Results 91 to 100 of about 1,115,092 (313)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Zinc improves salt tolerance by increasing reactive oxygen species scavenging and reducing Na+ accumulation in wheat seedlings

Biologia Plantarum, 2014
Salt decreases the uptake of Zn and other minerals and causes nutritional disorders in plants. Zn is an essential micronutrient for all organisms and it is reasonable to hypothesize that Zn status is essential for maintaining salt tolerance in plants. In
L. H. Xu, W. Y. Wang, J. J. Guo, J. Qin, D. Q. Shi, Y. L. Li, J. Xu   +6 more
doaj   +1 more source

????????? ?????????????????? ????????? ????????? ?????? ??????????????? ??????????????? ?????? ???????????? ?????? [PDF]

, 2020
Department of Chemical EngineeringLignin peroxidase is promising ingredient for skin whitening cosmetics because it is capable of oxidizing melanin with high redox potential.
Sung, Ho Joon
core  

TcI isolates of Trypanosoma cruzi exploit the antioxidant network for enhanced intracellular survival in macrophages and virulence in mice [PDF]

, 2016
Trypanosoma cruzi species is categorized into six discrete typing units (TcI to TcVI) of which TcI is most abundantly noted in the sylvatic transmission cycle and considered the major cause of human disease. In our study, the TcI strains Colombiana (COL),
Basombrío, Miguel Ángel Manuel, Dhiman, Monisha, Garg, Nisha J., Hosakote, Yashoda M., Koo, Sue Jie, Parodi­ Talice, Adriana, Piñeyro, María Dolores, Robello, Carlos, Zago, María Paola   +8 more
core   +3 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Calcium-Dependent Chemiluminescence Catalyzed by a Truncated c-MYC Promoter G-Triplex DNA

Molecules
The dynamic landscape of non-canonical DNA G-quadruplex (G4) folding into G-triplex intermediates has led to the study of G-triplex structures and their ability to serve as peroxidase-mimetic DNAzymes.
Malay Kumar Das, Elizabeth P. Williams, Mitchell W. Myhre, Wendi M. David, Sean M. Kerwin   +4 more
doaj   +1 more source

Comparison of antioxidant responses to cadmium and lead in Bruguiera gymnorrhiza seedlings

Biologia Plantarum, 2012
Seedlings of mangrove plant Bruguiera gymnorrhiza cultured in sand with Hoagland's nutrient solution were treated with 1 to 30 mM Cd(NO3)2 or Pb(NO3)2 for 2 months.
Y. M. Tao, Y. Z. Chen, T. Tan, X. C. Liu, D. L. Yang, S. C. Liang   +5 more
doaj   +1 more source

Immunostaining of skeletal tissues [PDF]

, 2011
Peer ...
De Bari, Cosimo, Kurth, Tobias B
core   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

The effect of exogenously applied nitric oxide on photosynthesis and antioxidant activity in heat stressed chrysanthemum

Biologia Plantarum, 2011
The effect of exogenously applied nitric oxide on the heat tolerance of Chrysanthemum morifolium was investigated by applying the NO donor sodium nitroprusside (SNP).
W. Yang, Y. Sun, S. Chen, J. Jiang, F. Chen, W. Fang, Z. Liu   +6 more
doaj   +1 more source