Results 31 to 40 of about 91,703 (262)

Role of metabolic nuclear receptors in acute liver injury and drug-induced hepatotoxicity

Pharmacological Research
Metabolic nuclear receptors (NRs) are ligand-activated transcription factors central to metabolic homeostasis and detoxification. While their roles in chronic liver diseases have been reviewed, comprehensive reviews specifically addressing the role of ...
Liangliang Nie, Nana Yan, Frank J. Gonzalez, Haiping Hao, Tingting Yan   +4 more
doaj   +1 more source

Developmental and tissue-specific involvement of peroxisome proliferator-activated receptor-alpha in the control of mouse uncoupling protein-3 gene expression.

, 2013
Uncoupling protein-3 (UCP3) is a member of the mitochondrial carrier family expressed preferentially in skeletal muscle and heart. It appears to be involved in metabolic handling of fatty acids in a way that minimizes excessive production of reactive ...
Villarroya i Gombau, Francesc, Villarroya i Terrade, Joan, Gonzalez, Frank J., Solanes Garcia, Gemma, Pedraza González, Neus, Rosell Mañé, Meritxell, Iglesias Coll, María del Rosario   +6 more
core   +1 more source

Variants of the human PPARG locus and the susceptibility to chronic periodontitis [PDF]

, 2011
Apart from its regulatory function in lipid and glucose metabolism, peroxisome proliferator-activated receptor (PPAR)γ has impact on the regulation of inflammation and bone metabolism.
Manolis, Vasilios, Matthias Folwaczny, Glas, Jürgen, Christian Markus, Vasilios Manolis, Markus, Christian, Folwaczny, Matthias, Jürgen Glas   +7 more
core   +1 more source

Peroxisome proliferator-activated receptor α polymorphisms and postprandial lipemia in healthy men

Journal of Lipid Research, 2007
Peroxisome proliferator-activated receptor α (PPARα) is a ligand-dependent transcription factor that plays a key role in lipid and glucose homeostasis. This study evaluated whether variants of PPARα are associated with postprandial lipemia. Subjects were
Toshiko Tanaka, Jose M. Ordovas, Javier Delgado-Lista, Francisco Perez-Jimenez, Carmen Marin, Pablo Perez-Martinez, Purificacion Gomez, Jose Lopez-Miranda   +7 more
doaj   +1 more source

Skin-targeted inhibition of PPAR β/δ by selective antagonists to treat PPAR β/δ-mediated psoriasis-like skin disease in vivo [PDF]

, 2012
We have previously shown that peroxisome proliferator activating receptor ß/d (PPAR ß/d is overexpressed in psoriasis. PPAR ß/d is not present in adult epidermis of mice.
Kevin D. Read (165019), Palmer Colin, Kally Booth, Katrin Hack, Booth Kally, Colin Palmer (165015), Suzanne Norval, Read, Kevin D, Hack Katrin, John Foerster (165047), Robert Kime, Kevin D Read, John Foerster, Kally Booth (165039), Louise Reilly, Suzanne Norval (165024), Read Kevin D., Palmer, Colin; id_orcid, Norval, Suzanne, Reilly, Louise, Louise Reilly (165006), Reilly Louise, Read, Kevin, Palmer, Colin, Hack, Katrin, Robert Kime (165030), Colin Palmer, Kime Robert, Foerster John, Foerster, John, Katrin Hack (165002), Kime, Robert, Norval Suzanne, Booth, Kally   +33 more
core   +1 more source

Additional file 1: of Associations between hypertension and the peroxisome proliferator-activated receptor-δ (PPARD) gene rs7770619 C>T polymorphism in a Korean population

, 2018
Table S1. Top 10 SNPs associated with plasma MDA. Figure S1. Flow of the study participants. (DOCX 112 kb)
Kim, Minjoo, Kim, Minkyung, Yoo, Hye, Shon, Jayoung, Lee, Jong   +4 more
openaire   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

New insights in the regulation of skeletal muscle PGC-1α by exercise and metabolic diseases [PDF]

, 2013
Skeletal muscle energy metabolism is severely impaired in insulin resistant and type 2 diabetic patients. In particular, deregulated transcription of oxidative metabolism genes has been linked to the development of non-communicable metabolic diseases ...
Handschin, Christoph, Pérez-Schindler, Joaquín   +1 more
core   +1 more source

Targeting Peroxisome Proliferator Activated Receptor α (PPAR α) for the Prevention of Mitochondrial Impairment and Hypertrophy in Cardiomyocytes

Cellular Physiology and Biochemistry, 2018
Background/Aims: Morphological and biochemical maladaptation of cardiomyocytes are associated with mitochondrial dysfunction and dysregulation in hypertrophic conditions.
Dipak Kar, Arun  Bandyopadhyay
doaj   +1 more source

Peroxisome proliferator-activated receptor α activation induces hepatic steatosis, suggesting an adverse effect. [PDF]

PLoS ONE, 2014
Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic triglyceride accumulation, ranging from steatosis to steatohepatitis and cirrhosis.
Fang Yan, Qi Wang, Chao Xu, Mingfeng Cao, Xiaoming Zhou, Tingting Wang, Chunxiao Yu, Fei Jing, Wenbin Chen, Ling Gao, Jiajun Zhao   +10 more
doaj   +1 more source