Results 61 to 70 of about 7,639 (196)

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Binding of perlecan to transthyretin qin vitro [PDF]

Biochemical Journal, 1997
Transthyretin is one of two specific proteins involved in the transport of thyroid hormones in plasma; it possesses two binding sites for serum retinol-binding protein. In the present study we demonstrate that transthyretin also interacts in vitro with [35S]sulphate-labelled material from the medium of HepG2 cells.
S, Smeland, S O, Kolset, M, Lyon, K R, Norum, R, Blomhoff   +4 more
openaire   +2 more sources

Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape

The FEBS Journal, EarlyView.
The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto, Naike Casagrande, Emanuele Di Siena, Greta Carobolante, Lucrezia Camicia, Giorgia Schinello, Samanta Muzzin, Enrica Timis, Paola Spessotto, Maurizio Mongiat   +9 more
wiley   +1 more source

An environmentally-friendly perlecan protein expression

Journal of Physics: Conference Series, 2020
Abstract The risk of high sugar level exposure can affect almost all parts of the body, organ systems, tissues, to the cellular level. The exposure to high sugar level caused disturbances in the joints in the form of changes in the microcellular environment. It will cause negative impact to microcellular component of articular cartilage,
I Njoto, A Soekanto, S Ernawati, H Kalim, K Handono, D W Soeatmadji, A Abdurrachman, F Fatchiyah   +7 more
openaire   +1 more source

Perlecan: Roles in osteoarthritis and potential treating target

Life Sciences, 2023
Osteoarthritis (OA) is the most common joint disease, affecting hundreds of millions of people globally, which leads to a high cost of treatment and further medical care and an apparent decrease in patient prognosis. The recent view of OA pathogenesis is that increased vascularity, bone remodeling, and disordered turnover are influenced by multivariate
Zhao, Xiao-Xuan, Xie, Wen-Qing, Xiao, Wen-Feng, Li, Heng-Zhen, Naranmandakh, Shinen, Bruyere, Olivier, Reginster, Jean-Yves, Li, Yu-Sheng   +7 more
openaire   +2 more sources

The causative role of amyloidosis in the cardiac complications of Alzheimer's disease: a comprehensive systematic review

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic illustration of the bidirectional causative link between cerebral amyloid‐beta (Aβ) angiopathy and cardiovascular disease in Alzheimer's disease (AD). Common cardiovascular risk factors like microvascular thrombosis, diabetes, atrial fibrillation, hypertension and atherosclerosis lead to cerebral hypoperfusion and ...
Samuel Parker, Andrew F. James, Svetlana Mastitskaya   +2 more
wiley   +1 more source

Profiling of Extracellular Vesicles of Non‐Small Cell Lung Cancer Reveals Proteins Associated With Osimertinib Resistance

Journal of Extracellular Vesicles, Volume 15, Issue 1, January 2026.
Non‐invasive biomarkers are needed to further personalize EGFR tyrosine kinase inhibitor (EGFR TKI) osimertinib treatment in non‐small cell lung cancer (NSCLC) patients. By analysing the proteome of extracellular vesicles (EVs) isolated from an osimertinib resistant NSCLC cell line and from serum of patients given osimertinib in second line within the ...
Albano Cáceres‐Verschae, Petra Hååg, Sofia Joelsson, Per Hydbring, Bo Franzén, Ákos Végvári, Inger Johanne Z. Eide, Nupur Agarwal, Siddharth Sourabh Sahu, Fredrik Stridfeldt, Luigi De Petris, Apurba Dev, Simon Ekman, Odd Terje Brustugun, Rolf Lewensohn, Kristina Viktorsson   +15 more
wiley   +1 more source

基底膜蛋白多糖对肌萎缩相关因子myostatin和IGF-1信号表达的影响

Zhongguo shiyan zhenduanxue, 2022
目的 旨在观察基底膜蛋白多糖（perlecan）对小鼠肌卫星细胞中肌肉生长抑制素（myostatin）和胰岛素样生长因子-1（IGF-1，也被称为促生长因子）等肌肉萎缩相关因子信号表达的影响。方法 应用单一肌纤维卫星细胞分离培养技术，分离出高纯度肌肉卫星细胞，通过添加perlecan因子，利用蛋白免疫印迹法（Western blot）、定量RT-PCR等技术方法观察Perlecan对Myostatin和IGF-1信号表达的影响。结果 ...
许卓, 杨寿君, 石洪峰, 王月英, 平泽惠理   +4 more
doaj  

Searching urinary tumor-associated proteins for bladder transitional cell carcinoma in southwestern Taiwan using gel-based proteomics

Urological Science, 2016
Background and purpose: We try to search for specific serum or urinary biomarkers for the early detection, follow-up, and prediction of tumor recurrence, progression, and clinical outcome is a difficult task in individuals with bladder cancer.
Chia-Cheng Su, Kun-Hung Sheng, Shih-Ying Chen, Yeou-Guang Tsay, Ting-Feng Wu   +4 more
doaj   +1 more source

Principal mechanisms of extracellular matrix‐mediated cell–cell communication in physiological and tumor microenvironments

The FEBS Journal, Volume 293, Issue 1, Page 26-41, January 2026.
Intracellular communication controls the processing of generated signals so that every cell type can successfully respond. The extracellular matrix (ECM) is a fundamental regulator of cell communication and signaling through the strict orchestration and functions of its bioactive components.
Zoi Piperigkou, Sylvia Mangani, Nikolaos E. Koletsis, Christos Koutsakis, Nicholas S. Mastronikolis, Marco Franchi, Nikos K. Karamanos   +6 more
wiley   +1 more source