Results 31 to 40 of about 261,210 (338)
Neurophysiological, behavioral and morphological abnormalities in the Fabry knockout mice
Neurobiology of Disease, 2009 Fabry disease (OMIM 301500) is a rare X-linked recessive disorder caused by mutations in the α-galactosidase gene (GLA). Loss of α-galactosidase (α-Gal) activity leads to the abnormal accumulation of glycosphingolipids in lysosomes predominantly of ...
L.G. Rodrigues +7 more
doaj +1 more source
PPAR gamma pro12Ala polymorphism and type 2 diabetes: a study in a spanish cohort [PDF]
, 2014 Type 2 diabetes (T2D) is a disease whose occurrence is increasing prevalent in westernized civilizations and is responsible for the proliferation in the morbidity and total mortality of patients with cardiovascular diseases, worldwide.
Cieza Borrella, C +5 more
core +1 more source
Frontiers in Physiology, 2021 Carnitine palmitoyltransferase II (CPTII) deficiency is the most frequent inherited disorder regarding muscle fatty acid metabolism, resulting in a reduced mitochondrial long-chain fatty acid oxidation during endurance exercise. This condition leads to a
Massimo Negro +9 more
doaj +1 more source
A role for peroxisome proliferator-activated receptors in the immunopathology of schistosomiasis? [PDF]
, 2012 Peroxisome proliferator-activated receptors (PPARs) have been demonstrated to have a role in immune regulation. In general, they are anti-inflammatory and promote Th2 type responses, and they are associated with the alternative activation of macrophages.
Allen, JT +3 more
core +4 more sources
PPM1A Controls Diabetic Gene Programming through Directly Dephosphorylating PPAR?? at Ser273 [PDF]
, 2020 Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a master regulator of adipose tissue biology. In obesity, phosphorylation of PPAR gamma at Ser273 (pSer273) by cyclin-dependent kinase 5 (CDK5)/extracellular signal-regulated kinase (ERK ...
Choi, Jang Hyun +11 more
core +1 more source
Variants of the human PPARG locus and the susceptibility to chronic periodontitis [PDF]
, 2011 Apart from its regulatory function in lipid and glucose metabolism, peroxisome proliferator-activated receptor (PPAR)γ has impact on the regulation of inflammation and bone metabolism.
Desvergne B +5 more
core +1 more source
Annals of Medicine, 1992 The peroxisomal diseases, which are rare inborn metabolic errors, often have serious effects on the well being of the individual and many of them are fatal at an early age. The Zellweger cerebro-hepato-renal syndrome represents a group consisting of diseases with a generalized loss of peroxisomal functions and is considered as a prototype for ...
P M, Palosaari +2 more
openaire +2 more sources
Cytoprotective and Antioxidants in Peroxisomal Neurodegenerative Diseases
Proceedings, 2019 Several of the peroxisomal neurodegenerative disorders are the consequence of a specific deficiency of an enzyme or a transporter involved in peroxisomal beta-oxidation of very long chain fatty acids [1,2].
Mustapha Cherkaoui-Malki +9 more
doaj +1 more source
ISOC1 Modulates Inflammatory Responses in Macrophages through the AKT1/PEX11B/Peroxisome Pathway
Molecules, 2022 Inflammation underlies a variety of physiological and pathological processes and plays an essential role in shaping the ensuing adaptive immune responses and in the control of pathogens.
Xiaoyuan Lin +6 more
doaj +1 more source
Characterization of the Peroxisomal Proteome and Redox Balance in Human Prostate Cancer Cell Lines
AntioxidantsProstate cancer (PCa) is associated with disruptions in cellular redox balance. Given the intricate role of peroxisomes in redox metabolism, we conducted comprehensive proteomics analyses to compare peroxisomal and redox protein profiles between benign ...
Mohamed A. F. Hussein +5 more
doaj +1 more source