Results 91 to 100 of about 103,678 (289)
PPAR Research, 2008 Peroxisome proliferator-activated receptors (PPARs) are transcriptional factors involved in the regulation of insulin resistance and adipogenesis. Cinnamon, a widely used spice in food preparation and traditional antidiabetic remedy, is found to activate
Xiaoyan Sheng +4 more
doaj +1 more source
Peroxisome Proliferator-Activated Receptors (PPARS)
THE JOURNAL OF MICROBIOLOGY AND MOLECULAR GENETICS, 2020 Peroxisome proliferator-activated receptors are a group (PPARs) of transcription factors whose differential distribution in different tissues, including adipocytes, hepatocytes, musclesand endothelial cells lead to different clinical outcomes. They are called lipid and insulin sensors due to the important role in lipid and glucose homeostasis. They are
null Sumbal Sarwar, null Shabana
openaire +2 more sources
Advanced Science, EarlyView.ABSTRACT Engineered ascorbate peroxidase APEX2 has been widely used for spatially restricted profiling of subcellular biomolecules, but its catalytic efficiency toward newly developed probes such as biotin‐aniline (Btn‐An) remains suboptimal. To overcome this limitation, we performed yeast surface display‐based directed evolution to enhance APEX2 ...
Gang Wang, Yi Li, Peiyuan Meng, Peng Zou
wiley +1 more source
The Role of PPARgamma in the Cyclooxygenase Pathway in Lung Cancer. [PDF]
, 2008 Decreased expression of peroxisome proliferator activated receptor-gamma (PPARgamma) and high levels of the proinflammatory enzyme cyclooxygenase-2 (COX-2) have been observed in many tumor types.
Dubinett, Steven M +4 more
core
Zebrafish as a model to study the role of Peroxisome Proliferating-Activated Receptors in adipogenesis and obesity [PDF]
, 2015 The Peroxisome Proliferator-Activated Receptors (PPARs) PPARA and PPARD are regulators of lipid metabolism with important roles in energy release through lipid breakdown, while PPARG plays a key role in lipid storage and adipogenesis.
Den Broeder, MJ +3 more
core +5 more sources
Advanced Science, EarlyView.SETD1A is a key epigenetic regulator in NPCs during IDD. In normal NPCs, it sustains H3K4me3–HELZ2/PPARα–HIF1α signaling to maintain glycolytic energy metabolism and proliferation. In degenerated NPCs, reduced SETD1A disrupts this axis, impairing glycolysis and accelerating senescence, highlighting a promising therapeutic target for IDD.
Jiawei Fu +11 more
wiley +1 more source
The role of platelet microvesicles in intercellular communication. [PDF]
, 2016 In recent years, there has been exponential growth in the interest in microvesicles, which is reflected by the number of publications. Initially referred to as platelet dust by Peter Wolf in 1967, platelet microvesicles (PMV) are now recognized as ...
Edelstein, Leonard C.
core +2 more sources
Advanced Science, EarlyView.After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng +9 more
wiley +1 more source
Altered Peroxisome-Proliferator Activated Receptors Expression in Human Endometrial Cancer
PPAR Research, 2012 Peroxisome proliferator-activated receptors (PPARs) belong to a family of nuclear hormone receptors acting as transcriptional factors, recently involved also in carcinogenesis.
Paweł Knapp +4 more
doaj +1 more source
Childhood Obesity and Familial Hypercholesterolemia: Genetic Diseases that Contribute to Cardiovascular Disease [PDF]
, 2014 Childhood obesity occurs as the result of an imbalance between caloric intake and energy expenditure. Genetic risk factors for obesity have become an area of research due to its permanency.
Caudle, Alyssa
core +1 more source