Results 11 to 20 of about 91,703 (262)

Stimulation of Alpha-1-Adrenergic Receptor Ameliorates Obesity-Induced Cataracts by Activating Glycolysis and Inhibiting Cataract-Inducing Factors [PDF]

Endocrinology and Metabolism, 2022
Background Obesity, the prevalence of which is increasing due to the lack of exercise and increased consumption of Westernized diets, induces various complications, including ophthalmic diseases. For example, obesity is involved in the onset of cataracts.
Yong-Jik Lee, Yoo-Na Jang, Hyun-Min Kim, Yoon-Mi Han, Hong Seog Seo, Youngsub Eom, Jong-suk Song, Ji Hoon Jeong, Tae Woo Jung   +8 more
doaj   +1 more source

Intestinal peroxisome proliferator-activated receptor α-fatty acid-binding protein 1 axis modulates nonalcoholic steatohepatitis. [PDF]

Hepatology, 2023
Abstract Background and Aims Peroxisome proliferator‐activated receptor α (PPARα) regulates fatty acid transport and catabolism in liver. However, the role of intestinal PPARα in lipid homeostasis is largely unknown. Here, intestinal PPARα was examined for its modulation of obesity and NASH. Approach and Results Intestinal PPARα was activated and fatty
Yan T, Luo Y, Yan N, Hamada K, Zhao N, Xia Y, Wang P, Zhao C, Qi D, Yang S, Sun L, Cai J, Wang Q, Jiang C, Gavrilova O, Krausz KW, Patel DP, Yu X, Wu X, Hao H, Liu W, Qu A, Gonzalez FJ.   +22 more
europepmc   +2 more sources

Targeting PPARα in low ambient temperature exposure-induced cardiac dysfunction and remodeling

Military Medical Research, 2021
The present study demonstrates that the down-regulation of peroxisome proliferator-activated receptor-α (PPARα) results in chronic low ambient temperature (LT) exposure-induced cardiac dysfunction and remodeling, emphasizing the therapeutic potential of ...
Xi-Yao Chen, Yang Jiao, Fu-Yang Zhang
doaj   +1 more source

The case for intraocular delivery of PPAR agonists in the treatment of diabetic retinopathy

BMC Ophthalmology, 2012
Background Systemic therapeutics targeting the peroxisome proliferator-activated receptors have been found to be beneficial in the treatment of diabetic retinopathy.
Treacy Maxwell P, Hurst Tara P
doaj   +1 more source

Peroxisome Proliferator-Activated Receptor Alpha Target Genes [PDF]

, 2010
The peroxisome proliferator-activated receptor alpha (PPARα) is a ligand-activated transcription factor involved in the regulation of a variety of processes, ranging from inflammation and immunity to nutrient metabolism and energy homeostasis.
Rakhshandehroo, M., Rakhshandehroo, Maryam, Knoch, Bianca, Kersten, A.H., Müller, Michael, Bianca Knoch, Maryam Rakhshandehroo, Sander Kersten, Michael Müller, Knoch, B., Kersten, Sander, Müller, M.R.   +11 more
core   +1 more source

Hepatic peroxisome proliferator-activated receptor γ and α-mRNA expression in HCV-infected adults is decreased by HIV co-infection and is also affected by ethnicity

Clinics, 2015
OBJECTIVE: To determine peroxisome proliferator activated receptor α and γ mRNA expression in liver tissue of hepatitis C virus-infected patients with and without human immunodeficiency virus and its possible contribution to an acceleration of liver ...
Nathan J. Shores, Maria Cássia Mendes-Corrêa, Ivana Maida, JoLyn Turner, Kevin P. High, Sergio Babudieri, Marina Núãez   +6 more
doaj   +1 more source

Peroxisome Proliferator Activated Receptors and Lipoprotein Metabolism [PDF]

, 2008
Plasma lipoproteins are responsible for carrying triglycerides and cholesterol in the blood and ensuring their delivery to target organs. Regulation of lipoprotein metabolism takes place at numerous levels including via changes in gene transcription.
Kersten, A.H., Sander Kersten
core   +1 more source

Peroxisome proliferator-activated receptor-α accelerates α-chlorofatty acid catabolism

Journal of Lipid Research, 2017
α-Chlorofatty aldehydes are generated from myeloperoxidase-derived HOCl targeting plasmalogens, and are subsequently oxidized to α-chlorofatty acids (α-ClFAs). The catabolic pathway for α-ClFA is initiated by ω-oxidation.
ElisaN.D. Palladino, Wen-yi Wang, Carolyn J. Albert, Cédric Langhi, Ángel Baldán, David A. Ford   +5 more
doaj   +1 more source

The diabetes medication canagliflozin promotes mitochondrial remodelling of adipocyte via the AMPK-Sirt1-Pgc-1α signalling pathway

Adipocyte, 2020
The diabetes medication canagliflozin (Cana) is a sodium glucose cotransporter 2 (SGLT2) inhibitor acting by increasing urinary glucose excretion and thus reducing hyperglycaemia. Cana treatment also reduces body weight.
Xuping Yang, Qinhui Liu, Yanping Li, Qin Tang, Tong Wu, Lei Chen, Shiyun Pu, Yingnan Zhao, Guorong Zhang, Cuiyuan Huang, Jinhang Zhang, Zijing Zhang, Ya Huang, Min Zou, Xiongjie Shi, Wei Jiang, Rui Wang, Jinhan He   +17 more
doaj   +1 more source

WITHDRAWN: Mouse Trefoil Factor 3 (Tff3) Ameliorates Fatty Liver Phenotype via Increasing Peroxisome Proliferator-activated Receptor-α (PPARα) Expression

Oncotarget, 2017
// Xiaojie Wu 1, * , Haiyong Jin 2, * , Yueling Zhang 3 , Mingyuan Dong 3 , Xiaoting Wu 3 , Jiadi Zhou 1 , Weishan Zhuge 4 , Jianjing Yang 5 , Qichuan Zhuge 5 , Xiying Luan 1 , Dexiang Ban 6 , Wenjie Zhu 3 , Yongjun Jin 7 and Jiangnan Xue 1 1 Department of Immunology, Binzhou Medical University, Yantai, China 2 Department of ...
Xiaojie Wu, Xiaojie Wu, Haiyong Jin, Haiyong Jin, Yueling Zhang, Yueling Zhang, Mingyuan Dong, Mingyuan Dong, Xiaoting Wu, Xiaoting Wu, Jiadi Zhou, Jiadi Zhou, Weishan Zhuge, Weishan Zhuge, Jianjing Yang, Jianjing Yang, Qichuan Zhuge, Qichuan Zhuge, Xiying Luan, Xiying Luan, Dexiang Ban, Dexiang Ban, Wenjie Zhu, Wenjie Zhu, Yongjun Jin, Yongjun Jin, Jiangnan Xue, Jiangnan Xue   +27 more
openaire   +1 more source