Results 11 to 20 of about 7,639 (196)
Atherosclerosis in perlecan heterozygous mice [PDF]
Journal of Lipid Research, 2004 The hypothesis that lipoprotein association with perlecan is atherogenic was tested by studying atherosclerosis in mice that had a heterozygous deletion of perlecan, the primary extracellular heparan sulfate proteoglycan in arteries. We first studied the
Reeba K. Vikramadithyan +6 more
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Maternal serum perlecan levels in women with preeclampsia
Hypertension in Pregnancy, 2020 Objective: Perlecan is an extracellular matrix proteoglycan suggested to maintain endothelial functions. We aimed to measure maternal serum perlecan levels in different preeclampsia phenotypes.
Murat Akbas +4 more
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Perlecan and the Blood-Brain Barrier: Beneficial Proteolysis? [PDF]
Frontiers in Pharmacology, 2012 The cerebral microvasculature is important for maintaining brain homeostasis. This is achieved via the blood-brain barrier (BBB), composed of endothelial cells with specialized tight junctions, astrocytes and a basement membrane.
Jill eRoberts +4 more
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SHh activity and localization is regulated by perlecan [PDF]
Biological Research, 2011 Proliferation and cell fate determination in the developing embryo are extrinsically regulated by multiple interactions among diverse secreted factors, such as Sonic Hedgehog (SHh), which act in a concentration-dependent manner.
Verónica Palma +5 more
doaj +14 more sources
The extracellular matrix component perlecan/HSPG2 regulates radioresistance in prostate cancer cells [PDF]
Frontiers in Cell and Developmental BiologyRadiotherapy of prostate cancer (PC) can lead to the acquisition of radioresistance through molecular mechanisms that involve, in part, cell adhesion-mediated signaling.
Ivana Samaržija +18 more
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Developmental expression of perlecan during murine embryogenesis [PDF]
Developmental Dynamics, 1997 Perlecan is a modular heparan sulfate proteoglycan that is an intrinsic constituent of all basement membranes and extracellular matrices. Because of its strategic position and unique structure, perlecan has been implicated in modulating the activity of various growth factors required for normal development and tissue homeostasis.
Melissa Handler +2 more
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3D distribution of perlecan within intervertebral disc chondrons suggests novel regulatory roles for this multifunctional modular heparan sulphate proteoglycan [PDF]
European Cells & Materials, 2021 Perlecan is a modular, multifunctional heparan sulphate-proteoglycan (HS-PG) that is present in the pericellular and wider extracellular matrix of connective tissues.
AJ Hayes, J Melrose
doaj +1 more source
Perlecan-Deficient Mutation Impairs Corneal Epithelial Structure [PDF]
Investigative Opthalmology & Visual Science, 2012 To elucidate the role of perlecan (Hspg2), a large multidomain heparan sulfate proteoglycan expressed in the basement membrane, in the structure of the corneal epithelium.A previously developed perlecan-deficient (Hspg2⁻/⁻-Tg) mouse model was used. Histologic analysis of their corneas was performed by light and transmission electron microscopy.
Takenori Inomata +8 more
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Frontiers in Cell and Developmental Biology, 2022 This review highlights the multifunctional properties of perlecan (HSPG2) and its potential roles in repair biology. Perlecan is ubiquitous, occurring in vascular, cartilaginous, adipose, lymphoreticular, bone and bone marrow stroma and in neural tissues.
Anthony J. Hayes +5 more
doaj +1 more source
Chondroitin sulfate perlecan enhances collagen fibril formation. Implications for perlecan chondrodysplasias. [PDF]
The Journal of biological chemistry, 2006 Inactivation of the perlecan gene leads to perinatal lethal chondrodysplasia. The similarity to the phenotypes of the Col2A1 knock-out and the disproportionate micromelia mutation suggests perlecan involvement in cartilage collagen matrix assembly.
Kvist, A. J. +10 more
openaire +7 more sources