Atherosclerosis in perlecan heterozygous mice [PDF]
Journal of Lipid Research, 2004 The hypothesis that lipoprotein association with perlecan is atherogenic was tested by studying atherosclerosis in mice that had a heterozygous deletion of perlecan, the primary extracellular heparan sulfate proteoglycan in arteries. We first studied the
Reeba K. Vikramadithyan +6 more
doaj +4 more sources
The multifaceted roles of perlecan in fibrosis [PDF]
Matrix Biology, 2018 Perlecan, or heparan sulfate proteoglycan 2 (HSPG2), is a ubiquitous heparan sulfate proteoglycan that has major roles in tissue and organ development and wound healing by orchestrating the binding and signaling of mitogens and morphogens to cells in a ...
Al-Ahmad +217 more
core +7 more sources
Maternal serum perlecan levels in women with preeclampsia
Hypertension in Pregnancy, 2020 Objective: Perlecan is an extracellular matrix proteoglycan suggested to maintain endothelial functions. We aimed to measure maternal serum perlecan levels in different preeclampsia phenotypes.
Murat Akbas +4 more
doaj +5 more sources
Perlecan: a review of its role in neurologic and musculoskeletal disease
Frontiers in Physiology, 2023 Perlecan is a 500 kDa proteoglycan residing in the extracellular matrix of endothelial basement membranes with five distinct protein domains and three heparan sulfate chains.
Tessa R. Lavorgna +7 more
doaj +3 more sources
Perlecan and the Blood-Brain Barrier: Beneficial Proteolysis? [PDF]
Frontiers in Pharmacology, 2012 The cerebral microvasculature is important for maintaining brain homeostasis. This is achieved via the blood-brain barrier (BBB), composed of endothelial cells with specialized tight junctions, astrocytes and a basement membrane.
Jill eRoberts +4 more
doaj +4 more sources
SHh activity and localization is regulated by perlecan [PDF]
Biological Research, 2011 Proliferation and cell fate determination in the developing embryo are extrinsically regulated by multiple interactions among diverse secreted factors, such as Sonic Hedgehog (SHh), which act in a concentration-dependent manner.
Verónica Palma +5 more
doaj +15 more sources
Life without Perlecan Has Its Problems [PDF]
The Journal of Cell Biology, 1999 Perlecan is a large heparan sulfate proteoglycan with a wide tissue distribution and multiple potential functions (see [Iozzo 1998][1]). The glycosaminoglycan chains, located in the NH2-terminal domain of the core protein, bind basic FGF-2 and have been shown to promote the mitogenic and ...
Bjørn R. Olsen
openalex +4 more sources
Developmental expression of perlecan during murine embryogenesis [PDF]
Developmental Dynamics, 1997 Perlecan is a modular heparan sulfate proteoglycan that is an intrinsic constituent of all basement membranes and extracellular matrices. Because of its strategic position and unique structure, perlecan has been implicated in modulating the activity of various growth factors required for normal development and tissue homeostasis.
Melissa Handler +2 more
openalex +4 more sources
Quantitative evaluation of experimental choroidal neovascularization by confocal scanning laser ophthalmoscopy: fluorescein angiogram parallels heparan sulfate proteoglycan expression [PDF]
Brazilian Journal of Medical and Biological Research, 2010 The objective of the present study was to develop a quantitative method to evaluate laser-induced choroidal neovascularization (CNV) in a rat model using Heidelberg Retina Angiograph 2 (HRA2) imaging.
C.V. Regatieri +8 more
doaj +4 more sources
3D distribution of perlecan within intervertebral disc chondrons suggests novel regulatory roles for this multifunctional modular heparan sulphate proteoglycan [PDF]
European Cells & Materials, 2021 Perlecan is a modular, multifunctional heparan sulphate-proteoglycan (HS-PG) that is present in the pericellular and wider extracellular matrix of connective tissues.
AJ Hayes, J Melrose
doaj +1 more source