Results 121 to 130 of about 16,351 (268)
Deficiency in Perlecan/HSPG2 During Bone Development Enhances Osteogenesis and Decreases Quality of Adult Bone in Mice [PDF]
Perlecan/HSPG2 (Pln) is a large heparan sulfate proteoglycan abundant in the extracellular matrix of cartilage and the lacunocanalicular space of adult bones.
Farach-Carson, Mary C.+7 more
core +1 more source
ABSTRACT Background A healthy skin barrier is essential to protect against the entry of harmful substances or the loss of internal fluids, especially water and electrolytes. Various aggressions are known to weaken the skin barrier. Aims To evaluate single or multiple applications of a serum formula designed to mitigate skin barrier dysfunction and ...
Caroline Pichon+4 more
wiley +1 more source
Review of Alterations in Perlecan-Associated Vascular Risk Factors in Dementia
Perlecan is a heparan sulfate proteoglycan protein in the extracellular matrix that structurally and biochemically supports the cerebrovasculature by dynamically responding to changes in cerebral blood flow.
A. Trout, I. Rutkai, I. Biose, G. Bix
semanticscholar +1 more source
Background Heart failure with preserved ejection fraction (HFpEF) is a multifaceted syndrome, likely stemming from comorbidity‐induced inflammation resulting in endothelial dysfunction.
Jeremy Lagrange+10 more
doaj +1 more source
The ability of human induced pluripotent stem cells (hiPSCs) to model developmental processes makes them a promising source for engineering testicular tissues to study in vitro maturation and sperm production. This work describes the first hiPSC‐derived testicular model and shows that it captures functional aspects of prepubertal testicular tissues ...
Meghan A Robinson+15 more
wiley +1 more source
The basement membrane (BM) provides mechanical shaping of tissues during morphogenesis. The Drosophila BM proteoglycan Perlecan is vital for this process in the wing imaginal disc.
Raphaël Bonche+5 more
semanticscholar +1 more source
Mimicking the Dystrophic Cardiac Extracellular Environment through DystroGel
This research introduces DystroGel, a cutting‐edge biocompatible pathological hydrogel derived from decellularized dystrophic porcine heart tissue, suitable for tissue modeling applications. Rheological and proteomic analyses reveal structural and protein composition modifications, underscoring its unique properties.
Maila Chirivì+19 more
wiley +1 more source
The main purpose of this in situ hybridization study was to investigate mRNA expression of three bone/cartilage matrix components (perlecan, DMP1, and MEPE) in developing primary (tibial) and secondary (condylar) cartilage.
K. Fujikawa+5 more
doaj +1 more source
Allosteric modulation of beta1 integrin function induces lung repair in animal model of emphysema. [PDF]
Emphysema is a progressive lung disease characterised by loss of lung parenchyma with associated functional changes including decreased tissue elastance. Here we report beta1 integrin is a novel target for tissue repair and regeneration in emphysema.
Chris J. Armit+6 more
core +1 more source
A novel approach for the characterisation of proteoglycans and biosynthetic enzymes in a snail model [PDF]
Proteoglycans encompass a heterogeneous group of glycoconjugates where proteins are substituted with linear, highly negatively charged glycosaminoglycan chains.
Almeida, Igor Correia de+10 more
core +2 more sources