Results 21 to 30 of about 14,656 (238)

Matrix: a complex amalgam of structures and functions in tumor microenvironment. [PDF]

FEBS Open Bio
The matrix is a dynamic, intricate three‐dimensional mesh of biomolecules with both structural and functional properties. This review deals with the complexity of this ‘molecular amalgam’ in the tumor microenvironment and highlights its importance in the maintenance and evolution of tumors by describing certain matrix biomolecules, such as ...
Skandalis SS, Tsoukala E, Sarantopoulou TD, Christopoulou ME.   +3 more
europepmc   +2 more sources

Perlecan, A Multi-Functional, Cell-Instructive, Matrix-Stabilizing Proteoglycan With Roles in Tissue Development Has Relevance to Connective Tissue Repair and Regeneration

Frontiers in Cell and Developmental Biology, 2022
This review highlights the multifunctional properties of perlecan (HSPG2) and its potential roles in repair biology. Perlecan is ubiquitous, occurring in vascular, cartilaginous, adipose, lymphoreticular, bone and bone marrow stroma and in neural tissues.
Anthony J. Hayes, Brooke L. Farrugia, Ifechukwude J. Biose, Gregory J. Bix, James Melrose, James Melrose   +5 more
doaj   +1 more source

Decoding tumor-stroma interactions: from molecular crosstalk to therapeutic targets. [PDF]

FEBS Open Bio
With this “In the Limelight: Tumor‐Stroma Interactions” special issue, FEBS Open Bio aims to highlight the relevance of the tumor stroma cells, and their interactions with the tumor cells, in the progression of cancer.
Fabregat I.
europepmc   +2 more sources

Novel interactions of perlecan: Unraveling perlecan's role in angiogenesis [PDF]

Microscopy Research and Technique, 2008
AbstractPerlecan, a highly conserved and ubiquitous basement membrane heparan sulfate proteoglycan, is essential for life, inasmuch as its absence results in embryonic lethality in mice and C. elegans, and neonatal lethality in humans. Perlecan plays an essential role in vasculogenesis and chondrogenesis, as well as in pathological states where these ...
Gregory J. Bix, Renato V. Iozzo
openaire   +3 more sources

Perlecan and Tumor Angiogenesis [PDF]

Journal of Histochemistry & Cytochemistry, 2003
Perlecan is a major heparan sulfate proteoglycan (HSPG) of basement membranes (BMs) and connective tissues. The core protein of perlecan is divided into five domains based on sequence homology to other known proteins. Commonly, the N-terminal domain I of mammalian perlecan is substituted with three HS chains that can bind a number of matrix molecules,
Jiang, Xinnong, Couchman, John R
openaire   +3 more sources

Loss of the extracellular matrix protein Perlecan disrupts axonal and synaptic stability during Drosophila development

eLife, 2023
Heparan sulfate proteoglycans (HSPGs) form essential components of the extracellular matrix (ECM) and basement membrane (BM) and have both structural and signaling roles.
Ellen J Guss, Yulia Akbergenova, Karen L Cunningham, J Troy Littleton   +3 more
doaj   +1 more source

Proteomic identification of membrane-associated placental protein 4 (MP4) as perlecan and characterization of its placental expression in normal and pathologic pregnancies [PDF]

PeerJ, 2019
Background More than 50 human placental proteins were isolated and physico-chemically characterized in the 70–80s by Hans Bohn and co-workers. Many of these proteins turned to have important role in placental functions and diagnostic significance in ...
Nikolett Lilla Szenasi, Eszter Toth, Andrea Balogh, Kata Juhasz, Katalin Karaszi, Oliver Ozohanics, Zsolt Gelencser, Peter Kiraly, Beata Hargitai, Laszlo Drahos, Petronella Hupuczi, Ilona Kovalszky, Zoltan Papp, Nandor Gabor Than   +13 more
doaj   +2 more sources

Perlecan in the Natural and Cell Therapy Repair of Human Adult Articular Cartilage: Can Modifications in This Proteoglycan Be a Novel Therapeutic Approach?

Biomolecules, 2021
Articular cartilage is considered to have limited regenerative capacity, which has led to the search for therapies to limit or halt the progression of its destruction.
John Garcia, Helen S. McCarthy, Jan Herman Kuiper, James Melrose, Sally Roberts   +4 more
doaj   +1 more source

Perlecan is critical for heart stability [PDF]

Cardiovascular Research, 2008
Perlecan is a heparansulfate proteoglycan found in basement membranes, cartilage, and several mesenchymal tissues that form during development, tumour growth, and tissue repair. Loss-of-function mutations in the perlecan gene in mice are associated with embryonic lethality caused primarily by cardiac abnormalities probably due to hemopericards. The aim
Yun Fan, Klaus Addicks, Toktam Bostani, Philipp Sasse, Gottfried Brem, Attila Aszódi, Martin Breitbach, Wilhelm Roell, Mercedes Costell, Armin Welz, Erika Gustafsson, Bernd K. Fleischmann, Michaela Fleischmann, Wilhelm Bloch, Juergen Hescheler, Thomas Kolbe, Daniela Malan, Daniela Malan   +17 more
openaire   +3 more sources

Increased Risk of Aortic Dissection with Perlecan Deficiency [PDF]

International Journal of Molecular Sciences, 2021
Perlecan (HSPG2), a basement membrane-type heparan sulfate proteoglycan, has been implicated in the development of aortic tissue. However, its role in the development and maintenance of the aortic wall remains unknown. Perlecan-deficient mice (Hspg2−/−-Tg: Perl KO) have been found to show a high frequency (15–35%) of aortic dissection (AD).
Risa Nonaka, Takafumi Iesaki, Aurelien Kerever, Eri Arikawa-Hirasawa   +3 more
openaire   +2 more sources