Results 41 to 50 of about 281,397 (261)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Flow Behavior Caused by Air Permeability of Ski Jumping Suit Fabric
Proceedings, 2020 The purpose of this study was to investigate the effect of the air permeability of ski jumping suit fabric on aerodynamic characteristics. In the study, four types of fabric with different air permeabilities were installed onto a fabric-clothed elliptic ...
Yuki Kataoka +4 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
A Multi-Scale Fractal Approach for Coal Permeability Estimation via MIP and NMR Methods
Energies, 2022 Permeability in porous media has an important role in many engineering applications, which depends mainly on the pore size, distribution, and connectivity of porous media.
Weiguang Ren +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Permeability characteristics of unsaturated fly ash and their impact on the stability of ash dam
Shuiwen dizhi gongcheng dizhiThe permeability characteristics of unsaturated fly ash play critical roles in the stability of ash dams under rainfall conditions. However, the mechanisms and effects of this influence remain incompletely understood. Using the Zhijin ash storage site in
Renjie LI, Bo WANG, Chengbo XU
doaj +1 more source
Seepage Characteristics of Slurry with Particle Additives in the High-Permeability Sand Layer
Geofluids, 2021 In the process of the slurry shield construction, the formation of the filter cake is the key to maintain the stability of the excavation face. In high-permeability formation, ordinary pure bentonite slurry is easy to pass through the formation void ...
Yuan Wang +5 more
doaj +1 more source
Study on coal permeability characteristics under thermo-mechanical coupling
Meikuang Anquan, 2022 The increase of coal mining depth leads to the increase of ground temperature and stress, which affects the development of fractures and seepage characteristics.
YI Xin +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source