Extracellular Matrix Molecules Facilitating Vascular Biointegration
All vascular implants, including stents, heart valves and graft materials exhibit suboptimal biocompatibility that significantly reduces their clinical efficacy.
Martin K.C. Ng +3 more
doaj +1 more source
Structural basis for the high-affinity interaction of nidogen-1 with immunoglobulin-like domain 3 of perlecan [PDF]
Marc Kvansakul
openalex +1 more source
Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-B
The immunoreceptor tyrosine-based inhibition motif (ITIM)-containing receptor G6b-B is critical for platelet production and activation. Loss of G6b-B results in severe macrothrombocytopenia, myelofibrosis and aberrant platelet function in mice and humans.
Timo Vögtle +27 more
doaj +1 more source
Heparan Sulfate in Perlecan Promotes Mouse Atherosclerosis [PDF]
Karin Tran‐Lundmark +9 more
openalex +1 more source
Perlecan is a component of cartilage matrix and promotes chondrocyte attachment [PDF]
Nirmala SundarRaj +4 more
openalex +1 more source
Perlecan Heparan Sulfate Proteoglycan [PDF]
Ilia V. Fuki +2 more
openaire +1 more source
Schwartz-Jampel syndrome (SJS) is a rare autosomal recessive disorder characterized by muscle stiffness (myotonia) and chondrodysplasia. This disease is caused by biallelic loss of function mutations in the HSPG2 gene, which encodes the core protein of ...
Iman Elahi Vahed +7 more
doaj +1 more source
Exogenous interferon-γ alters murine inner cell mass and trophoblast development. Effect on the expression of ErbB1, ErbB4 and heparan sulfate proteoglycan (perlecan) [PDF]
Vanina Andrea Fontana +5 more
openalex +1 more source
Perlecan: An Islet Basement Membrane Protein with Protective Anti-Inflammatory Characteristics
Throughout the isolation process, human islets are subjected to destruction of the islet basement membrane (BM) and reduced oxygen supply. Reconstruction of the BM represents an option to improve islet function and survival post-transplant and may ...
Daniel Brandhorst +3 more
doaj +1 more source
Perlecan, a heparan sulfate proteoglycan, regulates systemic metabolism with dynamic changes in adipose tissue and skeletal muscle [PDF]
Yuri Yamashita +7 more
openalex +1 more source

