Results 71 to 80 of about 91,703 (262)

G6PC Downregulation Promotes Renal Calcium Oxalate Stone Formation via Lactate‐Induced SNAIL1 K206 Lactylation and Epithelial‐Mesenchymal Transition

Advanced Science, EarlyView.
In renal calcium oxalate stone formation, G6PC downregulation leads to lactate accumulation. This lactate mediates CBP/p300‐dependent lactylation of SNAIL1 at K206, promoting its nuclear translocation. Nuclear SNAIL1 activates the TGF‐β/SMAD3 pathway, driving epithelial‐mesenchymal transition and fibrosis, which ultimately facilitates crystal ...
Kai Liu, Boming Zhang, Ruixin Fan, Chen Duan, Yangjun Zhang, Huahui Wu, Xiangyang Yao, Xiongmin Mao, Bo Li, Youmiao Zeng, Zhenzhen Xu, Yang Wang, Mengcheng Luo, Xinyu Xu, Ninghan Feng, Heng Li, Hua Xu   +16 more
wiley   +1 more source

Janus kinase 2 inhibition by pacritinib as potential therapeutic target for liver fibrosis

Hepatology, EarlyView., 2022
Diagram of the activation of the profibrotic and procontractile Janus kinase 2 (JAK2)/Ras homolog family member A/Rho‐kinase pathway and the inhibition of phosphorylated JAK2 by pacritinib to inhibit hepatic stellate cell activity. Abstract Background and Aims Janus kinase 2 (JAK2) signaling is increased in human and experimental liver fibrosis with ...
Sandra Torres, Cristina Ortiz, Nadine Bachtler, Wenyi Gu, Leon D. Grünewald, Nico Kraus, Robert Schierwagen, Christoph Hieber, Caroline Meier, Olaf Tyc, Maximilian Joseph Brol, Frank Erhard Uschner, Bart Nijmeijer, Christoph Welsch, Marie‐Luise Berres, Carmen Garcia‐Ruiz, Jose Carlos Fernandez‐Checa, Christian Trautwein, Thomas J. Vogl, Stefan Zeuzem, Jonel Trebicka, Sabine Klein   +21 more
wiley   +1 more source

Endogenous Epoxygenases Are Modulators of Monocyte/Macrophage Activity [PDF]

, 2011
Background: Arachidonic acid is metabolized through three major metabolic pathways, the cyclooxygenase, lipoxygenase and CYP450 enzyme systems. Unlike cyclooxygenase and lipoxygenases, the role of CYP450 epoxygenases in monocyte/macrophage-mediated ...
Bishop-Bailey, D, Mary C Sugden, David Bishop-Bailey, Bystrom, J, Holness Mark J., Sugden, MC, Mark J Holness, Holness, MJ, Jessica A. Wray, Wray, JA, Sugden, M C, Matthew L. Edin, Zeldin Darryl C., Zeldin, DC, Karen E Swales, Edin Matthew L., Edin, ML, Zeldin, D C, Sugden Mary C., Wray, J A, Gilroy Derek W., Swales Karen E., Darryl C Zeldin, Gilroy, DW, Derek W Gilroy, Karen E. Swales, Edin, M L, Mark J. Holness, Matthew L Edin, Derek W. Gilroy, Wray Jessica A., Gilroy, D W, Warner Timothy D., Jonas Bystrom, Warner, T D, Darryl C. Zeldin, Timothy D. Warner, Bishop-Bailey David, Bystrom Jonas, Holness, M J, Jessica A Wray, Swales, K E, Warner, TD, Timothy D Warner, Swales, KE, Mary C. Sugden   +45 more
core   +1 more source

Metabolomics reveal 1-palmitoyl lysophosphatidylcholine production by peroxisome proliferator-activated receptor α[S]

Journal of Lipid Research, 2015
PPARα is well known as a master regulator of lipid metabolism. PPARα activation enhances fatty acid oxidation and decreases the levels of circulating and cellular lipids in obese diabetic patients.
Haruya Takahashi, Tsuyoshi Goto, Yota Yamazaki, Kosuke Kamakari, Mariko Hirata, Hideyuki Suzuki, Daisuke Shibata, Rieko Nakata, Hiroyasu Inoue, Nobuyuki Takahashi, Teruo Kawada   +10 more
doaj   +1 more source

NMI Regulates Adipose Adaptive Thermogenesis Through TLR4/IRF3 Signaling to Promote Obesity

Advanced Science, EarlyView.
Adipose tissue‐derived NMI is secreted under metabolic stress and suppresses adaptive thermogenesis through TLR4/IRF3 signaling, repressing the PPARα/PGC‐1α/UCP1 thermogenic transcriptional program. Genetic ablation or anti ‐ NMI monoclonal antibody treatment enhances energy expenditure, protects against DIO, and ameliorates adipose tissue inflammation,
Ting‐Ting Li, Xin‐Yuan Zhao, Min Zhang, Zhuang‐Feng Weng, Xiao‐Ran Guo, Ying‐Fang Liu, Qiao‐Ping Wang, Huan‐Huan Liang   +7 more
wiley   +1 more source

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

Antigen Spreading via Localized Administration Enhances Adoptive TCR‐T Cell Therapy in Pancreatic Cancer

Advanced Science, EarlyView.
Cancer vaccines face limitations in pancreatic cancer due to insufficient tumor antigens. This ionic liquid ILvax via local tumor delivery triggers robust cDC1‐dependent systemic anti‐tumor immunity. It boosts endogenous CD8+ T cells and optimizes adoptive TCR‐T function, providing a promising synergistic therapeutic strategy.
Junming Huang, Qin Wang, Zhuo Yao, Qing Wang, Yongtao Ji, Minqi Yang, Meng Wang, Shiyi Shao, Xinyu Zhao, Fu Zhang, Tingbo Liang, Qida Hu   +11 more
wiley   +1 more source

PGC-1a in muscle links metabolism to inflammation [PDF]

, 2009
1. In higher eukaryotes, metabolism and immunity are tightly coupled. However, whereas in evolutionary terms, a compromised immune response due to undernourishment has been the predominant problem, the inflammatory response to obesity and other life ...
Handschin, C.
core  

Tributyltin is a potent inhibitor of piscine peroxisome proliferator-activated receptor α and β [PDF]

, 2011
Increasing evidence suggests that common environmental contaminants can act as endocrine disrupters in fish. However, current data are biased towards environmental estrogens, highlighting the need to elucidate potential pollutant impact on other ...
Colliar, Louise, Sturm, Armin, Armin Sturm, Michael J. Leaver, Leaver, Michael, Louise Colliar   +5 more
core   +1 more source

Peroxisome proliferator-activated receptor α-independent peroxisome proliferation [PDF]

, 2015
Hepatic peroxisome proliferation, increases in the numerical and volume density of peroxisomes, is believed to be closely related to peroxisome proliferator-activated receptor α (PPARα) activation; however, it remains unknown whether peroxisome ...
Aoyama, T, Zhang, XG, Kamijo, Y, Nakajima, T, Tanaka, N, Gonzalez, FJ   +5 more
core   +2 more sources