Results 71 to 80 of about 16,351 (268)

Achilles and tail tendons of perlecan exon 3 null heparan sulphate deficient mice display surprising improvement in tendon tensile properties and altered collagen fibril organisation compared to C57BL/6 wild type mice [PDF]

PeerJ, 2018
The aim of this study was to determine the role of the perlecan (Hspg2) heparan sulphate (HS) side chains on cell and matrix homeostasis in tail and Achilles tendons in 3 and 12 week old Hspg2 exon 3 null HS deficient (Hspg2Δ3 − ∕Δ3 −) and C57 BL/6 Wild ...
Cindy C. Shu, Margaret M. Smith, Richard C. Appleyard, Christopher B. Little, James Melrose   +4 more
doaj   +2 more sources

Heparan sulfate proteoglycan molecules, syndecan and perlecan, have distinct roles in the maintenance of Drosophila germline stem cells

Development, Growth and Differentiation, 2021
The Drosophila female germline stem cell (GSC) niche provides an excellent model for understanding the stem cell niche in vivo. The GSC niche is composed of stromal cells that provide growth factors for the maintenance of GSCs and the associated ...
Y. Hayashi, Arisa Shibata, K. Kamimura, Satoru Kobayashi   +3 more
semanticscholar   +1 more source

Heparan sulfate proteoglycans undergo differential expression alterations in left sided colorectal cancer, depending on their metastatic character [PDF]

, 2018
Background Heparan sulfate proteoglycans (HSPGs) are complex molecules which play a role in the invasion and growth and metastatic properties of cancerous cells.
Castañón de la Torre, Sonia, Crespo Susperregui, Ainara, Fernández Vega, Iván, García Fernández, Beatriz, García Suárez, Olivia, Quirós Fernández, Luis Manuel, Solis Hernández, María Pilar   +6 more
core   +2 more sources

CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan

Nature Communications, 2019
Heterogeneous subtypes of cancer-associated fibroblasts (CAFs) coexist within pancreatic cancer tissues and can both promote and restrain disease progression. Here, we interrogate how cancer cells harboring distinct alterations in p53 manipulate CAFs. We
C. Vennin, Pauline Mélénec, R. Rouet, M. Nobis, Aurélie S. Cazet, K. Murphy, D. Herrmann, Daniel A. Reed, M. Lucas, S. Warren, Z. Elgundi, M. Pinese, Gabriella Kalna, D. Roden, Monisha Samuel, Anaiis Zaratzian, S. Grey, Andrew M. Da Silva, Wilfred Leung, Amber L. Lorraine A. Angela Angela Mehreen Tanya Daniell Johns Chantrill Chou Steinmann Arshi Dwarte Froio , A. Johns, L. Chantrill, A. Chou, A. Steinmann, M. Arshi, Tanya M. Dwarte, D. Froio, Brooke A. Pereira, Shona Ritchie, C. Chambers, Xanthe L Metcalf, N. Waddell, J. Pearson, A. Patch, K. Nones, F. Newell, P. Mukhopadhyay, V. Addala, S. Kazakoff, O. Holmes, C. Leonard, S. Wood, S. Grimmond, Oliver Hofmann, Angelika N. Christ, T. Bruxner, J. Samra, N. Pavlakis, H. High, R. Asghari, N. Merrett, D. Pavey, Amitabha Das, P. Cosman, K. Ismail, Chelsie O’Connnor, A. Stoita, David B. Williams, Allan Spigellman, Vincent W. Lam, D. Mcleod, J. Kirk, J. Kench, P. Grimison, C. Cooper, C. Sandroussi, A. Goodwin, R. S. Mead, K. Tucker, L. Andrews, M. Texler, C. Forest, K. Epari, M. Ballal, D. Fletcher, Sanjay Mukhedkar, N. Zeps, M. Beilin, K. Feeney, Nan Q. Nguyen, A. Ruszkiewicz, C. Worthley, John Chen, M. Brooke-Smith, V. Papangelis, A. Clouston, A. Barbour, T. J. O'Rourke, J. Fawcett, Kellee Slater, M. Hatzifotis, Peter Hodgkinson, M. Nikfarjam, J. Eshleman, R. Hruban, elliot k fishman, R. Lawlor, S. Beghelli, V. Corbo, M. Scardoni, C. Bassi, A. Biankin, J. Dixon, N. Jamieson, D. Chang, S. Mathivanan, Yingxiao Wang, A. W. Braithwaite, D. Christ, A. Benda, A. Parkin, P. Phillips, J. Whitelock, A. Gill, O. Sansom, David R. Croucher, B. Parker, M. Pajic, J. Morton, T. Cox, P. Timpson   +120 more
semanticscholar   +1 more source

A Novel Pathogenic HSPG2 Mutation in Schwartz–Jampel Syndrome

Frontiers in Neurology, 2021
Schwartz–Jampel syndrome is a rare autosomal recessive disease caused by mutation in the heparan sulfate proteoglycan 2 (HSPG2) gene. Its cardinal symptoms are skeletal dysplasia and neuromuscular hyperactivity.
Po-Yu Lin, Jia-Horung Hung, Jia-Horung Hung, Chao-Kai Hsu, Chao-Kai Hsu, Yao-Tsung Chang, Yuan-Ting Sun, Yuan-Ting Sun   +7 more
doaj   +1 more source

Single molecule force measurements of perlecan/HSPG2: A key component of the osteocyte pericellular matrix [PDF]

, 2016
Perlecan/HSPG2, a large, monomeric heparan sulfate proteoglycan (HSPG), is a key component of the lacunar canalicular system (LCS) of cortical bone, where it is part of the mechanosensing pericellular matrix (PCM) surrounding the osteocytic processes and
Farach-Carson, Mary C., Frey, Eric W., Grindel, Brian J., Kiang, Ching-Hwa, Li, Jingqiang, Martinez, Jerahme R., Wang, Liyun, Wijeratne, Sithara S.   +7 more
core   +1 more source

Heparan Sulfate of Perlecan Is Involved in Glomerular Filtration [PDF]

Journal of the American Society of Nephrology, 2005
Perlecan is a heparan sulfate proteoglycan and a major component of the glomerular basement membrane. To understand the role of heparan sulfate chains of perlecan in glomerular filtration, detailed analyses were performed of the kidneys of
Hideto Watanabe, Raija Soininen, Terukuni Ideura, Hiroyuki Morita, Ling Wang, Kiyoko Inui, Karl Tryggvason, Ashio Yoshimura   +7 more
openaire   +3 more sources

Artificial restoration of the linkage between laminin and dystroglycan ameliorates the disease progression of MDC1A muscular dystrophy at all stages [PDF]

, 2005
Laminin-α2 deficient congenital muscular dystrophy, classified as MDC1A, is a severe progressive muscle-wasting disease that leads to death in early childhood.
Meinen, Sarina
core   +1 more source

Similarity of Recombinant Human Perlecan Domain 1 by Alternative Expression Systems Bioactive Heterogenous Recombinant Human Perlecan D1 [PDF]

BMC Biotechnology, 2010
AbstractBackgroundHeparan sulfate glycosaminoglycans are diverse components of certain proteoglycans and are known to interact with growth factors as a co-receptor necessary to induce signalling and growth factor activity. In this report we characterize heterogeneously glycosylated recombinant human perlecan domain 1 (HSPG2 abbreviated as rhPln.D1 ...
Ellis, April L, Pan, Wensheng, Yang, Guang, Jones, Kim, Chuang, Christine, Whitelock, John M, DeCarlo, Arthur A   +6 more
openaire   +5 more sources

Perlecan is required for FGF-2 signaling in the neural stem cell niche

Stem Cell Research, 2014
In the adult subventricular zone (neurogenic niche), neural stem cells double-positive for two markers of subsets of neural stem cells in the adult central nervous system, glial fibrillary acidic protein and CD133, lie in proximity to fractones and to ...
Aurelien Kerever, Frederic Mercier, Risa Nonaka, Susana de Vega, Yuka Oda, Bernard Zalc, Yohei Okada, Nobutaka Hattori, Yoshihiko Yamada, Eri Arikawa-Hirasawa   +9 more
doaj   +1 more source