Results 41 to 50 of about 91,703 (262)

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) but not PPARalpha serves as a plasma free fatty acid sensor in liver

, 2009
Peroxisome proliferator-activated receptor alpha (PPARalpha) is an important transcription factor in liver that can be activated physiologically by fasting or pharmacologically by using high-affinity synthetic agonists.
Degenhardt, Tatjana, Degerhardt, T., Kersten, A.H., Müller, Michael, Koppen, A., Sanderson, L., Kalkhoven, E., Müller, M.R., Koppen, Arjen, Sanderson, Linda M, Desvergne, Beatrice, Desvergne, B., Kalkhoven, Eric, Kersten, Sander   +13 more
core   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

The biology of PGC-1alpha and its therapeutic potential [PDF]

, 2009
In eukaryotes, cellular and systemic metabolism is primarily controlled by mitochondrial activity. The peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) is an important regulator of mitochondrial biogenesis and function ...
Handschin, C., Handschin, C
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Loss of Renal Tubular PGC-1α Exacerbates Diet-Induced Renal Steatosis and Age-Related Urinary Sodium Excretion in Mice [PDF]

, 2016
The kidney has a high energy demand and is dependent on oxidative metabolism for ATP production. Accordingly, the kidney is rich in mitochondria, and mitochondrial dysfunction is a common denominator for several renal diseases.
Handschin, Christoph, Kristoffer Svensson, Schnyder, Svenia, Christoph Handschin, Kristoffer Svensson (593634), Svenia Schnyder (3146877), Svensson, Kristoffer, Bettina Cardel (3146880), Svenia Schnyder, Christoph Handschin (184204), Cardel, Bettina, Bettina Cardel   +11 more
core   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

PPARalpha-mediated effects of dietary lipids on intestinal barrier gene expression [PDF]

, 2008
Background The selective absorption of nutrients and other food constituents in the small intestine is mediated by a group of transport proteins and metabolic enzymes, often collectively called 'intestinal barrier proteins'.
Hooiveld, Guido J E J, Bosch, H.M., van den, de Groot, Philip, de Vogel-van den Bosch, Heleen, de Groot Philip J, de Groot, P.J., Hooiveld Guido JEJ, de Vogel-van den Bosch Heleen M, Müller, M.R., Bosch-Vermeulen, Hanneke, Heleen M de Vogel-van den Bosch, Hooiveld, Guido, Bosch - Vermeulen, Hanneke, Philip J de Groot, Bünger, Meike, Bosch-Vermeulen Hanneke, Bünger Meike, de Vogel-van den Bosch, Heleen M, Müller Michael, Müller, Michael, Meike Bünger, Michael Müller, Hanneke Bosch-Vermeulen, Bosch-Vermeulen, H., van den Bosch, H.M., Bünger, M., Groot, P.J., de, Guido JEJ Hooiveld, Heleen M de Vogel-van den Bosch, Hooiveld, G.J.E.J., de Groot, Philip J   +30 more
core   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Clitorin ameliorates western diet-induced hepatic steatosis by regulating lipogenesis and fatty acid oxidation in vivo and in vitro

Scientific Reports, 2022
Nonalcoholic fatty liver disease (NAFLD) is usually correlated with metabolic diseases, such as obesity, insulin resistance, and hyperglycemia. Herein, we investigated the inhibitory effects and underlying governing mechanism of clitorin in a western ...
Divina C. Cominguez, Yea-Jin Park, Yun-Mi Kang, Agung Nugroho, Suhyun Kim, Hyo-Jin An   +5 more
doaj   +1 more source