad of mediators that are stored and protected by the sulfated glycosaminoglycan (GAG) chains that decorate proteoglycans.
Caterson, Bruce +4 more
core +1 more source