Results 11 to 20 of about 188,367 (306)
Peroxisome-mitochondria interplay and disease
, 2015 Peroxisomes and mitochondria are ubiquitous, highly dynamic organelles with an oxidative type of metabolism in eukaryotic cells. Over the years, substantial evidence has been provided that peroxisomes and mitochondria exhibit a close functional interplay
J Costello (11103897) +3 more
core +6 more sources
USP30-Mediated Deubiquitination of PEX5 Suppresses Pexophagy to Drive Tubular Injury in Diabetic Kidney Disease. [PDF]
Adv Sci (Weinh)USP30 accumulation in diabetic renal tubular epithelial cells deubiquitinates PEX5, suppresses pexophagy, and drives dysfunctional peroxisome accumulation and tubular injury. USP30 depletion restores PEX5 ubiquitination and pexophagy, improves peroxisomal function, and alleviates tubular damage, highlighting USP30 as a therapeutic target in diabetic ...
Li J +10 more
europepmc +2 more sources
Biochimie, 2014 Peroxisomes are essential organelles in higher eukaryotes as they play a major role in numerous metabolic pathways and redox homeostasis. Some peroxisomal abnormalities, which are often not compatible with life or normal development, were identified in severe demyelinating and neurodegenerative brain diseases.
Trompier, Doriane +7 more
openaire +4 more sources
Peroxisome Proliferator-Activated Receptor Alpha Target Genes [PDF]
, 2010 The peroxisome proliferator-activated receptor alpha (PPARα) is a ligand-activated transcription factor involved in the regulation of a variety of processes, ranging from inflammation and immunity to nutrient metabolism and energy homeostasis.
Rakhshandehroo, M. +11 more
core +1 more source
Peroxisome Proliferator Activated Receptors and Lipoprotein Metabolism [PDF]
, 2008 Plasma lipoproteins are responsible for carrying triglycerides and cholesterol in the blood and ensuring their delivery to target organs. Regulation of lipoprotein metabolism takes place at numerous levels including via changes in gene transcription.
Kersten, A.H., Sander Kersten
core +1 more source
Activation of peroxisome proliferator-activated receptor alpha in human peripheral blood mononuclear cells reveals an individual gene expression profile response [PDF]
, 2007 Peripheral blood mononuclear cells (PBMCs) are relatively easily obtainable cells in humans. Gene expression profiles of PBMCs have been shown to reflect the pathological and physiological state of a person.
Afman, Lydia A. +13 more
core +1 more source
Molecules, 2020 The brain, which is a cholesterol-rich organ, can be subject to oxidative stress in a variety of pathophysiological conditions, age-related diseases and some rare pathologies.
Aline Yammine +8 more
doaj +1 more source
A Model of Lipid Monolayer–Bilayer Fusion of Lipid Droplets and Peroxisomes
Membranes, 2022 Lipid droplets are unique organelles that store neutral lipids encapsulated by the lipid monolayer. In some processes of cellular metabolism, lipid droplets interact with peroxisomes resulting in the fusion of their envelopes and the formation of ...
Maksim A. Kalutsky +2 more
doaj +1 more source
Aza- and Azo-Stilbenes: Bio-Isosteric Analogs of Resveratrol
Molecules, 2020 Several series of natural polyphenols are described for their biological and therapeutic potential. Natural stilbenoid polyphenols, such as trans-resveratrol, pterostilbene and piceatannol are well-known for their numerous biological activities. However,
Gérard Lizard +2 more
doaj +1 more source
Edgetic Perturbations Contribute to Phenotypic Variability in PEX26 Deficiency
Frontiers in Genetics, 2021 Peroxisomes share metabolic pathways with other organelles and peroxisomes are embedded into key cellular processes. However, the specific function of many peroxisomal proteins remains unclear and restricted knowledge of the peroxisomal protein ...
Amelie S. Lotz-Havla +7 more
doaj +1 more source