Results 61 to 70 of about 1,195,562 (344)

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

Geological conditions for continental tight oil formation and the main controlling factors for the enrichment: A case of Chang 7 Member, Triassic Yanchang Formation, Ordos Basin, NW China

Petroleum Exploration and Development, 2017
The Chang7 Member of the Triassic Yanchang Formation in the Ordos Basin is a typical continental tight oil province. The geological conditions and the main controlling factors for the formation of tight oil province in Chang 7 Member were studied based ...
Hua YANG, Xiaowei LIANG, Xiaobing NIU, Shengbin FENG, Yuan YOU   +4 more
doaj   +1 more source

Effect of permeability enhancers on paracellular permeability of acyclovir

Journal of Pharmacy and Pharmacology, 2016
AbstractObjectivesAccording to Biopharmaceutics Classification System (BCS), acyclovir is a class III (high solubility, low permeability) compound, and it is transported through paracellular route by passive diffusion. The aim of this study was to investigate the effect of various pharmaceutical excipients on the intestinal permeability of acyclovir ...
Selma Sahin, Mustafa Sinan Kaynak, Muge Ates, Muge Ates   +3 more
openaire   +4 more sources

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source

A quantitative evaluation for well pattern adaptability in ultra-low permeability oil reservoirs: A case study of Triassic Chang 6 and Chang 8 reservoirs in Ordos Basin

Petroleum Exploration and Development, 2018
: Based on the previous studies and development practice in recent 10 years, a quantitative evaluation method for the adaptability of well patterns to ultra-low permeability reservoirs was established using cluster analysis and gray correlation method ...
Jiyong ZHAO, Xiaoping AN, Jing WANG, Jianming FAN, Xingmei KANG, Xiqun TAN, Wenqing LI   +6 more
doaj   +1 more source

Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation

Molecular Oncology, EarlyView.
Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides, Sara Cristobal‐Vargas, Cristina De Ramón, Elizabeta A. Rojas, Irena Misiewicz‐Krzeminska, Isabel Isidro, José Juan Pérez, Bruno Paiva, Noemi Puig, Miguel Alcoceba, María‐Victoria Mateos, Luis A. Corchete, Myriam Cuadrado, Norma C. Gutiérrez   +13 more
wiley   +1 more source

Porosity–Permeability Relations for Evolving Pore Space: A Review with a Focus on (Bio-)geochemically Altered Porous Media

Transport in Porous Media, 2018
Reactive transport processes in a porous medium will often both cause changes to the pore structure, via precipitation and dissolution of biomass or minerals, and be affected by these changes, via changes to the material’s porosity and permeability.
Johannes Hommel, E. Coltman, H. Class
semanticscholar   +1 more source

The tumor–microbe connection

Molecular Oncology, EarlyView.
Tumor‐associated bacteria (TAB) dynamically influence cancer biology by modulating tumor progression, metastatic spread, and therapeutic efficacy. Their presence redefines the tumor microenvironment (TME) as a microbial–host interface, yet mechanistic insights remain limited. Understanding TAB colonization routes, functional impacts, and crosstalk with
Gerlanda Vella, Maria Rescigno
wiley   +1 more source

Petroleum geological features and exploration prospect of Linhe Depression in Hetao Basin, China

Petroleum Exploration and Development, 2018
After over four decades of exploration, a major breakthrough has been made in the Hetao Basin recently, that is, commercial oil flow of 62.6 m3/d is tested from the Paleogene Linhe Formation in Well Song 5.
Suotang FU, Jinhua FU, Jian YU, Jingli YAO, Caili ZHANG, Zhanrong MA, Yajuan YANG, Yan ZHANG   +7 more
doaj   +1 more source

NOTIONAL PERMEABILITY [PDF]

Coastal Engineering Proceedings, 2012
Different layer design of a rock slope and under layers has a large effect on the strengths on the rock slope itself. In the stability formula developed of VAN DER MEER [1988] this effect is represented by the term Notional Permeability with symbol P.
Kik, R. (author), Van den Bos, J.P. (author), Maertens, J. (author), Verhagen, H.J. (author), Van der Meer, J.W. (author)   +4 more
openaire   +2 more sources