Results 31 to 40 of about 14,656 (238)
Diverse Cell Signaling Events Modulated by Perlecan [PDF]
Biochemistry, 2008 Perlecan is a ubiquitous pericellular proteoglycan ideally placed to mediate cell signaling events controlling migration, proliferation, and differentiation. Its control of growth factor signaling usually involves interactions with the heparan sulfate chains covalently coupled to the protein core's N-terminus.
John M. Whitelock +2 more
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Perlecan a multifunctional extracellular proteoglycan scaffold [PDF]
Glycobiology, 2007 Perlecan is a large multidomain heparan sulfate proteoglycan of the extracellular matrix. Expression of this proteoglycan changes dynamically during embryo implantation and placentation. Perlecan is expressed by various cells of the embryo including trophectoderm and trophoblast as well as the maternal compartment, including basal lamina underlying ...
Mary C. Farach‐Carson +1 more
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Chondroitin Sulfate Perlecan Enhances Collagen Fibril Formation [PDF]
Journal of Biological Chemistry, 2006 Inactivation of the perlecan gene leads to perinatal lethal chondrodysplasia. The similarity to the phenotypes of the Col2A1 knock-out and the disproportionate micromelia mutation suggests perlecan involvement in cartilage collagen matrix assembly.
Kvist, A. J. +10 more
openaire +4 more sources
Cornea organoids from human induced pluripotent stem cells. [PDF]
, 2017 The cornea is the transparent outermost surface of the eye, consisting of a stratified epithelium, a collagenous stroma and an innermost single-cell layered endothelium and providing 2/3 of the refractive power of the eye. Multiple diseases of the cornea
Adams, Sheila M +5 more
core +9 more sources
Acetylcholinesterase Clustering at the Neuromuscular Junction Involves Perlecan and Dystroglycan [PDF]
The Journal of Cell Biology, 1999 Formation of the synaptic basal lamina at vertebrate neuromuscular junction involves the accumulation of numerous specialized extracellular matrix molecules including a specific form of acetylcholinesterase (AChE), the collagenic-tailed form. The mechanisms responsible for its localization at sites of nerve– muscle contact are not well understood.
H. Benjamin Peng +3 more
openalex +5 more sources
Targeting Perlecan in Human Keratinocytes Reveals Novel Roles for Perlecan in Epidermal Formation [PDF]
Journal of Biological Chemistry, 2006 Heparin-binding growth factors are crucial for the formation of human epidermis, but little is known about the role of heparan sulfate proteoglycans in this process. Here we investigated the role of the heparan sulfate proteoglycan, perlecan, in the formation of human epidermis, by utilizing in vitro engineered human skin.
Eri Arikawa-Hirasawa +11 more
openaire +3 more sources
Perlecan controls neurogenesis in the developing telencephalon [PDF]
BMC Developmental Biology, 2007 Abstract Background Perlecan is a proteoglycan expressed in the basal lamina of the neuroepithelium during development. Perlecan absence does not impair basal lamina assembly, although in the 55% of the mutants early disruptions of this lamina conducts to exencephaly, impairing brain development.
Cristina Gil-Sanz +5 more
openaire +4 more sources
Biomedicines, 2023 Salivary pleomorphic adenoma is histopathologically characterized by its colorful stroma with myxoid, chondroid, and hyaline appearances, due to enhanced biosynthesis of extracellular matrix (ECM) molecules and poor vascularity. Thus, pleomorphic adenoma
Satoshi Maruyama +5 more
doaj +1 more source
Structure, Mechanics, and Mechanobiology of Fibrocartilage Pericellular Matrix Mediated by Type V Collagen. [PDF]
Adv Sci (Weinh)This study defines the structure, mechanics, and mechanobiology of the fibrocartilage pericellular matrix (PCM) using the murine meniscus, showing how collagen V deficiency alters PCM properties and disrupts cell mechanosensitive signaling. Findings emphasize the critical role of PCM in fibrocartilage mechanobiology and suggest targeting it can enhance
Wang C +13 more
europepmc +2 more sources
Agrin and perlecan mediate tumorigenic processes in oral squamous cell carcinoma. [PDF]
PLoS ONE, 2014 Oral squamous cell carcinoma is the most common type of cancer in the oral cavity, representing more than 90% of all oral cancers. The characterization of altered molecules in oral cancer is essential to understand molecular mechanisms underlying tumor ...
Rebeca Kawahara +12 more
doaj +1 more source