Results 111 to 120 of about 16,351 (268)

First Steps toward the Design of Peptides that Influence the Intracellular Palmitoylation Machinery

ChemBioChem, Volume 26, Issue 10, May 27, 2025.
Herein, DC peptides consisting of the cell‐penetrating peptide sC18* and a Asp–His–His–Cys (DHHC) motif derived from human ZDHHC palmitoyltransferase are highlighted. DC peptides demonstrate high cellular internalization into various cellular models, exert cytotoxic effects against cancerous cells, and alter the function and localization of known ...
Katharina Stillger, Eric Platz‐Baudin, Florian Friedland, Melina Ruppel, Coco‐Louisa Sticker, Anne Bodenhausen, Erik Noetzel, Ines Neundorf   +7 more
wiley   +1 more source

The perlecan LDL-binding receptor needs sugar: Implication of perlecan core protein interaction with LDL for atherosclerosis [PDF]

Receptors & Clinical Investigation, 2015
Cardiovascular disease (CVD) is the deadliest disease in the US and finding cures for CVD has been a pressing and challenging problem in biomedical science. Atherosclerosis is a pathological condition caused by an elevated plasma LDL cholesterol level and its deposition in the arterial wall.
openaire   +1 more source

Control of cell division in the adult brain by heparan sulfates in fractones and vascular basement membranes [PDF]

, 2010
Regulation of cell division in adult tissues and organs requires the coordination of growth factors at the surface of potentially-dividing cells in specific anatomic loci named germinal niches.
Frederic Mercier, Vanessa Douet
core   +1 more source

A screen for round egg mutants in Drosophila identifies tricornered, furry, and misshapen as regulators of egg chamber elongation. [PDF]

, 2012
The elongation of tissues and organs during embryonic development results from the coordinate polarization of cell behaviors with respect to the elongation axis.
Bilder, David, Gerlach, Gary, Hill, Joseph, Horne-Badovinac, Sally, Menegas, William   +4 more
core   +2 more sources

The Pathobiology of Cerebrovascular Lesions in CADASIL Small Vessel Disease

Basic &Clinical Pharmacology &Toxicology, Volume 136, Issue 5, May 2025.
ABSTRACT Cerebral small vessel disease (cSVD) is a significant global health issue, accounting for approximately 25% of ischemic strokes and 20% of all dementia cases. CADASIL, the most common monogenic form of cSVD, is caused by stereotyped mutations in the NOTCH3 receptor that alter the number of cysteine residues in its extracellular domain ...
Anne Joutel
wiley   +1 more source

A biomechanical role for perlecan in the pericellular matrix of articular cartilage [PDF]

Matrix Biology, 2012
Chondrocytes are surrounded by a narrow pericellular matrix (PCM) that is biochemically, structurally, and biomechanically distinct from the bulk extracellular matrix (ECM) of articular cartilage. While the PCM is often defined by the presence of type VI collagen, other macromolecules such as perlecan, a heparan sulfate (HS) proteoglycan, are also ...
Farshid Guilak, Louis E. DeFrate, Rebecca E. Wilusz   +2 more
openaire   +3 more sources

Differential expression of proteoglycans in tissue remodeling and lymphangiogenesis after experimental renal transplantation in rats. [PDF]

PLoS ONE, 2010
BACKGROUND: Chronic transplant dysfunction explains the majority of late renal allograft loss and is accompanied by extensive tissue remodeling leading to transplant vasculopathy, glomerulosclerosis and interstitial fibrosis. Matrix proteoglycans mediate
Heleen Rienstra, Kirankumar Katta, Johanna W A M Celie, Harry van Goor, Gerjan Navis, Jacob van den Born, Jan-Luuk Hillebrands   +6 more
doaj   +1 more source

Alternative Splicing of FBLN2 Generates a Prometastatic Extracellular Matrix in Gastrointestinal Cancers by Determining N‐Glycosylation of Fibulin 2

Genes to Cells, Volume 30, Issue 3, May 2025.
Fibulin 2 (FBLN2) is an extracellular matrix (ECM) glycoprotein that exists as two alternative splice variants—v1 and v2—with only v1 including the amino acid sequence encoded by exon 9. Whereas the exclusion of FBLN2 exon 9 is one of the most recurrent splicing events across multiple types of cancer, its functional relevance in cancer has remained ...
Ryo Funayama, Yujue Wang, Masaki Hosogane, Wei‐Chen Kao, Shingo Toyama, Masahiro Ohira, Masaki Matsumoto, Takashi Aizawa, Minoru Kobayashi, Hideaki Karasawa, Shinobu Ohnuma, Keiichi I. Nakayama, Michiaki Unno, Keiko Nakayama   +13 more
wiley   +1 more source

Perlecan Maintains the Integrity of Cartilage and Some Basement Membranes [PDF]

The Journal of Cell Biology, 1999
Perlecan is a heparan sulfate proteoglycan that is expressed in all basement membranes (BMs), in cartilage, and several other mesenchymal tissues during development. Perlecan binds growth factors and interacts with various extracellular matrix proteins and cell adhesion molecules. Homozygous mice with a null mutation in the perlecan gene exhibit normal
Matthias Mörgelin, Wilhelm Bloch, Rupert Timpl, Klaus Addicks, Attila Aszódi, Reinhard Fässler, Erika Gustafsson, Mercedes Costell, Ernst B. Hunziker   +8 more
openaire   +3 more sources

Searching urinary tumor-associated proteins for bladder transitional cell carcinoma in southwestern Taiwan using gel-based proteomics

Urological Science, 2016
Background and purpose: We try to search for specific serum or urinary biomarkers for the early detection, follow-up, and prediction of tumor recurrence, progression, and clinical outcome is a difficult task in individuals with bladder cancer.
Chia-Cheng Su, Kun-Hung Sheng, Shih-Ying Chen, Yeou-Guang Tsay, Ting-Feng Wu   +4 more
doaj   +1 more source