Results 1 to 10 of about 190,211 (348)

Chondrosarcoma and Peroxisome Proliferator-Activated Receptor [PDF]

PPAR Research, 2008
Induction of differentiation and apoptosis in cancer cells by ligands of PPARγ is a novel therapeutic approach to malignant tumors. Chondrosarcoma (malignant cartilage tumor) and OUMS‐27 cells (cell line established from grade III human chondrosarcoma) express PPARγ.
K. Hashizume, T. Ozaki, Y. Kadota, Z. N. Shen, T. Kunisada, K. Nishida   +5 more
doaj   +3 more sources

Peroxisome proliferator–activated receptor delta and liver diseases [PDF]

Hepatology Communications
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors involved in transcriptional regulation and play an important role in many physiological and metabolic processes.
Tomoo Yamazaki, Edward E. Cable, Bernd Schnabl   +2 more
doaj   +2 more sources

Role of peroxisome proliferator-activated receptor alpha in neurodegenerative diseases and other neurological disorders: Clinical application prospects [PDF]

Neural Regeneration Research
Peroxisome proliferator-activated receptor alpha is a member of the nuclear hormone receptor superfamily and functions as a transcription factor involved in regulating cellular metabolism.
Zijun Wu, Yuying Zhao, Shujing Hao, Mengyao An, Chengcheng Song, Jing Li   +5 more
doaj   +2 more sources

The role of peroxisome proliferator-activated receptors in the tumor microenvironment, tumor cell metabolism, and anticancer therapy

Frontiers in Pharmacology, 2023
Peroxisome proliferator-activated receptors (PPARs) have been extensively studied for over 3 decades and consist of three isotypes, including PPARα, γ, and β/δ, that were originally considered key metabolic regulators controlling energy homeostasis in ...
Jiaao Sun, Liyan Yu, Xueling Qu, Tao Huang   +3 more
doaj   +1 more source

Peroxisome Proliferator-Activated Receptors Regulate Hepatic Immunity and Assist in the Treatment of Primary Biliary Cholangitis

Frontiers in Immunology, 2022
Fibrates, which are agonists of peroxisome proliferator-activated receptor alpha, have received increasing attention in the treatment of primary biliary cholangitis.
Chang Wang, Chang Wang, Ying Shi, Ying Shi, Xiaomei Wang, Xiaomei Wang, Heming Ma, Heming Ma, Quan Liu, Yanhang Gao, Yanhang Gao, Junqi Niu, Junqi Niu   +12 more
doaj   +1 more source

PPAR? Downregulation by TGF in Fibroblast and Impaired Expression and Function in Systemic Sclerosis: A Novel Mechanism for Progressive Fibrogenesis [PDF]

, 2010
The nuclear orphan receptor peroxisome proliferator-activated receptor-gamma (PPAR-γ) is expressed in multiple cell types in addition to adipocytes. Upon its activation by natural ligands such as fatty acids and eicosanoids, or by synthetic agonists such
A Galli, A Kis, A Milano, AK Ghosh, AK Ghosh, AK Ghosh, AK Ghosh, Asish K. Ghosh, BC Willis, BM Psaty, C Beyer, C Dong, Carol Feghali-Bostwick, DA Culver, ED Rosen, ED Rosen, F Verrecchia, F Zheng, G Lakos, H Ha, HA Burgess, J Berger, J Varga, J Varga, JE Milam, Jennifer L. Sargent, JL Sargent, John Varga, Joy Sturtevant, JT Tan, Jun Wei, KA Longo, Kazuhiro Komura, KM Hong, L Fajas, L Yang, LS Higgins, M Dudas, M Kapoor, M Kapoor, M Lehrke, M Trojanowska, M Wu, Manu Jain, MF Simon, Michael L. Whitfield, Minghua Wu, OA Gressner, P Karnik, P Tontonoz, Qi-Quan Huang, R Fleischmajer, S Dennler, S Kim, S Sonnylal, S Zheng, SE Ross, SH Liu, SJ Chen, SZ Duan, T Kawai, T Miyahara, T Shiomi, TM McIntyre, V Zoete, W Yuan, X Li, X Liu, X Shi-wen, X Tan, Y Mori, Y Mori, Y Park, Y Shi, Y Wang, Z Yun   +75 more
core   +7 more sources

Potensi Terapeutik Fibroblast Growth Factor 21 terhadap Resistensi Insulin [PDF]

, 2015
Fibroblast growth factor 21 (FGF21) merupakan salah satu dari anggota FGF yang berperansebagai faktor endokrin. Hepar dan jaringan adiposa merupakan tempat kerja utama FGF21.Ekspresi FGF21 di hepar diatur oleh peroxisome proliferator activated receptor ...
Arozal, W. (Wawaimuli), Kurniasari, K. (Kurniasari)   +1 more
core   +2 more sources

Metabolic interactions between vitamin A and conjugated linoleic acid [PDF]

, 2014
Lipid-soluble molecules share several aspects of their physiology due to their common adaptations to a hydrophilic environment, and may interact to regulate their action in a tissue-specific manner.
BANNI, SEBASTIANO, Belury, MA, CARTA, GIANFRANCA, Cordeddu, L, Giordano, E, MURRU, MARIA ELISABETTA, Ortiz, B, Quadro, L   +7 more
core   +2 more sources

Peroxisome Proliferator-Activated Receptors [PDF]

Hypertension, 2003
Peroxisome proliferator-activated receptors (PPAR) are nuclear receptors acting as transcription factors on numerous target genes after heterodimerization with the retinoid X receptor. PPAR-α and PPAR-γ may be activated by different agonists, although the endogenous ligands are unknown.
Karen L. MacNaul, David E. Moller
openaire   +2 more sources

Increased peroxisome proliferator-activated receptor γ activity reduces imatinib uptake and efficacy in chronic myeloid leukemia mononuclear cells

Haematologica, 2017
Imatinib is actively transported by organic cation transporter-1 (OCT-1) influx transporter, and low OCT-1 activity in diagnostic chronic myeloid leukemia blood mononuclear cells is significantly associated with poor molecular response to imatinib ...
Jueqiong Wang, Liu Lu, Chung H. Kok, Verity A. Saunders, Jarrad M. Goyne, Phuong Dang, Tamara M. Leclercq, Timothy P. Hughes, Deborah L. White   +8 more
doaj   +1 more source