Decorin-evoked paternally expressed gene 3 (PEG3) is an upstream regulator of the transcription factor EB (TFEB) in endothelial cell autophagy. [PDF]
, 2017 Macroautophagy is a fundamental and evolutionarily conserved catabolic process that eradicates damaged and aging macromolecules and organelles in eukaryotic cells.
Iozzo, Renato V. +3 more
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Endothelial cells interact with the core protein of basement membrane perlecan through beta 1 and beta 3 integrins: an adhesion modulated by glycosaminoglycan. [PDF]
, 1992 K Hayashi +2 more
openalex +1 more source
Engineered short forms of perlecan enhance angiogenesis by potentiating growth factor signalling.
Journal of Controlled Release, 2023 Ha Na Kim +13 more
semanticscholar +1 more source
Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-B
eLife, 2019 The immunoreceptor tyrosine-based inhibition motif (ITIM)-containing receptor G6b-B is critical for platelet production and activation. Loss of G6b-B results in severe macrothrombocytopenia, myelofibrosis and aberrant platelet function in mice and humans.
Timo Vögtle +27 more
doaj +1 more source
Journal of Lipid Research, 2015 Perlecan is a major heparan sulfate (HS) proteoglycan in the arterial wall. Previous studies have linked it to atherosclerosis. Perlecan contains a core protein and three HS side chains. Its core protein has five domains (DI–DV) with disparate structures
Yu-Xin Xu +8 more
doaj
Glycosaminoglycans and Proteoglycans
Pharmaceuticals, 2018 In this editorial to MDPI Pharmaceuticals special issue “Glycosaminoglycans and Proteoglycans” we describe in outline the common structural features of glycosaminoglycans and the characteristics of proteoglycans, including the intracellular proteoglycan,
Vitor H. Pomin, Barbara Mulloy
doaj +1 more source
Investigating the Expression and Function of CCN2 in Articular Cartilage
, 2009 The pericellular matrix (PCM) is a distinct zone of matrix that surrounds individual chondrocytes throughout articular cartilage. Although not much is known about its function, our group has shown that it has a role in mechanotransduction by controlling ...
McLean, Celia, McLean, Celia
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Perlecan Domain V Therapy for Stroke: A Beacon of Hope? [PDF]
ACS Chemical Neuroscience, 2012 The sad reality is that in the year 2012, people are still dying or suffering from the extreme morbidity of ischemic stroke. This tragedy is only compounded by the graveyard full of once promising new therapies. While it is indeed true that the overall mortality from stroke has declined in the United States, perhaps due to increased awareness of stroke
openaire +3 more sources
Noncrystalline uric acid inhibits proteoglycan and glycosaminoglycan synthesis in distal tubular epithelial cells (MDCK) [PDF]
, 2010 Hyperuricemia is associated with renal stones, not only consisting of uric acid (UrAc) but also of calcium oxalate (CaOx). Glycosaminoglycans (GAGs) are well-known inhibitors of growth and aggregation of CaOx crystals.
Borges, Fernanda Teixeira +3 more
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