Results 61 to 70 of about 16,351 (268)

Binding of perlecan to transthyretin qin vitro [PDF]

Biochemical Journal, 1997
Transthyretin is one of two specific proteins involved in the transport of thyroid hormones in plasma; it possesses two binding sites for serum retinol-binding protein. In the present study we demonstrate that transthyretin also interacts in vitro with [35S]sulphate-labelled material from the medium of HepG2 cells.
Kaare R. Norum, Malcolm Lyon, Rune Blomhoff, Sigbjørn Smeland, Svein Olav Kolset   +4 more
openaire   +3 more sources

Prenatal muscle development in a mouse model for the secondary dystroglycanopathies [PDF]

, 2016
The defective glycosylation of α-dystroglycan is associated with a group of muscular dystrophies that are collectively referred to as the secondary dystroglycanopathies.
A Leschziner, A Matsakas, A Yoshida, AM Beedle, AR Raphael, B Xia, B-V BD de, C Godfrey, C Longman, C Whitmore, CA Schneider, D Merrick, D Montarras, DE Michele, DJ Blake, DJ Lefeber, E Hohenester, E Stevens, F Muntoni, H Yin, J Reeuwijk van, J Ross, JB Miller, K Buysse, K Kobayashi, KM Wright, KP Campbell, L Wells, M Brockington, M Brockington, M Kanagawa, M Kanagawa, M Narusawa, M Ontell, MD Henry, MJ Duxson, MM Goddeeris, MR Ackroyd, MR Ackroyd, O Armand, S Chan, S Cirak, S Costanzo Di, S Sato, S Schiaffino, S Sugita, SC Brown, T Roscioli, T Willer, TJ Hawke   +49 more
core   +1 more source

The role of perlecan in arterial injury and angiogenesis [PDF]

Cardiovascular Research, 2004
Perlecan is a large heparan sulfate proteoglycan (HSPG), which is a major component of the vessel wall. In relation to vascular biology, perlecan has been shown to be a potent inhibitor of smooth muscle cell (SMC) activity. In vivo experiments in animal models of arterial injury have shown that perlecan may inhibit thrombosis and intimal hyperplasia ...
Bradley H. Strauss, Amit Segev, Nafiseh Nili   +2 more
openaire   +3 more sources

Chemical chaperone treatment reduces intracellular accumulation of mutant collagen IV and ameliorates the cellular phenotype of a COL4A2 mutation that causes haemorrhagic stroke [PDF]

, 2013
Haemorrhagic stroke accounts for approximately 20% of stroke cases and porencephaly is a clinical consequence of perinatal cerebral haemorrhaging. Here we report the identification of a novel dominant G702D mutation in the collagen domain of COL4A2 ...
Aislynn Taggart, Bateman, Brazel, Catheline Vilain, de Clerck, Engin, Favor, Geesin, Gould, Gould, Gould, Hostikka, Ishida, Jeanne, Kalluri, Karl E. Kadler, Khoshnoodi, Lydia S. Murray, Marc Abramowicz, Muthukumaran, Nicole Van Regemorter, Ozcan, Plaisier, Plaisier, Poschl, Ron, Taylor, Tom Van Agtmael, Vahedi, Van Agtmael, Van Agtmael, Van Agtmael, Verbeek, Vilain, Woo, Yinhui Lu   +35 more
core   +1 more source

Effect of Recombinant Human Perlecan Domain V Tethering Method on Protein Orientation and Blood Contacting Activity on Polyvinyl Chloride

Advanced Healthcare Materials, 2021
Surface modification of biomaterials is a promising approach to control biofunctionality while retaining the bulk biomaterial properties. Perlecan is the major proteoglycan in the vascular basement membrane that supports low levels of platelet adhesion ...
K. Chandrasekar, B. Farrugia, L. Johnson, D. Marks, D. Irving, Z. Elgundi, K. Lau, Ha Na Kim, J. Rnjak‐Kovacina, M. Bilek, J. Whitelock, M. Lord   +11 more
semanticscholar   +1 more source

Modulation of Perlecan Protein towards Chondrocyte Secretion Factors at the Articular Cartilage in Hyperglycemic Animal Model [PDF]

Journal of Pure and Applied Chemistry Research, 2019
High carbohydrate influences the cartilage microcellular environment and chondrocytes. Perlecan (HSPG2) conducts an essential role as chondrocytes mechano-transducer and chondrocytes secretion factors. This research aims to fulfill the research gap about
Ibrahim Njoto, Fatchiyah Fatchiyah, Kusworini Handono, Abdurrachman Abdurrachman, Djoko W. Soeatmadji, Handono Kalim   +5 more
doaj   +1 more source

Gabapentin Disrupts Binding of Perlecan to the α₂δ₁ Voltage Sensitive Calcium Channel Subunit and Impairs Skeletal Mechanosensation

Biomolecules, 2022
Our understanding of how osteocytes, the principal mechanosensors within bone, sense and perceive force remains unclear. Previous work identified “tethering elements” (TEs) spanning the pericellular space of osteocytes and transmitting mechanical ...
Perla C. Reyes Fernandez, Christian S. Wright, Adrianna N. Masterson, Xin Yi, Tristen V. Tellman, Andrei Bonteanu, Katie Rust, Megan L. Noonan, Kenneth E. White, Karl J. Lewis, Uma Sankar, Julia M. Hum, Gregory Bix, Danielle Wu, Alexander G. Robling, Rajesh Sardar, Mary C. Farach-Carson, William R. Thompson   +17 more
doaj   +1 more source

EphA2 is a functional receptor for the growth factor progranulin. [PDF]

, 2016
Although the growth factor progranulin was discovered more than two decades ago, the functional receptor remains elusive. Here, we discovered that EphA2, a member of the large family of Ephrin receptor tyrosine kinases, is a functional signaling receptor
Ahmed, Al-Ayadhi, Andrea Morrione, Atul Goyal, Baker, Bateman, Bhandari, Bhandari, Bogan, Brantley, Brantley-Sieders, Brantley-Sieders, Brantley-Sieders, Brantley-Sieders, Buraschi, Carrasquillo, Catherine Sharpe, Cenik, Chan, Chen, Cheng, Cruts, Cruts, Culouscou, Dave, Dunn, Duxbury, Elizabeth Natkanski, Farach-Carson, Ferluga, Gass, Ghidoni, Gijselinck, Giorgio, Goldoni, Gonzalez, Grindel, He, He, Hess, Hu, Huang, Iozzo, Iozzo, Jun, Kessenbrock, Kohlschütter, Kullander, Lema Tomé, Lemmon, Liliana Schaefer, Lord, Lord, Lovat, Margaryan, Matsubara, Merline, Miao, Minami, Misaki, Monami, Monami, Noberini, Nykjaer, Ogawa, Park, Parri, Petty, Prudencio, Renato V. Iozzo, Romanello, Serrero, Simone Buraschi, Sleegers, Smith, Song, Taddei, Tang, Tangkeangsirisin, Tanimoto, Tanimoto, Thomas Neill, Toh, Toh, Tolkatchev, Van Damme, Van Kampen, Wang, Wesa, Whitelock, Wienken, Wilusz, Wykosky, Wykosky, Xia, Xu, Xu, Yamaguchi, Yang, Zanocco-Marani, Zinchuk, Zoeller   +101 more
core   +2 more sources

Perlecan in late stages of osteoarthritis of the human knee joint [PDF]

Osteoarthritis and Cartilage, 2004
Disturbances of the proteoglycan metabolism play an essential role in the pathology of osteoarthritis. The extracellular matrix proteoglycan, perlecan, has lately been identified as a cell biological factor in cartilage development and maintenance. We investigated the tissue distribution of perlecan, the relation between the level of the protein and ...
Florian Tesche, Nicolai Miosge
openalex   +4 more sources

Molecular interactions between perlecan LG3 and the SARS-CoV-2 spike protein receptor binding domain. [PDF]

Protein Sci, 2023
Severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) has caused a global health crisis with significant clinical morbidity and mortality. While angiotensin‐converting enzyme 2 (ACE2) is the primary receptor for viral entry, other cell surface and
Gressett TE, Hossen ML, Talkington G, Volic M, Perez H, Tiwari PB, Chapagain P, Bix G.   +7 more
europepmc   +2 more sources