Results 91 to 100 of about 1,103,558 (313)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

A direct cerebello-telencephalic projection in an electrosensory mormyrid fish [PDF]

, 1990
After injections of the posterior part of the lateral zone of the area dorsalis telencephali (Dlp) with either horseradish peroxidase or the newly available carbocyanine dye DiI, efferent cells were labeled in the valvula cerebelli of the mormyrid fish ...
Ebbesson, Echteler, Erdl, Finger, Finger, Finger, Godement, Hanker, Lissman, Meek, Murakami, Murakami, Nieuwenhuys, Nieuwenhuys, Nieuwenhuys, Northcutt, Rooney, Russell, Szabo, Weston, Wullimann, Wullimann, Wullimann   +22 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Zinc improves salt tolerance by increasing reactive oxygen species scavenging and reducing Na+ accumulation in wheat seedlings

Biologia Plantarum, 2014
Salt decreases the uptake of Zn and other minerals and causes nutritional disorders in plants. Zn is an essential micronutrient for all organisms and it is reasonable to hypothesize that Zn status is essential for maintaining salt tolerance in plants. In
L. H. Xu, W. Y. Wang, J. J. Guo, J. Qin, D. Q. Shi, Y. L. Li, J. Xu   +6 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Calcium-Dependent Chemiluminescence Catalyzed by a Truncated c-MYC Promoter G-Triplex DNA

Molecules
The dynamic landscape of non-canonical DNA G-quadruplex (G4) folding into G-triplex intermediates has led to the study of G-triplex structures and their ability to serve as peroxidase-mimetic DNAzymes.
Malay Kumar Das, Elizabeth P. Williams, Mitchell W. Myhre, Wendi M. David, Sean M. Kerwin   +4 more
doaj   +1 more source

Comparison of antioxidant responses to cadmium and lead in Bruguiera gymnorrhiza seedlings

Biologia Plantarum, 2012
Seedlings of mangrove plant Bruguiera gymnorrhiza cultured in sand with Hoagland's nutrient solution were treated with 1 to 30 mM Cd(NO3)2 or Pb(NO3)2 for 2 months.
Y. M. Tao, Y. Z. Chen, T. Tan, X. C. Liu, D. L. Yang, S. C. Liang   +5 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

The effect of exogenously applied nitric oxide on photosynthesis and antioxidant activity in heat stressed chrysanthemum

Biologia Plantarum, 2011
The effect of exogenously applied nitric oxide on the heat tolerance of Chrysanthemum morifolium was investigated by applying the NO donor sodium nitroprusside (SNP).
W. Yang, Y. Sun, S. Chen, J. Jiang, F. Chen, W. Fang, Z. Liu   +6 more
doaj   +1 more source

Selected reactive oxygen species and antioxidant enzymes in common bean after Pseudomonas syringae pv. phaseolicola and Botrytis cinerea infection [PDF]

, 2014
Phaseolus vulgaris cv. Korona plants were inoculated with the bacteria Pseudomonas syringae pv. phaseolicola (Psp), necrotrophic fungus Botrytis cinerea (Bc) or with both pathogens sequentially.
A Encina, A Imberty, A Koornneef, A Mika, A Polle, A Sakamoto, A Schouten, AC Maehly, Agata Nowogórska, AM Mayer, B Williamson, BA Adie, BPHJ Thomma, C Beauchamp, C Bowler, C Lamb, DG Mellersh, DJ Capaldi, F Garcia-Arenal, F Passardi, G Creissen, G Oudgenoeg, GJM Beckers, H Derksen, H Thordal-Christensen, HH Flor, I Finiti, J Glazebrook, J Patykowski, J Shi, Jacek Patykowski, JR Alfano, JS Thaler, K Laluk, KG Welinder, M Sedlářová, MC Mehdy, MC Romero-Puertas, MM Bradford, N Doke, N Shlezinger, P Baarlen Van, P Baptista, P Wojtaszek, PP Bolwell, R Goldberg, R Huckelhoven, R Schwacke, RS Dhindsa, S AbuQamar, S AbuQamar, S Dorey, S Takahashi, SJ Burr, T Mengiste, U Takahama, UK Laemmli   +56 more
core   +2 more sources