Results 21 to 30 of about 91,703 (262)

Hepatic triacylglycerol hydrolysis regulates peroxisome proliferator-activated receptor α activity

Journal of Lipid Research, 2009
Recent evidence suggests that fatty acids generated from intracellular triacylglycerol (TAG) hydrolysis may have important roles in intracellular signaling.
Jessica M. Sapiro, Mara T. Mashek, Andrew S. Greenberg, Douglas G. Mashek   +3 more
doaj   +1 more source

Peroxisome proliferator-activated receptor γ coactivator 1 coactivators, energy homeostasis, and metabolism [PDF]

, 2006
Many biological programs are regulated at the transcriptional level. This is generally achieved by the concerted actions of several transcription factors. Recent findings have shown that, in many cases, transcriptional coactivators coordinate the overall
Christoph Handschin, Bruce M. Spiegelman, Handschin, C., Spiegelman, B. M.   +3 more
core   +1 more source

Lipid-Induced Hepatocyte-Derived Extracellular Vesicles Regulate Hepatic Stellate Cells via MicroRNA Targeting Peroxisome Proliferator-Activated Receptor-γ

Cellular and Molecular Gastroenterology and Hepatology, 2015
BACKGROUND & AIMS: Hepatic stellate cells (HSCs) play a key role in liver fibrosis in various chronic liver disorders including nonalcoholic fatty liver disease (NAFLD). The development of liver fibrosis requires a phenotypic switch from quiescent to activated HSCs. The trigger for HSC activation in NAFLD remain poorly understood.
Povero D, Panera N, Eguchi A, Johnson CD, Papouchado BG, de Araujo Horcel L, Pinatel EM, Alisi A, Nobili V, Feldstein AE.   +9 more
openaire   +4 more sources

Lipidomic profiling reveals protective function of fatty acid oxidation in cocaine-induced hepatotoxicity

Journal of Lipid Research, 2012
During cocaine-induced hepatotoxicity, lipid accumulation occurs prior to necrotic cell death in the liver. However, the exact influences of cocaine on the homeostasis of lipid metabolism remain largely unknown. In this study, the progression of subacute
Xiaolei Shi, Dan Yao, Blake A. Gosnell, Chi Chen   +3 more
doaj   +1 more source

Peroxisome proliferator-activated receptor-γ coactivator-1α in muscle links metabolism to inflammation [PDF]

, 2009
1. In higher eukaryotes, metabolism and immunity are tightly coupled. However, whereas evolutionary, a compromised immune response due to undernourishment has been the predominant problem, the inflammatory response to obesity and other life style ...
Handschin, C., Handschin, C
core   +1 more source

Peroxisome proliferator-activated receptor α controls cellular cholesterol trafficking in macrophages

Journal of Lipid Research, 2005
The mobilization of cholesterol from intracellular pools to the plasma membrane is a determinant that governs its availability for efflux to extracellular acceptors.
G. Chinetti-Gbaguidi, E. Rigamonti, L. Helin, A.L. Mutka, M. Lepore, J.C. Fruchart, V. Clavey, E. Ikonen, S. Lestavel, B. Staels   +9 more
doaj   +1 more source

Regulation of skeletal muscle cell plasticity by the peroxisome proliferator-activated receptor gamma coactivator 1alpha [PDF]

, 2010
Exercise triggers a pleiotropic response in skeletal muscle, which results in a profound remodeling of this tissue. Physical activity-dependent muscle fiber plasticity is regulated by a number of distinct signaling pathways.
Handschin, C.
core   +1 more source

The Peroxisome Proliferator-activated Receptor γ (PPARγ) Controls Natural Protective Mechanisms against Lipid Peroxidation in Amyotrophic Lateral Sclerosis [PDF]

, 2012
Recent evidence highlights the peroxisome proliferator-activated receptors (PPARs) as critical neuroprotective factors in several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). To gain new mechanistic insights into the role of
Maggi, Adriana, L. Brambilla, Benedusi, Valeria, Brambilla, Liliana, A. Maggi, V. Benedusi, Martorana, Francesca, F. Martorana, Rossi, Daniela   +8 more
core   +1 more source

Effect of berberine on PPARα-NO signalling pathway in vascular smooth muscle cell proliferation induced by angiotensin IV

Pharmaceutical Biology, 2017
Context: The available treatments for the abnormal proliferation of vascular smooth muscle cells (VSMCs) are still dismal. Berberine has been demonstrated to possess extensive medicine activity, yet relatively little is known about its effect on VSMCs ...
Hongmei Qiu, Yang Wu, Quanhua Wang, Changqing Liu, Lai Xue, Hong Wang, Qin Wu, Qingsong Jiang   +7 more
doaj   +1 more source

Activation of peroxisome proliferator-activated receptor alpha in human peripheral blood mononuclear cells reveals an individual gene expression profile response

, 2007
Peripheral blood mononuclear cells (PBMCs) are relatively easily obtainable cells in humans. Gene expression profiles of PBMCs have been shown to reflect the pathological and physiological state of a person.
Afman, Lydia A., Bouwens, M., Müller, Michael, Müller Michael, Afman, Lydia, Afman, Lydia A, Afman, L.A., Michael Müller, Bouwens Mark, Müller, M.R., Mark Bouwens, Afman Lydia A, Bouwens, Mark, Lydia A Afman   +13 more
core   +1 more source