Results 101 to 110 of about 1,310,860 (245)

Anti-Diabetic Effect of Telmisartan Through its Partial PPARγ-Agonistic Activity

Diabetes, Metabolic Syndrome and Obesity, 2020
Muluken Altaye Ayza, Kaleab Alemayehu Zewdie, Bekalu Amare Tesfaye, Selamawit Tesfamariam Gebrekirstos, Derbew Fikadu Berhe Department of Pharmacology and Toxicology, School of Pharmacy, Mekelle University, Mekelle, EthiopiaCorrespondence: Muluken Altaye
Ayza MA, Zewdie KA, Tesfaye BA, Gebrekirstos ST, Berhe DF   +4 more
doaj  

Regulation of fish metabolism by peroxisome proliferator-activated receptor

Siliao yanjiu, 2023
Peroxisome proliferator activated receptors (PPARs) are ligands activated receptors of the nuclear hormone receptor family, and PPARs are important for carbohydrate and lipid metabolism, cell differentiation, embryonic development, adipogenesis and other
LIU Xin, SUN Shu-qian, ZHAO Yan-cui, LI Ming-zhu   +3 more
doaj  

The role of the coactivators PGC-1α and PGC-1β in retina and skeletal muscle [PDF]

, 2011
Peroxisome proliferator-activated receptor γ coactivator- 1 (PGC-1) designates a family of coactivators consisting of PGC-1α, PGC-1β and PRC. By associating with transcription factors like nuclear receptors, they induce transcription of target genes that
Egger, A, Egger, Anna Franziska
core   +1 more source

T‐Cell Remodeling in Renal Fibrosis: From Acute Injury to Chronic Kidney Disease

Advanced Science, EarlyView.
This Review presents renal fibrosis as a sequence of overlapping T‐cell programs, from chemokine‐guided recruitment and metabolic activation to maladaptive polarization, tertiary lymphoid structure formation, tissue residency, exhaustion, and senescence.
Qianhui Li, Junting Guan, Yifan Song, Hongxia Yang, Guangtao Li, Xiaodong Zhao, Jiaxin Liu, Bin Liu, Yang Tan, Honglan Zhou, Yang‐He Zhang, Yishu Wang   +11 more
wiley   +1 more source

Magnetoreceptor Promotes Hepatocellular Carcinoma Development and Blunts Sorafenib‐Induced Ferroptosis by Regulating Iron Homeostasis

Advanced Science, EarlyView.
Magnetoreceptor (MagR) regulates iron homeostasis and mitochondrial function in hepatocellular carcinoma (HCC) cells. Specifically, MagR deficiency suppresses tumor cell proliferation, migration, and invasion and enhances sorafenib‐induced ferroptosis through iron accumulation.
Tao Wang, Chenghua Song, Xin He, Mengzhou Wang, Wuming Liu, Xiaolin Wang, Yuanyuan Zhang, Jia Zhang, Lin Zhang, Dan Li, Yu Zhang, Zheng Wu, Yi Lyu, Rongqian Wu   +13 more
wiley   +1 more source

Intestinal peroxisome proliferator‐activated receptor α‐fatty acid‐binding protein 1 axis modulates nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Abstract Background and Aims Peroxisome proliferator‐activated receptor α (PPARα) regulates fatty acid transport and catabolism in liver. However, the role of intestinal PPARα in lipid homeostasis is largely unknown. Here, intestinal PPARα was examined for its modulation of obesity and NASH. Approach and Results Intestinal PPARα was activated and fatty
Tingting Yan, Yuhong Luo, Nana Yan, Keisuke Hamada, Nan Zhao, Yangliu Xia, Ping Wang, Changdong Zhao, Dan Qi, Shoumei Yang, Lulu Sun, Jie Cai, Qiong Wang, Changtao Jiang, Oksana Gavrilova, Kristopher W. Krausz, Daxesh P. Patel, Xiaoting Yu, Xuan Wu, Haiping Hao, Weiwei Liu, Aijuan Qu, Frank J. Gonzalez   +22 more
wiley   +1 more source

NCOA4 Accelerates Abdominal Aortic Aneurysm Formation by Regulating Macrophage Activation and Ferroptosis via STAT1–CH25H Axis

Advanced Science, EarlyView.
Under pathological stimulation, NCOA4 in macrophages interacts with STAT1 to promote CH25H transcription. The subsequent increase in 25‐HC production activates macrophages, triggers inflammatory responses and ferroptosis, and accelerates the progression of AAA.
Zhinan Wu, Yuxuan Qian, Wenyi Xu, Fei Liao, Xueliang Liu, Xiao Kuang, Guqing Luo, Xinjie He, Lixian Jiang, Song Ding   +9 more
wiley   +1 more source

NAFLD‐related hepatocellular carcinoma: The growing challenge

Hepatology, EarlyView., 2022
Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah, Rashmee Patil, Stephen A. Harrison   +2 more
wiley   +1 more source

Leptin and peroxisome proliferator activated receptor alpha: understanding their contribution towards normalising the programmed phenotype in the peripheral tissues of IUGR offspring

, 2010
In a rat model of intrauterine growth restriction (IUGR) induced by maternal global undernutrition, adult offspring are obese with associated metabolic disturbances. These metabolic abnormalities are all augmented by feeding a high calorie postnatal diet
Garratt, Emma
core   +1 more source

Peroxisome Proliferator-Activated Receptors and Hepatitis C Virus-Induced Insulin Resistance

PPAR Research, 2009
Insulin resistance and type 2 diabetes are associated with hepatitis C virus infection. A wealth of clinical and experimental data suggests that the virus is directly interfering with the insulin signalling in hepatocytes.
Francesco Negro
doaj   +1 more source