Results 81 to 90 of about 16,351 (268)
Biomolecules, 2020 Perlecan/Hspg2, a large monomeric heparan sulfate proteoglycan, is found in the basement membrane and extracellular matrix, where it acts as a matrix scaffold, growth factor depot, and tissue barrier.
Ashutosh Parajuli +8 more
doaj +1 more source
Transcriptional Activation by NFκB Increases Perlecan/HSPG2 Expression in the Desmoplastic Prostate Tumor Microenvironment [PDF]
, 2014 Perlecan/HSPG2, a heparan sulfate proteoglycan typically found at tissue borders including those separating epithelia and connective tissue, increases near sites of invasion of primary prostatic tumors as previously shown for other proteins involved in ...
Carson, Daniel D. +4 more
core +1 more source
Cell Autonomous Expression of Perlecan and Plasticity of Cell Shape in Embryonic Muscle ofCaenorhabditis elegans [PDF]
, 1996 Perlecan, a component of the extracellular matrix (ECM), is essential for myofilament formation and muscle attachment inCaenorhabditis elegans.We show here that perlecan is a product of muscle and that it behaves in a cell autonomous fashion.
Moerman, Donald G. +3 more
core +2 more sources
Extracellular matrix guidance of autophagy: a mechanism regulating cancer growth
Open Biology, 2022 The extracellular matrix (ECM) exists as a dynamic network of biophysical and biochemical factors that maintain tissue homeostasis. Given its sensitivity to changes in the intra- and extracellular space, the plasticity of the ECM can be pathological in ...
Carolyn G. Chen, Renato V. Iozzo
doaj +1 more source
Cytoneme-mediated signaling essential for tumorigenesis. [PDF]
, 2019 Communication between neoplastic cells and cells of their microenvironment is critical to cancer progression. To investigate the role of cytoneme-mediated signaling as a mechanism for distributing growth factor signaling proteins between tumor and tumor ...
Fereres, Sol +3 more
core +1 more source
Current and Future Cornea Chip Models for Advancing Ophthalmic Research and Therapeutics
Advanced Biology, EarlyView.This review analyzes cornea chip technology as an innovative solution to corneal blindness and tissue scarcity. The examination encompasses recent developments in biomaterial design and fabrication methods replicating corneal architecture, highlighting applications in drug screening and disease modeling while addressing key challenges in mimicking ...
Minju Kim +3 more
wiley +1 more source
Perlecan Domain-V Enhances Neurogenic Brain Repair After Stroke in Mice
Translational Stroke Research, 2020 The extracellular matrix fragment perlecan domain V is neuroprotective and functionally restorative following experimental stroke. As neurogenesis is an important component of chronic post-stroke repair, and previous studies have implicated perlecan in ...
A. Trout +18 more
semanticscholar +1 more source
Role of glomerular proteoglycans in IgA nephropathy. [PDF]
PLoS ONE, 2011 Mesangial matrix expansion is a prominent feature of the most common form of glomerulonephritis, IgA nephropathy (IgAN). To find molecular markers and improve the understanding of the disease, the gene and protein expression of proteoglycans were ...
Kerstin Ebefors +5 more
doaj +1 more source
Biomedicines, 2023 Schwartz–Jampel syndrome (SJS) is an autosomal recessive disorder caused by loss-of-function mutations in heparan sulfate proteoglycan 2 (HSPG2), which encodes the core basement membrane protein perlecan.
Yuri Yamashita +9 more
doaj +1 more source
Advanced Science, EarlyView.This study defines the structure, mechanics, and mechanobiology of the fibrocartilage pericellular matrix (PCM) using the murine meniscus, showing how collagen V deficiency alters PCM properties and disrupts cell mechanosensitive signaling. Findings emphasize the critical role of PCM in fibrocartilage mechanobiology and suggest targeting it can enhance
Chao Wang +13 more
wiley +1 more source