Results 41 to 50 of about 7,639 (196)

Expression of the Heparan Sulfate Proteoglycan, Perlecan, during Mouse Embryogenesis and Perlecan Chondrogenic Activity In Vitro [PDF]

The Journal of Cell Biology, 1999
Expression of the basement membrane heparan sulfate proteoglycan (HSPG), perlecan (Pln), mRNA, and protein has been examined during murine development. Both Pln mRNA and protein are highly expressed in cartilaginous regions of developing mouse embryos, but not in areas of membranous bone formation.
M M, French, S E, Smith, K, Akanbi, T, Sanford, J, Hecht, M C, Farach-Carson, D D, Carson   +6 more
openaire   +2 more sources

Similarity of Recombinant Human Perlecan Domain 1 by Alternative Expression Systems Bioactive Heterogenous Recombinant Human Perlecan D1 [PDF]

BMC Biotechnology, 2010
AbstractBackgroundHeparan sulfate glycosaminoglycans are diverse components of certain proteoglycans and are known to interact with growth factors as a co-receptor necessary to induce signalling and growth factor activity. In this report we characterize heterogeneously glycosylated recombinant human perlecan domain 1 (HSPG2 abbreviated as rhPln.D1 ...
Ellis, April L, Pan, Wensheng, Yang, Guang, Jones, Kim, Chuang, Christine, Whitelock, John M, DeCarlo, Arthur A   +6 more
openaire   +4 more sources

Decoding tumor-stroma interactions: from molecular crosstalk to therapeutic targets. [PDF]

FEBS Open Bio
With this “In the Limelight: Tumor‐Stroma Interactions” special issue, FEBS Open Bio aims to highlight the relevance of the tumor stroma cells, and their interactions with the tumor cells, in the progression of cancer.
Fabregat I.
europepmc   +2 more sources

Life without Perlecan Has Its Problems [PDF]

The Journal of Cell Biology, 1999
Perlecan is a large heparan sulfate proteoglycan with a wide tissue distribution and multiple potential functions (see [Iozzo 1998][1]). The glycosaminoglycan chains, located in the NH2-terminal domain of the core protein, bind basic FGF-2 and have been shown to promote the mitogenic and ...
openaire   +3 more sources

Achilles and tail tendons of perlecan exon 3 null heparan sulphate deficient mice display surprising improvement in tendon tensile properties and altered collagen fibril organisation compared to C57BL/6 wild type mice [PDF]

PeerJ, 2018
The aim of this study was to determine the role of the perlecan (Hspg2) heparan sulphate (HS) side chains on cell and matrix homeostasis in tail and Achilles tendons in 3 and 12 week old Hspg2 exon 3 null HS deficient (Hspg2Δ3 − ∕Δ3 −) and C57 BL/6 Wild ...
Cindy C. Shu, Margaret M. Smith, Richard C. Appleyard, Christopher B. Little, James Melrose   +4 more
doaj   +2 more sources

Gabapentin Disrupts Binding of Perlecan to the α₂δ₁ Voltage Sensitive Calcium Channel Subunit and Impairs Skeletal Mechanosensation

Biomolecules, 2022
Our understanding of how osteocytes, the principal mechanosensors within bone, sense and perceive force remains unclear. Previous work identified “tethering elements” (TEs) spanning the pericellular space of osteocytes and transmitting mechanical ...
Perla C. Reyes Fernandez, Christian S. Wright, Adrianna N. Masterson, Xin Yi, Tristen V. Tellman, Andrei Bonteanu, Katie Rust, Megan L. Noonan, Kenneth E. White, Karl J. Lewis, Uma Sankar, Julia M. Hum, Gregory Bix, Danielle Wu, Alexander G. Robling, Rajesh Sardar, Mary C. Farach-Carson, William R. Thompson   +17 more
doaj   +1 more source

Modular Proteoglycan Perlecan/HSPG2: Mutations, Phenotypes, and Functions [PDF]

Genes, 2018
Heparan sulfate proteoglycan 2 (HSPG2) is an essential, highly conserved gene whose expression influences many developmental processes including the formation of the heart and brain. The gene is widely expressed throughout the musculoskeletal system including cartilage, bone marrow and skeletal muscle.
Jerahme R. Martinez, Akash Dhawan, Mary C. Farach-Carson   +2 more
openaire   +3 more sources

Perlecan is required for FGF-2 signaling in the neural stem cell niche

Stem Cell Research, 2014
In the adult subventricular zone (neurogenic niche), neural stem cells double-positive for two markers of subsets of neural stem cells in the adult central nervous system, glial fibrillary acidic protein and CD133, lie in proximity to fractones and to ...
Aurelien Kerever, Frederic Mercier, Risa Nonaka, Susana de Vega, Yuka Oda, Bernard Zalc, Yohei Okada, Nobutaka Hattori, Yoshihiko Yamada, Eri Arikawa-Hirasawa   +9 more
doaj   +1 more source

Extracellular matrix guidance of autophagy: a mechanism regulating cancer growth

Open Biology, 2022
The extracellular matrix (ECM) exists as a dynamic network of biophysical and biochemical factors that maintain tissue homeostasis. Given its sensitivity to changes in the intra- and extracellular space, the plasticity of the ECM can be pathological in ...
Carolyn G. Chen, Renato V. Iozzo
doaj   +1 more source

Highly Tunable and Cell‐Remodelable Thiol‐ene Alginate‐Peptide Crosslinked Hydrogels to Recreate Cellular and Organoid Microenvironments for Biofabrication

Advanced Healthcare Materials, EarlyView.
Norbornene‐functionalized alginate is crosslinked with a di‐thiolated peptide sequence cleavable by cell‐secreted matrix metalloproteinases and decorated with cell‐adhesion peptides upon exposure to UV. Thyroid follicles, endometrial and intestinal organoids are encapsulated in a gentle manner with high cell viability and correct phenotype ...
Julia Fernández‐Pérez, Adrián Seijas‐Gamardo, Antonio J. Feliciano, Panagiota Kakni, Anna M. Kip, Paul Wieringa, Stefan Giselbrecht, Matthew B. Baker, Lorenzo Moroni   +8 more
wiley   +1 more source