Results 21 to 30 of about 16,351 (268)

Cancer Metastasis: The Role of the Extracellular Matrix and the Heparan Sulfate Proteoglycan Perlecan

Frontiers in Oncology, 2020
Cancer metastasis is the dissemination of tumor cells to new sites, resulting in the formation of secondary tumors. This process is complex and is spatially and temporally regulated by intrinsic and extrinsic factors.
Zehra Elgundi, Michael Papanicolaou, Michael Papanicolaou, Gretel Major, Thomas R. Cox, Thomas R. Cox, James Melrose, James Melrose, John M. Whitelock, Brooke L. Farrugia, Brooke L. Farrugia   +10 more
doaj   +2 more sources

Perlecan and the Blood-Brain Barrier: Beneficial Proteolysis? [PDF]

Frontiers in Pharmacology, 2012
The cerebral microvasculature is important for maintaining brain homeostasis. This is achieved via the blood-brain barrier (BBB), composed of endothelial cells with specialized tight junctions, astrocytes and a basement membrane.
Jill eRoberts, Michael P. Kahle, Michael P. Kahle, Gregory J. Bix, Gregory J. Bix   +4 more
doaj   +4 more sources

Perlecan (HSPG2) promotes structural, contractile, and metabolic development of human cardiomyocytes

Cell Reports
Summary: Perlecan (HSPG2), a heparan sulfate proteoglycan similar to agrin, is key for extracellular matrix (ECM) maturation and stabilization. Although crucial for cardiac development, its role remains elusive. We show that perlecan expression increases
Benjamin B. Johnson, Marie-Victoire Cosson, Lorenza I. Tsansizi, Terri L. Holmes, Tegan Gilmore, Katherine Hampton, Ok-Ryul Song, Nguyen T.N. Vo, Aishah Nasir, Alzbeta Chabronova, Chris Denning, Mandy J. Peffers, Catherine L.R. Merry, John Whitelock, Linda Troeberg, Stuart A. Rushworth, Andreia S. Bernardo, James G.W. Smith   +17 more
doaj   +2 more sources

SHh activity and localization is regulated by perlecan [PDF]

Biological Research, 2011
Proliferation and cell fate determination in the developing embryo are extrinsically regulated by multiple interactions among diverse secreted factors, such as Sonic Hedgehog (SHh), which act in a concentration-dependent manner.
Verónica Palma, Héctor Carrasco, Gisela Reinchisi, Gonzalo Olivares, Fernando Faunes, Juan Larraín   +5 more
doaj   +15 more sources

Modular Proteoglycan Perlecan/HSPG2: Mutations, Phenotypes, and Functions [PDF]

Genes, 2018
Heparan sulfate proteoglycan 2 (HSPG2) is an essential, highly conserved gene whose expression influences many developmental processes including the formation of the heart and brain.
Jerahme R. Martinez, Akash Dhawan, M. Farach‐Carson   +2 more
semanticscholar   +4 more sources

SULF1 suppresses Wnt3A-driven growth of bone metastatic prostate cancer in perlecan-modified 3D cancer-stroma-macrophage triculture models.

PLoS ONE, 2020
Bone marrow stroma influences metastatic prostate cancer (PCa) progression, latency, and recurrence. At sites of PCa bone metastasis, cancer-associated fibroblasts and tumor-associated macrophages interact to establish a perlecan-rich desmoplastic stroma.
Fabio Henrique Brasil da Costa, Michael S Lewis, Anna Truong, Daniel D Carson, Mary C Farach-Carson   +4 more
doaj   +2 more sources

Quantitative evaluation of experimental choroidal neovascularization by confocal scanning laser ophthalmoscopy: fluorescein angiogram parallels heparan sulfate proteoglycan expression [PDF]

Brazilian Journal of Medical and Biological Research, 2010
The objective of the present study was to develop a quantitative method to evaluate laser-induced choroidal neovascularization (CNV) in a rat model using Heidelberg Retina Angiograph 2 (HRA2) imaging.
C.V. Regatieri, J.L. Dreyfuss, G.B. Melo, D. Lavinsky, S.K. Hossaka, E.B. Rodrigues, M.E. Farah, M. Maia, H.B. Nader   +8 more
doaj   +3 more sources

A Biomimetic Approach toward Enhancing Angiogenesis: Recombinantly Expressed Domain V of Human Perlecan Is a Bioactive Molecule That Promotes Angiogenesis and Vascularization of Implanted Biomaterials

Advanced Science, 2020
Angiogenic therapy involving delivery of pro‐angiogenic growth factors to stimulate new blood vessel formation in ischemic disease is promising but has seen limited clinical success due to issues associated with the need to deliver supra‐physiological ...
Xiaoting Lin, Fengying Tang, Shouyuan Jiang, Heba Khamis, Andre Bongers, John M. Whitelock, Megan S. Lord, Jelena Rnjak‐Kovacina   +7 more
doaj   +2 more sources

Matrilysin/MMP-7 Cleavage of Perlecan/HSPG2 Complexed with Semaphorin 3A Supports FAK-Mediated Stromal Invasion by Prostate Cancer Cells

Scientific Reports, 2018
Interrupting the interplay between cancer cells and extracellular matrix (ECM) is a strategy to halt tumor progression and stromal invasion. Perlecan/heparan sulfate proteoglycan 2 (HSPG2) is an extracellular proteoglycan that orchestrates tumor ...
Brian J. Grindel, Jerahme R. Martinez, Tristen V. Tellman, Daniel A. Harrington, Hamim Zafar, Luay Nakhleh, Leland W. Chung, Mary C. Farach-Carson   +7 more
doaj   +2 more sources

Perlecan: An Islet Basement Membrane Protein with Protective Anti-Inflammatory Characteristics [PDF]

Bioengineering
Throughout the isolation process, human islets are subjected to destruction of the islet basement membrane (BM) and reduced oxygen supply. Reconstruction of the BM represents an option to improve islet function and survival post-transplant and may ...
Daniel Brandhorst, Heide Brandhorst, Samuel Acreman, Paul R. V. Johnson   +3 more
doaj   +2 more sources