Results 11 to 20 of about 153,107 (266)
Biochimie, 2014 Peroxisomes are essential organelles in higher eukaryotes as they play a major role in numerous metabolic pathways and redox homeostasis. Some peroxisomal abnormalities, which are often not compatible with life or normal development, were identified in severe demyelinating and neurodegenerative brain diseases.
Trompier, Doriane +7 more
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Diseases, 2018 In the prevention of neurodegeneration associated with aging and neurodegenerative diseases (Alzheimer’s disease, Parkinson’s disease), neuronal differentiation is of interest.
Amira Namsi +8 more
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Aza- and Azo-Stilbenes: Bio-Isosteric Analogs of Resveratrol
Molecules, 2020 Several series of natural polyphenols are described for their biological and therapeutic potential. Natural stilbenoid polyphenols, such as trans-resveratrol, pterostilbene and piceatannol are well-known for their numerous biological activities. However,
Gérard Lizard +2 more
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A Model of Lipid Monolayer–Bilayer Fusion of Lipid Droplets and Peroxisomes
Membranes, 2022 Lipid droplets are unique organelles that store neutral lipids encapsulated by the lipid monolayer. In some processes of cellular metabolism, lipid droplets interact with peroxisomes resulting in the fusion of their envelopes and the formation of ...
Maksim A. Kalutsky +2 more
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Molecules, 2020 The brain, which is a cholesterol-rich organ, can be subject to oxidative stress in a variety of pathophysiological conditions, age-related diseases and some rare pathologies.
Aline Yammine +8 more
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Edgetic Perturbations Contribute to Phenotypic Variability in PEX26 Deficiency
Frontiers in Genetics, 2021 Peroxisomes share metabolic pathways with other organelles and peroxisomes are embedded into key cellular processes. However, the specific function of many peroxisomal proteins remains unclear and restricted knowledge of the peroxisomal protein ...
Amelie S. Lotz-Havla +7 more
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Peroxisome Synthesis in the Absence of Preexisting Peroxisomes [PDF]
The Journal of Cell Biology, 1999 Zellweger syndrome and related diseases are caused by defective import of peroxisomal matrix proteins. In all previously reported Zellweger syndrome cell lines the defect could be assigned to the matrix protein import pathway since peroxisome membranes were present, and import of integral peroxisomal membrane proteins was normal.
S T, South, S J, Gould
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Frontiers in Cell and Developmental Biology, 2022 Peroxisomes are eukaryotic specific organelles that perform diverse metabolic functions including fatty acid β-oxidation, reactive species metabolism, photorespiration, and responses to stress. However, the potential regulation of these functions by post-
Amr Kataya +8 more
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Peroxisomes: Organelles at the crossroads [PDF]
Trends in Cell Biology, 1997 Recent years have seen remarkable progress in our understanding of the function of peroxisomes in higher and lower eukaryotes. Combined genetic and biochemical approaches have led to the identification of many genes required for the biogenesis of this organelle.
Erdmann, R +3 more
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Frontiers in Molecular Neuroscience, 2018 Amyotrophic lateral sclerosis (ALS) is a non-demyelinating neurodegenerative disease in adults with motor disorders. Two forms exist: a sporadic form (90% of cases) and a family form due to mutations in more than 20 genes including the Superoxide ...
Anne Vejux +6 more
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