Results 31 to 40 of about 248,501 (390)

The diabetes medication canagliflozin promotes mitochondrial remodelling of adipocyte via the AMPK-Sirt1-Pgc-1α signalling pathway

Adipocyte, 2020
The diabetes medication canagliflozin (Cana) is a sodium glucose cotransporter 2 (SGLT2) inhibitor acting by increasing urinary glucose excretion and thus reducing hyperglycaemia. Cana treatment also reduces body weight.
Xuping Yang, Qinhui Liu, Yanping Li, Qin Tang, Tong Wu, Lei Chen, Shiyun Pu, Yingnan Zhao, Guorong Zhang, Cuiyuan Huang, Jinhang Zhang, Zijing Zhang, Ya Huang, Min Zou, Xiongjie Shi, Wei Jiang, Rui Wang, Jinhan He   +17 more
doaj   +1 more source

Role of Esrrg in the Fibrate-Mediated Regulation of Lipid Metabolism Genes in Human ApoA-I Transgenic Mice [PDF]

, 2009
We have used a new ApoA-I transgenic mouse model to identify by global gene expression profiling, candidate genes that affect lipid and lipoprotein metabolism in response to fenofibrate treatment.
A Chroni, A Duka, A Patsialou, A Rigotti, A Walsh, AP Feinberg, B Staels, B Staels, B Staels, B Staels, B Staels, B Staels, BN Finck, CW Miller, D Arsenijevic, D Lan, D Sanoudou, D Sanoudou, D Sanoudou, EM Rubin, ES Cathcart, F Yadetie, G Fredrikson, G Martin, H Duez, H Samyn, HB Rubins, HY Kan, J Karbowska, J Lin, J St Pierre, JC Fruchart, JD Brunzell, JJ Lehman, JK Reddy, JL Goldstein, JM Huss, JM Huss, JP Desager, K C Hayes, K Drosatos, K Motojima, K Schoonjans, K Schoonjans, KE Kypreos, KE Kypreos, KS Frederiksen, L Berthou, LA Pennacchio, LJ Kelly, M Bouly, MB Eisen, MC Hunt, MJ Holness, N Hennuyer, N Vu-Dac, N Vu-Dac, N Vu-Dac, N Vu-Dac, NF Cariello, P Puigserver, Q Guo, R Sladek, RB Vega, RL Jacobs, SA Greenberg, SN Schreiber, V Beisvag, V Giguere, V I Zannis, V Litvak, VG Tusher, VI Zannis, VI Zannis, VI Zannis, WC Roberts, X Prieur, Y Kamei, Y Nagai, Z Wu   +79 more
core   +3 more sources

Complex coordination of cell plasticity by a PGC-1α-controlled transcriptional network in skeletal muscle [PDF]

, 2015
Skeletal muscle cells exhibit an enormous plastic capacity in order to adapt to external stimuli. Even though our overall understanding of the molecular mechanisms that underlie phenotypic changes in skeletal muscle cells remains poor, several factors ...
Agrawal, Aitchison, Altschul, Andersson, Blows, Blows, Bonduriansky, Brooks, Chenoweth, Chenoweth, Chung, Connallon, Coyne, Dallerac, Darwin, Doerge, Eyre-Walker, Fang, Ferreira, Ferveur, Fiumera, Frentiu, Gibbs, Gosden, Haldane, Hereford, Hine, Hine, Hine, Howard, Howard, Johnston, Kennington, Kingsolver, Kistler, Labeur, Lande, Long, Magwire, Mousseau, Park, Rako, Reinhart, Ritchie, Roff, Rundle, Sall, Siller, Swanson, Wagner, Weeks, Wilkinson, Zhang   +52 more
core   +4 more sources

Di(2-ethylhexyl) phthalate-induced toxicity and peroxisome proliferator-activated receptor alpha: a review

Environmental Health and Preventive Medicine, 2019
The plasticizer di(2-ethylhexyl) phthalate (DEHP) has been widely used in the manufacture of polyvinyl chloride-containing products such as medical and consumer goods.
Yuki Ito, M. Kamijima, T. Nakajima
semanticscholar   +1 more source

Peroxisome proliferator-activated receptor α-independent peroxisome proliferation [PDF]

Biochemical and Biophysical Research Communications, 2006
Hepatic peroxisome proliferation, increases in the numerical and volume density of peroxisomes, is believed to be closely related to peroxisome proliferator-activated receptor alpha (PPARalpha) activation; however, it remains unknown whether peroxisome proliferation depends absolutely on this activation.
Xiuguo, Zhang, Naoki, Tanaka, Takero, Nakajima, Yuji, Kamijo, Frank J, Gonzalez, Toshifumi, Aoyama   +5 more
openaire   +2 more sources

Peroxisome Proliferator-Activated Receptor-Targeted Therapies: Challenges upon Infectious Diseases

Cells, 2023
Peroxisome proliferator-activated receptors (PPARs) α, β, and γ are nuclear receptors that orchestrate the transcriptional regulation of genes involved in a variety of biological responses, such as energy metabolism and homeostasis, regulation of ...
In Soo Kim, Prashanta Silwal, Eun-Kyeong Jo   +2 more
doaj   +1 more source

Linking Induction and Transrepression of PPARβ/δ with Cellular Function [PDF]

, 2015
The copyrights of all papers published in this journal are retained by the respective authors as per the 'Creative Commons Attribution License' (http://creativecommons.org/licenses/by/3.0/).Peroxisome proliferator activated receptors (PPARs) are ligand ...
MacKenzie, Louise Susan, Perez Diaz, Noelia   +1 more
core   +3 more sources

Peroxisome Proliferator-Activated Receptor-γ Modulates the Response of Macrophages to Lipopolysaccharide and Glucocorticoids

Frontiers in Immunology, 2018
Although glucocorticoids (GC) represent the most frequently used immunosuppressive drugs, their effects are still not well understood. In our previous studies, we have shown that treatment of monocytes with GC does not cause a global suppression of ...
M. Heming, S. Gran, Saskia-L. Jauch, Lena Fischer-Riepe, A. Russo, L. Klotz, S. Hermann, M. Schäfers, J. Roth, K. Barczyk-Kahlert   +9 more
semanticscholar   +1 more source

Role of Peroxisome Proliferator-Activated Receptor α in Diabetic Nephropathy [PDF]

Diabetes & Metabolism Journal, 2011
With a developing worldwide epidemic of diabetes mellitus, the renal complications associated with diabetes have become a serious health concern. Primary therapy for treating diabetic nephropathy is a multifactorial process.
Sungjin Chung, Cheol Whee Park
doaj   +1 more source

Modulation of PGC-1α activity as a treatment for metabolic and muscle-related diseases [PDF]

, 2014
Physical inactivity is a predisposing factor for various disease states including obesity, cardiovascular disease, as well as for certain types of cancer. Regular endurance exercise mediates several beneficial effects such as increased energy expenditure
Handschin, Christoph, Svensson, Kristoffer   +1 more
core   +1 more source