Results 101 to 110 of about 1,072,450 (362)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Calcium-Dependent Chemiluminescence Catalyzed by a Truncated c-MYC Promoter G-Triplex DNA

Molecules
The dynamic landscape of non-canonical DNA G-quadruplex (G4) folding into G-triplex intermediates has led to the study of G-triplex structures and their ability to serve as peroxidase-mimetic DNAzymes.
Malay Kumar Das, Elizabeth P. Williams, Mitchell W. Myhre, Wendi M. David, Sean M. Kerwin   +4 more
doaj   +1 more source

Comparison of antioxidant responses to cadmium and lead in Bruguiera gymnorrhiza seedlings

Biologia Plantarum, 2012
Seedlings of mangrove plant Bruguiera gymnorrhiza cultured in sand with Hoagland's nutrient solution were treated with 1 to 30 mM Cd(NO3)2 or Pb(NO3)2 for 2 months.
Y. M. Tao, Y. Z. Chen, T. Tan, X. C. Liu, D. L. Yang, S. C. Liang   +5 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Serum selenium levels and blood glutathione peroxidase activities in vitiligo

, 2001
It has recently been shown that patients with vitiligo can accumulate epidermal hydrogen peroxide (H2O2) in association with low catalase levels. This study examined serum selenium levels and blood glutathione peroxidase activities in 61 patients and ...
Schallreuter, K.U., Beazley, W.D., Gaze, D.C., Panske, A., Panzig, E.   +4 more
core   +1 more source

The effect of exogenously applied nitric oxide on photosynthesis and antioxidant activity in heat stressed chrysanthemum

Biologia Plantarum, 2011
The effect of exogenously applied nitric oxide on the heat tolerance of Chrysanthemum morifolium was investigated by applying the NO donor sodium nitroprusside (SNP).
W. Yang, Y. Sun, S. Chen, J. Jiang, F. Chen, W. Fang, Z. Liu   +6 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

The effect of the duration of hypoxia on the activity of peroxidase, superoxide dismutase and catalase in the roots of clonal Eucalyptus marginata [PDF]

, 1997
Roots of E. marginata exposed to hypoxia show increased resistance to infection by P. cinnamomi. A plant defence enzyme, peroxidase (PO), involved in lignin and suberin synthesis, the clearance of hydrogen peroxide and the cross-linking of cell wall ...
Hardy, G.E.St.J., McComb, J.A., Burgess, T.   +2 more
core  

Peroxidase-like Active Nanomedicine with Dual Glutathione Depletion Property to Restore Oxaliplatin Chemosensitivity and Promote Programmed Cell Death

, 2022
The nanocatalytic activity of nanozymes provides a vision for tumor treatment. However, the glutathione (GSH)-related antioxidant defense system (ADS) formed on the basis of excessive GSH in the tumor microenvironment limits its catalytic activity. Here,
Jiani Yang, Fei He, Boyang Shao, Yuanfei Yao, Feng Wu (12185), Fei He (145896), Ying Cui, Yanqiao Zhang (109157), Yaqian Du (12224481), Boyang Shao (9745354), Zhensheng Mi (12224484), Feng Wu, Zhensheng Mi, Ying Cui (93661), Piaoping Yang, Jiani Yang (5740595), Yuanfei Yao (449895), Yaqian Du, Yanqiao Zhang, Piaoping Yang (1467661)   +19 more
core   +1 more source

The Rpv3-3 Haplotype and Stilbenoid Induction Mediate Downy Mildew Resistance in a Grapevine Interspecific Population

Frontiers in Plant Science, 2019
The development of new resistant varieties to the oomycete Plasmopara viticola (Berk.& Curt) is a promising way to combat downy mildew (DM), one of the major diseases threatening the cultivated grapevine (Vitis vinifera L.).
Silvia Vezzulli, Giulia Malacarne, Domenico Masuero, Antonella Vecchione, Chiara Dolzani, Vadim Goremykin, Zeraye Haile Mehari, Zeraye Haile Mehari, Elisa Banchi, Elisa Banchi, Riccardo Velasco, Riccardo Velasco, Marco Stefanini, Urska Vrhovsek, Luca Zulini, Pietro Franceschi, Claudio Moser   +16 more
doaj   +1 more source