Perlecan and synaptophysin changes in denervated skeletal muscle.
Neural regeneration research, 2012 The present study observed sciatic nerve and gastrocnemius muscle changes in denervated rats using morphology methods, and assessed expression of perlecan, an extracellular matrix component, which is located at the skeletal muscle cell surface as acetylcholine esterase, as well as synaptophysin, a synaptic marker.
Huiming Wang +5 more
openaire +3 more sources
Sulodexide decreases albuminuria and regulates matrix protein accumulation in C57BL/6 mice with streptozotocin-induced type I diabetic nephropathy [PDF]
, 2013 OBJECTIVE: Sulodexide is a mixture of glycosaminoglycans that may reduce proteinuria in diabetic nephropathy (DN), but its mechanism of action and effect on renal histology is not known. We investigated the effect of sulodexide on disease manifestations
Chan, DTM +4 more
core +1 more source
Discovery of HSPG2 (Perlecan) as a Therapeutic Target in Triple Negative Breast Cancer
Scientific Reports, 2019 In recent years, there have been significant advances in the treatment of breast cancer resulting in remarkably high survival rates. However, treatment options for metastatic triple negative breast cancer (TNBC) are quite limited due to a lack of ...
Stephen Kalscheuer +7 more
semanticscholar +1 more source
The developmental roles of the extracellular matrix: Beyond structure to regulation [PDF]
, 2010 Cells in multicellular organisms are surrounded by a complex three-dimensional macromolecular extracellular matrix (ECM). This matrix, traditionally thought to serve a structural function providing support and strength to cells within tissues, is ...
Chan, D +3 more
core +1 more source
Pathogenesis of abdominal aortic aneurysms: Possible role of differential production of proteoglycans by smooth muscle cells [PDF]
, 1998 Purpose: In vivo and in vitro observations strongly suggest that marked differences exist in the phenotype, growth, and matrix-producing capabilities of distinct smooth muscle cell subpopulations.
Ghosh, Peter +3 more
core +1 more source
Perlecan-targeted nanoparticles for drug delivery to triple-negative breast cancer
Future Drug Discovery, 2019 Aim: We previously developed two antibodies that bind to a cell surface protein, perlecan, overexpressed in triple-negative breast cancer (TNBC). The goal of this study was to investigate these antibodies as targeting ligands for nanoparticle-mediated ...
Vidhi Khanna +4 more
semanticscholar +1 more source
Dynamic regulation of basement membrane protein levels promotes egg chamber elongation in Drosophila [PDF]
, 2015 Basement membranes (BMs) are sheet-like extracellular matrices that provide essential support to epithelial tissues. Recent evidence suggests that regulated changes in BM architecture can direct tissue morphogenesis, but the mechanisms by which cells ...
Horne-Badovinac, Sally +1 more
core +1 more source
Scientific Reports, 2018 Perlecan (HSPG2), a heparan sulfate proteoglycan, is a component of basement membranes and participates in a variety of biological activities. Here, we show physiological roles of perlecan in both obesity and the onset of metabolic syndrome.
Y. Yamashita +7 more
semanticscholar +1 more source
Extracellular matrix and nuclear abnormalities in skeletal muscle of a patient with Walker–Warburg syndrome caused by POMT1 mutation [PDF]
, 2003 Walker–Warburg syndrome (WWS) is an autosomal recessive disorder characterized by congenital muscular dystrophy, structural eye abnormalities and severe brain malformations.
Sabatelli, Patrizia +9 more
core +6 more sources
Extracellular Matrix Molecules Facilitating Vascular Biointegration
Journal of Functional Biomaterials, 2012 All vascular implants, including stents, heart valves and graft materials exhibit suboptimal biocompatibility that significantly reduces their clinical efficacy.
Martin K.C. Ng +3 more
doaj +1 more source