Results 41 to 50 of about 140,106 (238)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

DnaC inactivation in Escherichia coli K-12 induces the SOS response and expression of nucleotide biosynthesis genes.

PLoS ONE, 2008
BackgroundInitiation of chromosome replication in E. coli requires the DnaA and DnaC proteins and conditionally-lethal dnaA and dnaC mutants are often used to synchronize cell populations.Methodology/principal findingsDNA microarrays were used to measure
Anders Løbner-Olesen, Monika Slominska-Wojewodzka, Flemming G Hansen, Martin G Marinus   +3 more
doaj   +1 more source

Permissive Controller Synthesis for Probabilistic Systems [PDF]

Logical Methods in Computer Science, 2015
We propose novel controller synthesis techniques for probabilistic systems modelled using stochastic two-player games: one player acts as a controller, the second represents its environment, and probability is used to capture uncertainty arising due to ...
Klaus Drager, Vojtech Forejt, Marta Kwiatkowska, David Parker, Mateusz Ujma   +4 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Pedestrian safety under permissive left-turn signal control

International Journal of Transportation Science and Technology, 2017
At intersections with permissive only signal control, pedestrians will move at the phase with the parallel through vehicular movement and the permissive left-turn movement. The left-turn vehicles have to yield to both opposing vehicles and pedestrians at
Yi Qi, Aohan Guoguo
doaj   +1 more source

Extensive transcription analysis of the Hyposoter didymator Ichnovirus genome in permissive and non-permissive lepidopteran host species. [PDF]

PLoS ONE, 2014
Ichnoviruses are large dsDNA viruses that belong to the Polydnaviridae family. They are specifically associated with endoparasitic wasps of the family Ichneumonidae and essential for host parasitization by these wasps.
Tristan Dorémus, François Cousserans, Gabor Gyapay, Véronique Jouan, Patricia Milano, Eric Wajnberg, Isabelle Darboux, Fernando Luis Cônsoli, Anne-Nathalie Volkoff   +8 more
doaj   +1 more source

The Human Leukocyte Antigen-DPB1 Degree of Compatibility Is Determined by Its Expression Level and Mismatch Permissiveness: A German Multicenter Analysis

Frontiers in Immunology, 2021
T-cell epitope matching according to the TCE3 algorithm classifies HLA-DPB1 mismatches in permissive and non-permissive. This classification has been shown to be predictive for mortality and acute GvHD (aGvHD) events in large international cohorts.
Daphne Mytilineos, Daphne Mytilineos, Daphne Mytilineos, Chrysanthi Tsamadou, Chrysanthi Tsamadou, Christine Neuchel, Christine Neuchel, Uwe Platzbecker, Donald Bunjes, Natalie Schub, Eva Wagner-Drouet, Gerald Wulf, Nicolaus Kröger, Niels Murawski, Hermann Einsele, Kerstin Schaefer-Eckart, Sebastian Freitag, Jochen Casper, Martin Kaufmann, Mareike Dürholt, Bernd Hertenstein, Stefan Klein, Mark Ringhoffer, Carlheinz R. Mueller, Carlheinz R. Mueller, Sandra Frank, Hubert Schrezenmeier, Hubert Schrezenmeier, Daniel Fuerst, Daniel Fuerst, Joannis Mytilineos, Joannis Mytilineos, Joannis Mytilineos   +32 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

New capsaicin analogs as molecular rulers to define the permissive conformation of the mouse TRPV1 ligand-binding pocket

eLife, 2020
The capsaicin receptor TRPV1 is an outstanding representative of ligand-gated ion channels in ligand selectivity and sensitivity. However, molecular interactions that stabilize the ligand-binding pocket in its permissive conformation, and how many ...
Simon Vu, Vikrant Singh, Heike Wulff, Vladimir Yarov-Yarovoy, Jie Zheng   +4 more
doaj   +1 more source