Results 61 to 70 of about 458,211 (297)

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Optimizing an Injectable Composite Oxygen-Generating System for Relieving Tissue Hypoxia

Frontiers in Bioengineering and Biotechnology, 2020
Oxygen deficiency resulting from bone fracture-induced vascular disruption leads to massive cell death and delayed osteoblast differentiation, ultimately impairing new bone formation and fracture healing.
Tai-En Hsieh, Sheng-Ju Lin, Li-Chi Chen, Li-Chi Chen, Chun-Chieh Chen, Chun-Chieh Chen, Po-Liang Lai, Po-Liang Lai, Chieh-Cheng Huang   +8 more
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Phenological cycle and physicochemical characteristics of avocado cultivars in subtropical conditions

AIMS Energy, 2017
Avocado has a great potential as a commercial crop in southern Brazil, for its high productivity, rusticity, and multiple uses. Its high oil content can be explored for biodiesel production with advantages over other crops.
Geovanna Cristina Zaro, Paulo Henrique Caramori, Cíntia Sorane Good Kitzberger, Fernanda Aparecida Sales, Sergio Luiz Colucci de Carvalho, Cássio Egidio Cavenaghi Prete   +5 more
doaj   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Efeito do cozimento por extrusão na estabilidade oxidativa de produtos de moagem de aveia Extrusion cooking effects on oxidative stability of oat coarse milling product

Pesquisa Agropecuária Brasileira, 1999
O objetivo do presente trabalho foi estudar os efeitos de umidade e de temperatura de extrusão na estabilidade oxidativa de produtos de aveia (Avena sativa L.).
Luiz Carlos Gutkoski, Ahmed Attia El-Dash   +1 more
doaj   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

Foliar Application of Selenium Enhances Drought Tolerance in Tomatoes by Modulating the Antioxidative System and Restoring Photosynthesis

Agronomy
Drought stress can impact the physiological and biochemical properties of crops. However, selenium (Se) can effectively alleviate the abiotic stress experienced by plants.
Yuan Zhong, Haixue Cui, Huanhuan Li, Xiaoman Qiang, Qisheng Han, Hao Liu   +5 more
doaj   +1 more source