Results 51 to 60 of about 91,703 (262)

Oral Bioinspired Peroxisome‐Engineered Probiotics for Modulating Gut Microbiota Homeostasis and Alleviating Cardiac Chemotherapy Toxicity

Advanced Science, EarlyView.
This study developed an oral bioinspired peroxisome‐engineered probiotic (BPEP) by anchoring lipid‐encapsulated ruthenium nanozymes onto Escherichia coli Nissle 1917, utilizing probiotics to deliver nanozymes to the intestinal barrier for reactive oxygen species/reactive nitrogen species elimination, tight junction restoration, and gut microbiota ...
Shuyu Wang, Xiaowan Fan, Chao Zhang, Shuai Han, Yike Guo, Yuchen Wang, Wei Wang, Junyue Xing, Ying Liu, Wei Jiang, Xiaoying Chen   +10 more
wiley   +1 more source

Kinetic characterization of selective peroxisome-proliferator-activated receptor gamma modulators in vitro

, 2012
Background: The ligand-activated transcription factor, peroxisome-proliferator-activated receptor gamma (PPARγ), has been shown to play an essential role in immunosuppression during sepsis.
Parnham, Michael J., Kuchler, Laura, Brüne, Bernhard, Knape, Tilo, Heeg, Annika, Eifler, Lisa, Knethen, Andreas von   +6 more
core   +1 more source

Regulation of ABCA1 expression in human keratinocytes and murine epidermis

Journal of Lipid Research, 2006
Keratinocytes require abundant cholesterol for cutaneous permeability barrier function; hence, the regulation of cholesterol homeostasis is of great importance.
Yan J. Jiang, Biao Lu, Peggy Kim, Peter M. Elias, Kenneth R. Feingold   +4 more
doaj   +1 more source

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

Advanced Science, EarlyView.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin, Wei Luo, Zhengyuan Fang, Zhufeng Hu, Kunlun Feng, Xinrong Li, Dan Wu, Bowen Han, James Hoi po Hui, Xuanyong Liu, Chen Chen, Gang Chen, Shiyi Chen, Nirong Bao, Jiajun Qiu, Zhiwen Luo   +24 more
wiley   +1 more source

NAFLD‐related hepatocellular carcinoma: The growing challenge

Hepatology, EarlyView., 2022
Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah, Rashmee Patil, Stephen A. Harrison   +2 more
wiley   +1 more source

Peroxisome proliferator-activated receptor α (PPARα) and agonist inhibit cholesterol 7α-hydroxylase gene (CYP7A1) transcription

Journal of Lipid Research, 2000
Fibrates are widely used hypolipidemic drugs that regulate the expression of many genes involved in lipid metabolism by activating the peroxisome proliferator-activated receptor α (PPARα).
Maria Marrapodi, John Y.L. Chiang
doaj   +1 more source

Multi‐Omics Insights Into the Mechanisms of Early Muscle Fiber Difference and Transformation Between Lean‐Type and Chinese Indigenous Pigs

Advanced Science, EarlyView.
Multi‐omics analyses uncover breed‐specific cis‐regulatory landscapes and higher‐order chromatin architectural differences that underlie early postnatal muscle fiber divergence in pigs. A super‐enhancer upstream of PPP3CB recruits MEF2C to activate PPP3CB transcription, while the PPP3CB–MEF2C positive feedback loop promotes oxidative muscle fiber ...
Shuailong Zheng, Hainan Wu, Min Liu, Kunpeng Wu, Shuntao Huang, Zulfiqar Ahmed, Lenox Pius, Mengjin Zhu, Dequan Xu   +8 more
wiley   +1 more source

Myeloid p38 activation maintains macrophage–liver crosstalk and BAT thermogenesis through IL‐12–FGF21 axis

Hepatology, EarlyView., 2022
Physiological activation of myeloid p38 controls macrophage IL‐12 production and crosstalk to the liver by modulating hepatic FGF21, and subsequently, brown adipose tissue thermogenesis during obesity Abstract Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to ...
María Crespo, Ivana Nikolic, Alfonso Mora, Elena Rodríguez, Luis Leiva‐Vega, Aránzazu Pintor‐Chocano, Daniel Horrillo, Lourdes Hernández‐Cosido, Jorge L. Torres, Eva Novoa, Rubén Nogueiras, Gema Medina‐Gómez, Miguel Marcos, Magdalena Leiva, Guadalupe Sabio   +14 more
wiley   +1 more source

Beta-carotene Reduces Body Adiposity of Mice Via BCMO1 [PDF]

, 2011
Evidence from cell culture studies indicates that ß-carotene-(BC)-derived apocarotenoid signaling molecules can modulate the activities of nuclear receptors that regulate many aspects of adipocyte physiology.
Yvonne G. J. van Helden, Georg Lietz, Kiec-Wilk, B., Andreu Palou, Adrian Wyss, von Lintig, J., Jean François Landrier, Landrier, Jean-Francois, Ursula Razny, Lietz, G., Raźny, Urszula, Kramer, E.H.M., Amengual, J., Wyss, A., Kramer, Evelien, Lietz, Georg, Gouranton, Erwan, M. Luisa Bonet, Razny, Ursula, Beata Kiec-Wilk, van Helden, Y.G., M Luisa Bonet, Joan Ribot, Susanne Hessel, Aldona Dembinska-Kiec, Jaap Keijer, Landrier, Jean François, Yvonne G J van Helden, Keijer, J., Hessel, S., Dembinska-Kiec, Aldona, Amengual, Jaume, Keijer, Jaap, Landrier, J. F., Bonet, M. Luisa, Ribot, Joan, Kramer, E., Dembinska-Kiec, A., Gouranton, E., Palou, Andreu, Kiec-Wilk, Beata, Ribot, J., Erwan Gouranton, Palou, A., Razny, U., Helden, Y.G.J., Johannes von Lintig, Wyss, Adrian, Hessel, Susanne, Evelien Kramer, van Helden, Yvonne G. J., Luisa Bonet, M., von Lintig, Johannes, Bonet, M.L., Jaume Amengual   +54 more
core   +1 more source

PPAR-α activator pemafibrate lowered plasma insulin-like growth factor-1 level in a patient with acromegaly

Endocrinology, Diabetes & Metabolism Case Reports
This is a report of a patient with acromegaly that was ameliorated by pemafibrate, a peroxisome proliferator-activated receptor-α (PPAR-α) activator. Baseline acromegaly medication for this patient was lanreotide (90 mg/month).
Go Yoshimichi
doaj   +1 more source