Results 81 to 90 of about 91,703 (262)

Pericentrosomal Redistribution of the Endoplasmic Reticulum Ensures Organelle Symmetric Inheritance and Mitotic Progression

Advanced Science, EarlyView.
Upon mitotic entry, RTN4 relocalizes to the pericentrosomal region, forming a more tubular ER network around centrosomes. CDK1‐mediated phosphorylation of RTN4 increases its interaction with Rab11 GTPase, facilitating dynein‐dependent transport of RTN4 to the pericentrosomal region.
Xiangyu Xu, Yalin Liu, Rongyi Wang, Wenwen Xu, Hao Shi, Ning Huang, Junlin Teng, Jin Meng, Pengli Zheng, Jianguo Chen   +9 more
wiley   +1 more source

Haplotype analysis of the PPARgamma Pro12Ala and C1431T variants reveals opposing associations with body weight. [PDF]

, 2002
BACKGROUND: Variation at the PPARG locus may influence susceptibility to type 2 diabetes and related traits. The Pro12Ala polymorphism may modulate receptor activity and is associated with protection from type 2 diabetes.
Frew, David, Flavell, DM, Cumming Alastair, Doney Alex, Palmer, CNA, Montgomery Hugh E, Hugh E Montgomery, Doney, A, Palmer, C N A, Doney, Alex; id_orcid, World Michael, Cumming, A, Montgomery, H E, Boyle, Douglas, World, Michael, Michael World, Andrew Morris, Morris, Andrew, David Frew, Montgomery, Hugh E., Fischer, Bettina, Palmer, Colin N.A.; id_orcid, Fischer, B, Alex Doney, Morris, A, Frew David, Alastair Cumming, World, M, Morris Andrew, Palmer Colin NA, David M Flavell, Cumming, Alastair, Montgomery, HE, Fischer Bettina, Flavell, David M., Frew, D, Douglas Boyle, Boyle, D, Bettina Fischer, Colin NA Palmer, Flavell David M, Boyle Douglas, Flavell, D M   +42 more
core   +1 more source

A Hydrogen Sulfide–Releasing Dynamic Hydrogel Modulates Coordinated Neurovascular, Immune, and Angiogenic Responses for Scar‐Suppressed Diabetic Wound Repair

Advanced Science, EarlyView.
ROS‐Responsive H2S Hydrogel (HAPPF) Coordinated Regeneration for High‐Quality Diabetic Wound Repair.A self‐regulating dynamic hydrogel is developed to deliver a fluorogenic H2S donor in response to excessive ROS. Released H2S acts as a master regulator to resolve chronic inflammation (M2 polarization), restore VEGF‐driven angiogenesis, and rebalance ...
Xuyang Ning, Ziqiang Zhou, Bangming Li, Hong Lu, Haoyang Wen, Zhoulong Huang, Gang Li, Ping Hu   +7 more
wiley   +1 more source

Deep Learning Network‐Tailored Microenvironment Matching of 4D Bioprinting Bioactive Scaffolds for Bone Regeneration

Advanced Science, EarlyView.
A DLN dataset was built to analyze MABS composition versus in vitro/in vivo osteogenesis and angiogenesis. An MLP neural network, taking BG morphological parameters as input, extracts bioactive features from these datasets. A rabbit tibial defect model then validates 4D‐printed MABS for adaptability and bone regeneration in critical defects.
Xiongjie Liang, Yuechi Zhang, Weifeng Hu, Shiyan Lv, Fan Jia, Yan Zhang, Feng Wu, Changjiang Yang, Guanqi Zhen, Jinglong Yan, Xu Cui, Wei Zhao, Guanghua Chen   +12 more
wiley   +1 more source

The role of the coactivators PGC-1α and PGC-1β in retina and skeletal muscle [PDF]

, 2011
Peroxisome proliferator-activated receptor γ coactivator- 1 (PGC-1) designates a family of coactivators consisting of PGC-1α, PGC-1β and PRC. By associating with transcription factors like nuclear receptors, they induce transcription of target genes that
Egger, A, Egger, Anna Franziska
core   +1 more source

Involvement of Cyclooxygenase-2 in Synergistic Effect of Cyclic Stretching and Eicosapentaenoic Acid on Adipocyte Differentiation

Journal of Pharmacological Sciences, 2008
The present study examined the combined effects of fish-oil-derived ω-3 polyunsaturated fatty acids, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and cyclic stretching on the adipocyte differentiation of 3T3-L1 cells.
Yoshiyuki Tanabe, Yumi Matsunaga, Maki Saito, Koichi Nakayama   +3 more
doaj   +1 more source

Pancreatic Atrophy: A Narrative Review and Surgical Interpretation

Annals of Gastroenterological Surgery, EarlyView.
Pancreatic parenchymal atrophy pattern and intraoperative margin assessment guide surgical strategy. ABSTRACT Despite recent advances in multimodal management, pancreatic ductal adenocarcinoma remains a fatal malignancy. Early detection of indirect findings of pancreatic ductal adenocarcinoma is essential to improve treatment outcomes, drawing ...
Rika Fujino, Ken‐ichi Okada, Yohei Masugi, Eisuke Iwasaki, Masaki Mori   +4 more
wiley   +1 more source

Inquiry of modulatory role of sea buckthorn fruit oil on dyslipidemia and gut microbiota in hyperlipidemia mice

Food Science and Human Wellness
Hyperlipidemia constitutes a critical factor in the pathogenesis of vascular disease and gut microbiota dysbiosis. This study aims to investigate the role of sea buckthorn fruit oil (SBFO) in ameliorating hyperlipidemia, modulating gut microbiota, and ...
Pimiao Huang, Zehua Chen, Wenzi Li, Aihua Su, Chun Cui   +4 more
doaj   +1 more source

Examination of Ligand-Dependent Coactivator Recruitment by Peroxisome Proliferator-Activated Receptor-α (PPARα)

PPAR Research, 2006
The ligand-dependent recruitment of coactivators to peroxisome proliferator-activated receptor-α (PPARα) was examined. PPAR-binding protein (PBP), PPARγ coactivator-1α (PGC-1α), steroid receptor coactivator-1 (SRC-1), and CBP/p300-interacting ...
Eric S. Tien, Daniel B. Hannon, Jerry T. Thompson, John P. Vanden Heuvel   +3 more
doaj   +1 more source

Possible mechanism of phthalates-induced tumorigenesis

Kaohsiung Journal of Medical Sciences, 2012
Phthalates—substances used in the manufacture of plastics—are considered as possible human carcinogens and tumor-promoting agents. The worldwide annual production of plastics surpassed 300 million tons in 2010.
Yu-Chih Wang, Hung-Sheng Chen, Cheng-Yu Long, Cheng-Fang Tsai, Tsung-Hua Hsieh, Chia-Yi Hsu, Eing-Mei Tsai   +6 more
doaj   +1 more source