Results 31 to 40 of about 97,236 (263)

Regulation of Permeation in Aquaporins [PDF]

, 2022
Regulation of water permeation is an essential aspect of homeostasis in living organisms. Proteins of the ubiquitous aquaporin family act as trans-membrane tetrameric channels through which water may permeate under osmotic gradients in a bidirectional manner.
Kaptan, Shreyas Sanjay, Groot, Bert De, Groot, Bert De, Georg-August-Universität Göttingen, Mueller, Marcus, Bennati, Marina   +5 more
openaire   +3 more sources

Lanolin-Based Synthetic Membranes for Transdermal Permeation and Penetration Drug Delivery Assays

Membranes, 2021
Due to the high similarity in composition and structure between lanolin and human SC lipids, we will work with two models from wool wax. Two types of lanolin were evaluated: one extracted with water and surfactants (WEL) and the other extracted with ...
Cristina Alonso, Ilaria Collini, Meritxell Martí, Clara Barba, Luisa Coderch   +4 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Delivery of amphotericin B for effective treatment of Candida albicans induced dermal mycosis in rats via emulgel system: Formulation and evaluation

Indian Journal of Dermatology, 2014
Background: Amphotericin B (AmB) is among the gold standard antifungal agents used for the treatment of the wide range of fungal infections. However, the drug has various side- effects. Transdermal approach for the delivery of drug is one of the accepted
Aditya Ganeshpurkar, Pooja Vaishya, Sumeet Jain, Vikas Pandey, Divya Bansal, Nazneen Dubey   +5 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Nanoemulsions as a Promising Carrier for Topical Delivery of Etodolac: Formulation Development and Characterization

Pharmaceutics, 2023
This research primarily focuses on the development of innovative topical nanoemulsions for etodolac, aimed at surmounting its inherent limitations.
Samet Özdemir, Burcu Üner, Alptuğ Karaküçük, Burak Çelik, Engin Sümer, Çetin Taş   +5 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Molecular Dynamics Investigation of the Effect of Shear during Extrusion on the Permeation Behavior of CH₄ in High-Density Polyethylene

Journal of Marine Science and Engineering, 2023
Deep-water flexible composite pipes have been widely employed in the domain of deep-water oil and gas transportation, and high-density polyethylene (HDPE) is used to seal the inner sheath of internal oil and gas media containing H2S and CH4, due to its ...
Hongxia Li, Tianyang Yang, Xuewen Guo, Yupeng Wu, Jun Yan, Qingzhen Lu   +5 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Investigating the Potential of Phosphatidylcholine-Based Nano-Sized Carriers in Boosting the Oto-Topical Delivery of Caroverine: in vitro Characterization, Stability Assessment and ex vivo Transport Studies

International Journal of Nanomedicine, 2020
Amira Yousry Farrah,1 Abdulaziz M Al-mahallawi,2,3 Emad B Basalious,2 Demiana I Nesseem1 1Department of Pharmaceutics, National Organization for Drug Control and Research, Cairo, Egypt; 2Department of Pharmaceutics and Industrial Pharmacy, Faculty of ...
Farrah AY, Al-mahallawi AM, Basalious EB, Nesseem DI   +3 more
doaj