Results 21 to 30 of about 7,639 (196)

Novel interactions of perlecan: Unraveling perlecan's role in angiogenesis [PDF]

Microscopy Research and Technique, 2008
AbstractPerlecan, a highly conserved and ubiquitous basement membrane heparan sulfate proteoglycan, is essential for life, inasmuch as its absence results in embryonic lethality in mice and C. elegans, and neonatal lethality in humans. Perlecan plays an essential role in vasculogenesis and chondrogenesis, as well as in pathological states where these ...
Gregory, Bix, Renato V, Iozzo
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Loss of the extracellular matrix protein Perlecan disrupts axonal and synaptic stability during Drosophila development

eLife, 2023
Heparan sulfate proteoglycans (HSPGs) form essential components of the extracellular matrix (ECM) and basement membrane (BM) and have both structural and signaling roles.
Ellen J Guss, Yulia Akbergenova, Karen L Cunningham, J Troy Littleton   +3 more
doaj   +1 more source

Perlecan and Tumor Angiogenesis [PDF]

Journal of Histochemistry & Cytochemistry, 2003
Perlecan is a major heparan sulfate proteoglycan (HSPG) of basement membranes (BMs) and connective tissues. The core protein of perlecan is divided into five domains based on sequence homology to other known proteins. Commonly, the N-terminal domain I of mammalian perlecan is substituted with three HS chains that can bind a number of matrix molecules,
Jiang, Xinnong, Couchman, John R
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Proteomic identification of membrane-associated placental protein 4 (MP4) as perlecan and characterization of its placental expression in normal and pathologic pregnancies [PDF]

PeerJ, 2019
Background More than 50 human placental proteins were isolated and physico-chemically characterized in the 70–80s by Hans Bohn and co-workers. Many of these proteins turned to have important role in placental functions and diagnostic significance in ...
Nikolett Lilla Szenasi, Eszter Toth, Andrea Balogh, Kata Juhasz, Katalin Karaszi, Oliver Ozohanics, Zsolt Gelencser, Peter Kiraly, Beata Hargitai, Laszlo Drahos, Petronella Hupuczi, Ilona Kovalszky, Zoltan Papp, Nandor Gabor Than   +13 more
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Perlecan in the Natural and Cell Therapy Repair of Human Adult Articular Cartilage: Can Modifications in This Proteoglycan Be a Novel Therapeutic Approach?

Biomolecules, 2021
Articular cartilage is considered to have limited regenerative capacity, which has led to the search for therapies to limit or halt the progression of its destruction.
John Garcia, Helen S. McCarthy, Jan Herman Kuiper, James Melrose, Sally Roberts   +4 more
doaj   +1 more source

Perlecan maintains microvessel integrity in vivo and modulates their formation in vitro. [PDF]

PLoS ONE, 2013
Perlecan is a heparan sulfate proteoglycan assembled into the vascular basement membranes (BMs) during vasculogenesis. In the present study we have investigated vessel formation in mice, teratomas and embryoid bodies (EBs) in the absence of perlecan.
Erika Gustafsson, Maylin Almonte-Becerril, Wilhelm Bloch, Mercedes Costell   +3 more
doaj   +1 more source

Targeting Perlecan in Human Keratinocytes Reveals Novel Roles for Perlecan in Epidermal Formation [PDF]

Journal of Biological Chemistry, 2006
Heparin-binding growth factors are crucial for the formation of human epidermis, but little is known about the role of heparan sulfate proteoglycans in this process. Here we investigated the role of the heparan sulfate proteoglycan, perlecan, in the formation of human epidermis, by utilizing in vitro engineered human skin.
Ifat, Sher, Simona, Zisman-Rozen, Liat, Eliahu, John M, Whitelock, Nicole, Maas-Szabowski, Yoshihiko, Yamada, Dirk, Breitkreutz, Norbert E, Fusenig, Eri, Arikawa-Hirasawa, Renato V, Iozzo, Reuven, Bergman, Dina, Ron   +11 more
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Hypoxia-Induced Biosynthesis of the Extracellular Matrix Molecules, Perlecan and Fibronectin, Promotes the Growth of Pleomorphic Adenoma Cells In Vitro Models

Biomedicines, 2023
Salivary pleomorphic adenoma is histopathologically characterized by its colorful stroma with myxoid, chondroid, and hyaline appearances, due to enhanced biosynthesis of extracellular matrix (ECM) molecules and poor vascularity. Thus, pleomorphic adenoma
Satoshi Maruyama, Manabu Yamazaki, Tatsuya Abé, Jun Cheng, Takashi Saku, Jun-ichi Tanuma   +5 more
doaj   +1 more source

Perlecan is critical for heart stability [PDF]

Cardiovascular Research, 2008
Perlecan is a heparansulfate proteoglycan found in basement membranes, cartilage, and several mesenchymal tissues that form during development, tumour growth, and tissue repair. Loss-of-function mutations in the perlecan gene in mice are associated with embryonic lethality caused primarily by cardiac abnormalities probably due to hemopericards. The aim
Sasse, P., Malan, D., Fleischmann, M., Roell, W., Gustafsson, E., Bostani, T., Fan, Y., Kolbe, T., Breitbach, M., Addicks, K., Welz, A., Brem, G., Hescheler, J., Aszodi, A., Costell, M., Bloch, W., Fleischmann, B.   +16 more
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Increased Risk of Aortic Dissection with Perlecan Deficiency [PDF]

International Journal of Molecular Sciences, 2021
Perlecan (HSPG2), a basement membrane-type heparan sulfate proteoglycan, has been implicated in the development of aortic tissue. However, its role in the development and maintenance of the aortic wall remains unknown. Perlecan-deficient mice (Hspg2−/−-Tg: Perl KO) have been found to show a high frequency (15–35%) of aortic dissection (AD).
Risa Nonaka, Takafumi Iesaki, Aurelien Kerever, Eri Arikawa-Hirasawa   +3 more
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