Results 31 to 40 of about 7,639 (196)
Molecular Cancer, 2006 Background Genetic studies associated the CAPB locus with familial risk of brain and prostate cancers. We have identified HSPG2 (Perlecan) as a candidate gene for CAPB. Previously we have linked Perlecan to Hedgehog signaling in Drosophila. More recently,
Farach-Carson Cindy +9 more
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Agrin and perlecan mediate tumorigenic processes in oral squamous cell carcinoma. [PDF]
PLoS ONE, 2014 Oral squamous cell carcinoma is the most common type of cancer in the oral cavity, representing more than 90% of all oral cancers. The characterization of altered molecules in oral cancer is essential to understand molecular mechanisms underlying tumor ...
Rebeca Kawahara +12 more
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Matrix: a complex amalgam of structures and functions in tumor microenvironment. [PDF]
FEBS Open BioThe matrix is a dynamic, intricate three‐dimensional mesh of biomolecules with both structural and functional properties. This review deals with the complexity of this ‘molecular amalgam’ in the tumor microenvironment and highlights its importance in the maintenance and evolution of tumors by describing certain matrix biomolecules, such as ...
Skandalis SS +3 more
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Cells, 2020 Perlecan is an extracellular matrix molecule anchored to the sarcolemma by a dystrophin–glycoprotein complex. Perlecan-deficient mice are tolerant to muscle atrophy, suggesting that perlecan negatively regulates mechanical stress-dependent skeletal ...
Satoshi Nakada +4 more
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Perlecan a multifunctional extracellular proteoglycan scaffold [PDF]
Glycobiology, 2007 Perlecan is a large multidomain heparan sulfate proteoglycan of the extracellular matrix. Expression of this proteoglycan changes dynamically during embryo implantation and placentation. Perlecan is expressed by various cells of the embryo including trophectoderm and trophoblast as well as the maternal compartment, including basal lamina underlying ...
Mary C, Farach-Carson, Daniel D, Carson
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Indian Journal of Dental Research, 2011 Perlecan means pearl-like structures. Perlecan is a large proteoglycan (400-500 kDa) present in virtually all vascularized tissues with a distribution that is primarily confined to basement membranes including those of oral mucosa.
Mithilesh Mishra +4 more
doaj +1 more source
The multifaceted roles of perlecan in fibrosis [PDF]
Matrix Biology, 2018 Perlecan, or heparan sulfate proteoglycan 2 (HSPG2), is a ubiquitous heparan sulfate proteoglycan that has major roles in tissue and organ development and wound healing by orchestrating the binding and signaling of mitogens and morphogens to cells in a temporal and dynamic fashion.
Lord, MS +5 more
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Diverse Cell Signaling Events Modulated by Perlecan [PDF]
Biochemistry, 2008 Perlecan is a ubiquitous pericellular proteoglycan ideally placed to mediate cell signaling events controlling migration, proliferation, and differentiation. Its control of growth factor signaling usually involves interactions with the heparan sulfate chains covalently coupled to the protein core's N-terminus.
John M, Whitelock +2 more
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Pericellular colocalisation and interactive properties of type VI collagen and perlecan in the intervertebral disc [PDF]
European Cells & Materials, 2016 The aim of this study was to immunolocalise type VI collagen and perlecan and determine their interactive properties in the intervertebral disc (IVD).
AJ Hayes +5 more
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A Novel Pathogenic HSPG2 Mutation in Schwartz–Jampel Syndrome
Frontiers in Neurology, 2021 Schwartz–Jampel syndrome is a rare autosomal recessive disease caused by mutation in the heparan sulfate proteoglycan 2 (HSPG2) gene. Its cardinal symptoms are skeletal dysplasia and neuromuscular hyperactivity.
Po-Yu Lin +7 more
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