Results 51 to 60 of about 16,351 (268)
Agrin and perlecan mediate tumorigenic processes in oral squamous cell carcinoma. [PDF]
PLoS ONE, 2014 Oral squamous cell carcinoma is the most common type of cancer in the oral cavity, representing more than 90% of all oral cancers. The characterization of altered molecules in oral cancer is essential to understand molecular mechanisms underlying tumor ...
Rebeca Kawahara +12 more
doaj +1 more source
International Journal of Molecular Sciences, 2021 The Perlecan-Semaphorin 3A-Plexin A1-Neuropilin-1 (PSPN) Complex at the cell surface of prostate cancer (PCa) cells influences cell–cell cohesion and dyscohesion.
Tristen V. Tellman +3 more
semanticscholar +1 more source
Proteoglycan neofunctions: regulation of inflammation and autophagy in cancer biology. [PDF]
, 2017 Inflammation and autophagy have emerged as prominent issues in the context of proteoglycan signaling. In particular, two small, leucine-rich proteoglycans, biglycan and decorin, play pivotal roles in the regulation of these vital cellular pathways and ...
Cohen IR +5 more
core +2 more sources
Cells, 2020 Perlecan is an extracellular matrix molecule anchored to the sarcolemma by a dystrophin–glycoprotein complex. Perlecan-deficient mice are tolerant to muscle atrophy, suggesting that perlecan negatively regulates mechanical stress-dependent skeletal ...
Satoshi Nakada +4 more
doaj +1 more source
Indian Journal of Dental Research, 2011 Perlecan means pearl-like structures. Perlecan is a large proteoglycan (400-500 kDa) present in virtually all vascularized tissues with a distribution that is primarily confined to basement membranes including those of oral mucosa.
Mithilesh Mishra +4 more
doaj +1 more source
Epithelial organization and cyst lumen expansion require efficient Sec13-Sec31-driven secretion [PDF]
, 2012 Epithelial morphogenesis is directed by interactions with the underlying extracellular matrix. Secretion of collagen and other matrix components requires efficient coat complex II (COPII) vesicle formation at the endoplasmic reticulum. Here, we show that
Hodgson, Lorna +3 more
core +2 more sources
Genetic Suppression of Basement Membrane Defects in Caenorhabditis elegans by Gain of Function in Extracellular Matrix and Cell-Matrix Attachment Genes. [PDF]
, 2018 Basement membranes are extracellular matrices essential for embryonic development in animals. Peroxidasins are extracellular peroxidases implicated in the unique sulfilimine cross-links between type IV basement membrane collagens. Loss of function in the
Chisholm, Andrew D +3 more
core +2 more sources
International Journal of Molecular Sciences, 2021 The recent discovery of nuclear and perinuclear perlecan in annulus fibrosus and nucleus pulposus cells and its known matrix stabilizing properties in tissues introduces the possibility that perlecan may also have intracellular stabilizing or regulatory ...
A. Hayes, J. Melrose
semanticscholar +1 more source
Expression of the Heparan Sulfate Proteoglycan, Perlecan, during Mouse Embryogenesis and Perlecan Chondrogenic Activity In Vitro [PDF]
The Journal of Cell Biology, 1999 Expression of the basement membrane heparan sulfate proteoglycan (HSPG), perlecan (Pln), mRNA, and protein has been examined during murine development. Both Pln mRNA and protein are highly expressed in cartilaginous regions of developing mouse embryos, but not in areas of membranous bone formation.
Scott E. Smith +9 more
openaire +3 more sources
Review: Dystroglycan in the Nervous System [PDF]
, 2007 Dystroglycan is part of a large complex of proteins, the dystrophin-glycoprotein complex, which has been implicated in the pathogenesis of muscular dystrophies for a long time.
Matthias Samwald
core +2 more sources