Glycosaminoglycans and Proteoglycans
Pharmaceuticals, 2018 In this editorial to MDPI Pharmaceuticals special issue “Glycosaminoglycans and Proteoglycans” we describe in outline the common structural features of glycosaminoglycans and the characteristics of proteoglycans, including the intracellular proteoglycan,
Vitor H. Pomin, Barbara Mulloy
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Extracellular Matrix Molecules Facilitating Vascular Biointegration
Journal of Functional Biomaterials, 2012 All vascular implants, including stents, heart valves and graft materials exhibit suboptimal biocompatibility that significantly reduces their clinical efficacy.
Martin K.C. Ng +3 more
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Chimeric protein repair of laminin polymerization ameliorates muscular dystrophy phenotype [PDF]
, 2017 Mutations in laminin α2-subunit (Lmα2, encoded by LAMA2) are linked to approximately 30% of congenital muscular dystrophy cases. Mice with a homozygous mutation in Lama2 (dy2J mice) express a nonpolymerizing form of laminin-211 (Lm211) and are a model ...
Crosson, Stephanie C. +5 more
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Basement membrane proteoglycans: modulators Par Excellence of cancer growth and angiogenesis. [PDF]
, 2009 Proteoglycans located in basement membranes, the nanostructures underling epithelial and endothelial layers, are unique in several respects. They are usually large, elongated molecules with a collage of domains that share structural and functional ...
Iozzo, Renato V +2 more
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Endothelial cells interact with the core protein of basement membrane perlecan through beta 1 and beta 3 integrins: an adhesion modulated by glycosaminoglycan. [PDF]
, 1992 K Hayashi +2 more
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Perlecan Domain V Therapy for Stroke: A Beacon of Hope? [PDF]
ACS Chemical Neuroscience, 2012 The sad reality is that in the year 2012, people are still dying or suffering from the extreme morbidity of ischemic stroke. This tragedy is only compounded by the graveyard full of once promising new therapies. While it is indeed true that the overall mortality from stroke has declined in the United States, perhaps due to increased awareness of stroke
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Az érfal trombogenitása és annak szabályozása = Vessel wall thrombogenicity and its regulation [PDF]
, 2008 Fiziológiás hemosztázis ill. artériás trombózis keletkezésekor a trombociták a gyorsan áramló vérből von Willebrand faktoron keresztül tapadnak ki az érfalban lévő kollagénhez. Az érfal mátrix komponenseit vizsgálva megállapítottuk, hogy a media rétegből
Gombás, Judit +2 more
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The Relationship between Perlecan and Dystroglycan and its Implication in the Formation of the Neuromuscular Junction [PDF]
, 1998 H. Benjamin Peng +5 more
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Perlecan: An Islet Basement Membrane Protein with Protective Anti-Inflammatory Characteristics
BioengineeringThroughout the isolation process, human islets are subjected to destruction of the islet basement membrane (BM) and reduced oxygen supply. Reconstruction of the BM represents an option to improve islet function and survival post-transplant and may ...
Daniel Brandhorst +3 more
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Structural and Functional Characterization of the Human Perlecan Gene Promoter [PDF]
, 1997 Renato V. Iozzo +6 more
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