Results 71 to 80 of about 7,639 (196)

A guide to building the matrisome interactome: from computational predictions to experimental validation

The FEBS Journal, Volume 293, Issue 1, Page 42-70, January 2026.
This guide proposes a roadmap combining state‐of‐the‐art computational and experimental approaches (including biophysical, biochemical, and imaging techniques) to identify, characterize, and contextualize extracellular matrix (ECM) protein interactions.
Leanna Leverton, Amanpreet Kaur Bains, Ikram Isa, Sylvie Ricard‐Blum, Alexandra Naba   +4 more
wiley   +1 more source

Exploiting Heparan Sulfate Proteoglycans in Human Neurogenesis—Controlling Lineage Specification and Fate

Frontiers in Integrative Neuroscience, 2017
Unspecialized, self-renewing stem cells have extraordinary application to regenerative medicine due to their multilineage differentiation potential.
Chieh Yu, Lyn R. Griffiths, Larisa M. Haupt   +2 more
doaj   +1 more source

Exploring neuronal mechanisms of osteosarcopenia in older adults

The Journal of Physiology, Volume 604, Issue 2, Page 672-688, 15 January 2026.
Abstract figure legend The mechanosensitive osteocytic network within the bone matrix acts as a receptor and plays a crucial role in the functional adaptation of bone to mechanical loading. Through mechanotransduction, osteocytes convert mechanical impulses into electrical signals, which are transmitted via afferent nerves to sympathetic preganglionic ...
Ilhan Karacan, Kemal Sıtkı Türker
wiley   +1 more source

A Biomimetic Approach toward Enhancing Angiogenesis: Recombinantly Expressed Domain V of Human Perlecan Is a Bioactive Molecule That Promotes Angiogenesis and Vascularization of Implanted Biomaterials

Advanced Science, 2020
Angiogenic therapy involving delivery of pro‐angiogenic growth factors to stimulate new blood vessel formation in ischemic disease is promising but has seen limited clinical success due to issues associated with the need to deliver supra‐physiological ...
Xiaoting Lin, Fengying Tang, Shouyuan Jiang, Heba Khamis, Andre Bongers, John M. Whitelock, Megan S. Lord, Jelena Rnjak‐Kovacina   +7 more
doaj   +1 more source

The Impact of the Ovine Annular Lesion Model on IVD Pathobiology and Utility of the Ovine Spinal Model in Patho‐Anatomical Studies: A Historical Perspective

JOR SPINE, Volume 8, Issue 4, December 2025.
The ovine annular rim‐lesion model of intervertebral disc degeneration of Osti and colleagues (1990) has evolved into a sophisticated mechanical destabilization large animal model of intervertebral disc degeneration over its 35 year history offering diverse musculoskeletal multi‐disciplinary investigations into the multifunctional complexity of this ...
O. Osti, C. B. Little, J. Melrose
wiley   +1 more source

Heterogeneity of Extracellular Vesicles and Non‐Vesicular Nanoparticles in Glioblastoma

Journal of Extracellular Vesicles, Volume 14, Issue 10, October 2025.
ABSTRACT It is increasingly clear that intercellular communication is largely mediated by lipid‐bilayer, membrane‐bound extracellular vesicles (EVs) and amembranous, non‐vesicular extracellular particles (NVEPs), including exomeres and the recently identified supermeres.
Tuoye Xu, Joao A. Paulo, Piyan Zhang, Xinyue Liu, Alya Nguyen, Yuanhua Cheng, Clark Massick, Yanhong Zhang, Dennis K. Jeppesen, Qin Zhang, James N. Higginbotham, Oleg S. Tutanov, Anna M. Krichevsky, Daniel T. Chiu, Steve P. Gygi, Kasey C. Vickers, Jeffrey L. Franklin, Robert J. Coffey, Al Charest   +18 more
wiley   +1 more source

An in situ hybridization study of perlecan, DMP1, and MEPE in developing condylar cartilage of the fetal mouse mandible and limb bud cartilage

European Journal of Histochemistry, 2015
The main purpose of this in situ hybridization study was to investigate mRNA expression of three bone/cartilage matrix components (perlecan, DMP1, and MEPE) in developing primary (tibial) and secondary (condylar) cartilage.
K. Fujikawa, T. Yokohama-Tamaki, T. Morita, O. Baba, C. Qin, S. Shibata   +5 more
doaj   +1 more source

Regulation of Glycoprotein VI-Dependent Platelet Activation and Thrombus Formation by Heparan Sulfate Proteoglycan Perlecan [PDF]

, 2023
Isabella Provenzale, Ilaria De Simone, Jonathan M. Gibbins, Johan W. M. Heemskerk, Paola E. J. van der Meijden, Chris I. Jones   +5 more
openalex   +1 more source

Conjugation of LG Domains of Agrins and Perlecan to Polymerizing Laminin-2 Promotes Acetylcholine Receptor Clustering [PDF]

, 2005
Sergei Smirnov, Patrizia Barzaghi, Karen K. McKee, Markus A. Rüegg, Peter D. Yurchenco   +4 more
openalex   +1 more source

Glycosaminoglycans and Proteoglycans

Pharmaceuticals, 2018
In this editorial to MDPI Pharmaceuticals special issue “Glycosaminoglycans and Proteoglycans” we describe in outline the common structural features of glycosaminoglycans and the characteristics of proteoglycans, including the intracellular proteoglycan,
Vitor H. Pomin, Barbara Mulloy
doaj   +1 more source