Peroxisome proliferator-activated receptor delta limits the expansion of pathogenic Th cells during central nervous system autoimmunity. [PDF]
, 2010 Peroxisome proliferator-activated receptors (PPARs; PPAR-alpha, PPAR-delta, and PPAR-gamma) comprise a family of nuclear receptors that sense fatty acid levels and translate this information into altered gene transcription.
Axtell, Robert +11 more
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Complex coordination of cell plasticity by a PGC-1α-controlled transcriptional network in skeletal muscle [PDF]
, 2015 Skeletal muscle cells exhibit an enormous plastic capacity in order to adapt to external stimuli. Even though our overall understanding of the molecular mechanisms that underlie phenotypic changes in skeletal muscle cells remains poor, several factors ...
Agrawal +52 more
core +4 more sources
The PPARγ2 P12A polymorphism is not associated with all-cause mortality in patients with type 2 diabetes mellitus [PDF]
, 2016 The high mortality risk of patients with type 2 diabetes mellitus may well be explained by the several comorbidities and/or complications. Also the intrinsic genetic component predisposing to diabetes might have a role in shaping the risk of diabetes ...
Alberico, Federica +13 more
core +1 more source
PPM1A Controls Diabetic Gene Programming through Directly Dephosphorylating PPAR?? at Ser273 [PDF]
, 2020 Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a master regulator of adipose tissue biology. In obesity, phosphorylation of PPAR gamma at Ser273 (pSer273) by cyclin-dependent kinase 5 (CDK5)/extracellular signal-regulated kinase (ERK ...
Choi, Jang Hyun +11 more
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Tumor Biology, 2017 Peroxisome proliferator-activated receptor gamma coactivator-1 alpha plays a crucial role in regulating the biosynthesis of mitochondria, which is closely linked to the energy metabolism in various tumors.
Rui Liu +11 more
doaj +1 more source
Variants of the human PPARG locus and the susceptibility to chronic periodontitis [PDF]
, 2011 Apart from its regulatory function in lipid and glucose metabolism, peroxisome proliferator-activated receptor (PPAR)γ has impact on the regulation of inflammation and bone metabolism.
Desvergne B +5 more
core +1 more source
Screening of Prognostic Factors in Early-Onset Breast Cancer
Technology in Cancer Research & Treatment, 2020 Background: Gene expression profiles from early-onset breast cancer and normal tissues were analyzed to explore the genes and prognostic factors associated with breast cancer.
Zhun Yu MM, Qi He BM, Guoping Xu MM
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The Role of Peroxisome Proliferator-Activated Receptors in Preeclampsia
Cells, 2023 Preeclampsia is a common pregnancy-related hypertensive disorder. Often presenting as preexisting or new-onset hypertension complicated by proteinuria and/or end-organ dysfunction, preeclampsia significantly correlates with maternal and perinatal ...
Iason Psilopatis +3 more
doaj +1 more source
Respiratory Research, 2005 Research into respiratory diseases has reached a critical stage and the introduction of novel therapies is essential in combating these debilitating conditions.
Lin Diana +4 more
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The case for intraocular delivery of PPAR agonists in the treatment of diabetic retinopathy
BMC Ophthalmology, 2012 Background Systemic therapeutics targeting the peroxisome proliferator-activated receptors have been found to be beneficial in the treatment of diabetic retinopathy.
Treacy Maxwell P, Hurst Tara P
doaj +1 more source