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The Hansenula polymorpha PER8 Gene Encodes a Novel Peroxisomal Integral Membrane Protein Involved in Proliferation [PDF]

, 1995
We previously described the isolation of mutants of the methylotrophic yeast Hansenula polymorpha that are defective in peroxisome biogenesis. Here, we describe the characterization of one of these mutants, per8, and the cloning of the PER8 gene.
Cregg, James M.,, Tan, Xuqiu,, Veenhuis, Marten,, Waterham, Hans R.,   +3 more
core   +10 more sources

The Peroxisome-Autophagy Redox Connection: A Double-Edged Sword?

Frontiers in Cell and Developmental Biology, 2021
Peroxisomes harbor numerous enzymes that can produce or degrade hydrogen peroxide (H2O2). Depending on its local concentration and environment, this oxidant can function as a redox signaling molecule or cause stochastic oxidative damage. Currently, it is
Hongli Li, Celien Lismont, Iulia Revenco, Mohamed A. F. Hussein, Mohamed A. F. Hussein, Cláudio F. Costa, Marc Fransen   +6 more
doaj   +1 more source

Enhanced Levels of Peroxisome-Derived H₂O₂ Do Not Induce Pexophagy but Impair Autophagic Flux in HEK-293 and HeLa Cells

Antioxidants, 2023
Peroxisomes are functionally specialized organelles that harbor multiple hydrogen peroxide (H2O2)-producing and -degrading enzymes. Given that this oxidant functions as a major redox signaling agent, peroxisomes have the intrinsic ability to mediate and ...
Hongli Li, Celien Lismont, Cláudio F. Costa, Mohamed A. F. Hussein, Myriam Baes, Marc Fransen   +5 more
doaj   +1 more source

Peroxisome-Derived Hydrogen Peroxide Modulates the Sulfenylation Profiles of Key Redox Signaling Proteins in Flp-In T-REx 293 Cells

Frontiers in Cell and Developmental Biology, 2022
The involvement of peroxisomes in cellular hydrogen peroxide (H2O2) metabolism has been a central theme since their first biochemical characterization by Christian de Duve in 1965.
Celien Lismont, Iulia Revenco, Hongli Li, Cláudio F. Costa, Lisa Lenaerts, Mohamed A. F. Hussein, Jonas De Bie, Bernard Knoops, Paul P. Van Veldhoven, Rita Derua, Rita Derua, Marc Fransen   +11 more
doaj   +1 more source

Oxiapoptophagy in Age-Related Diseases. Comment on Ouyang et al. 7-Ketocholesterol Induces Oxiapoptophagy and Inhibits Osteogenic Differentiation in MC3T3-E1 Cells. Cells 2022, 11, 2882

Cells, 2022
Due to the increase in life span and life expectancy, which can, however, be more or less pronounced depending on the economic, social and cultural context [...]
Imen Ghzaiel, Thomas Nury, Amira Zarrouk, Anne Vejux, Gérard Lizard   +4 more
doaj   +1 more source

Functional Analysis of GSTK1 in Peroxisomal Redox Homeostasis in HEK-293 Cells

Antioxidants, 2023
Peroxisomes serve as important centers for cellular redox metabolism and communication. However, fundamental gaps remain in our understanding of how the peroxisomal redox equilibrium is maintained.
Cláudio F. Costa, Celien Lismont, Serhii Chornyi, Hongli Li, Mohamed A. F. Hussein, Hans R. Waterham, Marc Fransen   +6 more
doaj   +1 more source

Characterization of Cell Death Induced by Imine Analogs of Trans-Resveratrol: Induction of Mitochondrial Dysfunction and Overproduction of Reactive Oxygen Species Leading to, or Not, Apoptosis without the Increase in the S-Phase of the Cell Cycle

Molecules, 2023
Trans-resveratrol (RSV) is a non-flavonoid polyphenol (stilbene) with numerous biological activities, such as anti-tumor activities. However, RSV is rapidly metabolized, which limits its therapeutic use.
Mohamed Ksila, Imen Ghzaiel, Vivien Pires, Taoufik Ghrairi, Olfa Masmoudi-Kouki, Norbert Latruffe, Dominique Vervandier-Fasseur, Anne Vejux, Gérard Lizard   +8 more
doaj   +1 more source

Polyphenols of the Mediterranean Diet and Their Metabolites in the Prevention of Colorectal Cancer

Molecules, 2021
The Mediterranean diet is a central element of a healthy lifestyle, where polyphenols play a key role due to their anti-oxidant properties, and for some of them, as nutripharmacological compounds capable of preventing a number of diseases, including ...
Aline Yammine, Amira Namsi, Dominique Vervandier-Fasseur, John J. Mackrill, Gérard Lizard, Norbert Latruffe   +5 more
doaj   +1 more source

Cytotoxic and Antioxidant Activities of Imine Analogs of Trans-Resveratrol towards Murine Neuronal N2a Cells

Molecules, 2022
Trans-resveratrol is a natural polyphenol showing numerous biological properties, especially anti-tumoral and antioxidant activity. Among numerous resveratrol derivatives, aza-stilbenes, which bear an imine bound, show interesting biological activities ...
Mohamed Ksila, Anne Vejux, Emmanuelle Prost-Camus, Philippe Durand, Imen Ghzaiel, Thomas Nury, Dorian Duprey, Smail Meziane, Olfa Masmoudi-Kouki, Norbert Latruffe, Taoufik Ghrairi, Michel Prost, Gérard Lizard, Dominique Vervandier-Fasseur   +13 more
doaj   +1 more source

A Pex7 Deficient Mouse Series Correlates Biochemical and Neurobehavioral Markers to Genotype Severity—Implications for the Disease Spectrum of Rhizomelic Chondrodysplasia Punctata Type 1

Frontiers in Cell and Developmental Biology, 2022
Rhizomelic chondrodysplasia punctata type 1 (RCDP1) is a peroxisome biogenesis disorder caused by defects in PEX7 leading to impairment in plasmalogen (Pls) biosynthesis and phytanic acid (PA) oxidation.
Wedad Fallatah, Wedad Fallatah, Wei Cui, Erminia Di Pietro, Grace T. Carter, Brittany Pounder, Fabian Dorninger, Christian Pifl, Ann B. Moser, Johannes Berger, Nancy E. Braverman, Nancy E. Braverman   +11 more
doaj   +1 more source