Results 61 to 70 of about 14,656 (238)

Similarity of Recombinant Human Perlecan Domain 1 by Alternative Expression Systems Bioactive Heterogenous Recombinant Human Perlecan D1 [PDF]

BMC Biotechnology, 2010
AbstractBackgroundHeparan sulfate glycosaminoglycans are diverse components of certain proteoglycans and are known to interact with growth factors as a co-receptor necessary to induce signalling and growth factor activity. In this report we characterize heterogeneously glycosylated recombinant human perlecan domain 1 (HSPG2 abbreviated as rhPln.D1 ...
Ellis, April L, Pan, Wensheng, Yang, Guang, Jones, Kim, Chuang, Christine, Whitelock, John M, DeCarlo, Arthur A   +6 more
openaire   +5 more sources

Trabecular Bone Deficit and Enhanced Anabolic Response to Re-Ambulation after Disuse in Perlecan-Deficient Skeleton

Biomolecules, 2020
Perlecan/Hspg2, a large monomeric heparan sulfate proteoglycan, is found in the basement membrane and extracellular matrix, where it acts as a matrix scaffold, growth factor depot, and tissue barrier.
Ashutosh Parajuli, Shaopeng Pei, Hongbo Zhao, Jerahme R. Martinez, X. Lucas Lu, X. Sherry Liu, Mary C. Farach-Carson, Catherine B. Kirn-Safran, Liyun Wang   +8 more
doaj   +1 more source

Extracellular matrix guidance of autophagy: a mechanism regulating cancer growth

Open Biology, 2022
The extracellular matrix (ECM) exists as a dynamic network of biophysical and biochemical factors that maintain tissue homeostasis. Given its sensitivity to changes in the intra- and extracellular space, the plasticity of the ECM can be pathological in ...
Carolyn G. Chen, Renato V. Iozzo
doaj   +1 more source

Artificial restoration of the linkage between laminin and dystroglycan ameliorates the disease progression of MDC1A muscular dystrophy at all stages [PDF]

, 2005
Laminin-α2 deficient congenital muscular dystrophy, classified as MDC1A, is a severe progressive muscle-wasting disease that leads to death in early childhood.
Meinen, Sarina
core   +1 more source

Perlecan (HSPG2) promotes structural, contractile, and metabolic development of human cardiomyocytes

Cell Reports
Summary: Perlecan (HSPG2), a heparan sulfate proteoglycan similar to agrin, is key for extracellular matrix (ECM) maturation and stabilization. Although crucial for cardiac development, its role remains elusive. We show that perlecan expression increases
Benjamin B. Johnson, Marie-Victoire Cosson, Lorenza I. Tsansizi, Terri L. Holmes, Tegan Gilmore, Katherine Hampton, Ok-Ryul Song, Nguyen T.N. Vo, Aishah Nasir, Alzbeta Chabronova, Chris Denning, Mandy J. Peffers, Catherine L.R. Merry, John Whitelock, Linda Troeberg, Stuart A. Rushworth, Andreia S. Bernardo, James G.W. Smith   +17 more
doaj   +1 more source

Matrilysin/MMP-7 Cleavage of Perlecan/HSPG2 Complexed with Semaphorin 3A Supports FAK-Mediated Stromal Invasion by Prostate Cancer Cells

Scientific Reports, 2018
Interrupting the interplay between cancer cells and extracellular matrix (ECM) is a strategy to halt tumor progression and stromal invasion. Perlecan/heparan sulfate proteoglycan 2 (HSPG2) is an extracellular proteoglycan that orchestrates tumor ...
Brian J. Grindel, Jerahme R. Martinez, Tristen V. Tellman, Daniel A. Harrington, Hamim Zafar, Luay Nakhleh, Leland W. Chung, Mary C. Farach-Carson   +7 more
doaj   +1 more source

Cell Autonomous Expression of Perlecan and Plasticity of Cell Shape in Embryonic Muscle ofCaenorhabditis elegans [PDF]

, 1996
Perlecan, a component of the extracellular matrix (ECM), is essential for myofilament formation and muscle attachment inCaenorhabditis elegans.We show here that perlecan is a product of muscle and that it behaves in a cell autonomous fashion.
Moerman, Donald G., Hutter, Harald, Mullen, Gregory P., Schnabel, Ralf   +3 more
core   +1 more source

SULF1 suppresses Wnt3A-driven growth of bone metastatic prostate cancer in perlecan-modified 3D cancer-stroma-macrophage triculture models.

PLoS ONE, 2020
Bone marrow stroma influences metastatic prostate cancer (PCa) progression, latency, and recurrence. At sites of PCa bone metastasis, cancer-associated fibroblasts and tumor-associated macrophages interact to establish a perlecan-rich desmoplastic stroma.
Fabio Henrique Brasil da Costa, Michael S Lewis, Anna Truong, Daniel D Carson, Mary C Farach-Carson   +4 more
doaj   +1 more source

Cancer Metastasis: The Role of the Extracellular Matrix and the Heparan Sulfate Proteoglycan Perlecan

Frontiers in Oncology, 2020
Cancer metastasis is the dissemination of tumor cells to new sites, resulting in the formation of secondary tumors. This process is complex and is spatially and temporally regulated by intrinsic and extrinsic factors.
Zehra Elgundi, Michael Papanicolaou, Michael Papanicolaou, Gretel Major, Thomas R. Cox, Thomas R. Cox, James Melrose, James Melrose, John M. Whitelock, Brooke L. Farrugia, Brooke L. Farrugia   +10 more
doaj   +1 more source

Role of glomerular proteoglycans in IgA nephropathy. [PDF]

PLoS ONE, 2011
Mesangial matrix expansion is a prominent feature of the most common form of glomerulonephritis, IgA nephropathy (IgAN). To find molecular markers and improve the understanding of the disease, the gene and protein expression of proteoglycans were ...
Kerstin Ebefors, Anna Granqvist, Madeleine Ingelsten, Johan Mölne, Börje Haraldsson, Jenny Nyström   +5 more
doaj   +1 more source