Results 101 to 110 of about 103,678 (289)

Transcriptional Regulation of T-Cell Lipid Metabolism: Implications for Plasma Membrane Lipid Rafts and T-Cell Function [PDF]

, 2017
It is well established that cholesterol and glycosphingolipids are enriched in the plasma membrane (PM) and form signalling platforms called lipid rafts, essential for T-cell activation and function.
Adlanmerini, Aktas, al Yacoub, Araldi, Ashdown, Balamuth, Bensinger, Bovenga, Brown, Burridge, Chaudhri, Cho, Clark, Daniel, Degroote, Della Torre, Dimeloe, Dunn, Fievet, Foryst-Ludwig, Fox, Gaudet, Gervois, Greenwood, Griffié, Guo, Harris, Herold, Horton, Hughes, Ifergan, Iida, Ikonen, Ishikawa, Ito, Janes, Jeong, Jones, Jury, Jury, Jury, Kanakasabai, Keller, Kidani, Kidani, Kidani, Kirchgessner, Kishimoto, Klein, Kosters, Köberlin, Lappano, Lee, Levental, Levental, Levin, Lingwood, Lisse, Lovett-Racke, Lund, Luquet, Magee, McDonald, Megha, Mesmin, Miguel, Molnár, Nagafuku, Nazarov-Stoica, Ngo, Nuñez, Oliver, Owen, Owen, Pelekanou, Phiel, Quinet, Radhakrishnan, Repa, Rong, Rubin-Delanchy, Sankaran-Walters, Simigdala, Simons, Spann, Steffensen, Sun, Svenson, Swamy, Swinnen, Tang, Tcherepanova, Thangavel, Uppal, Uppal, Varga, Waddington, Waddington, Walcher, Wang, Wang, Wang, Wang, Wang, Wu, Yang, Youssef, Zalba, Zelcer, Zhu   +109 more
core   +2 more sources

Descriptive Epidemiology From the Myhre Syndrome Foundation Registry: The Value of Self‐Reported Data

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre syndrome is an ultrarare genetic disease characterized by short stature, distinct craniofacial features, cardiovascular and respiratory fibrosis and stenosis, neurodevelopmental delays, autism, intellectual disability, and hearing loss. The natural history of Myhre syndrome is still not fully understood due to a small patient population ...
Mary K. Young, Armelle Pindon, Maggie R. Brand, Kate Wears, Katherine H. Young, Alyssa Mendel, Michael J. Lyons   +6 more
wiley   +1 more source

Peroxisome Proliferator-Activated Receptors Associated with Nonalcoholic Fatty Liver Disease

PPAR Research, 2017
Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming a major cause of chronic liver disease worldwide. Concurrent to an increase in NAFLD prevalence, there is an increase in the obesity epidemic and the correlated insulin-resistant state. It is a
Nan Wang, Rui Kong, Hui Luo, Xiaorong Xu, Jie Lu   +4 more
doaj   +1 more source

The Role of Peroxisome Proliferator-Activated Receptors (PPARs) in Pan-Cancer

PPAR Research, 2020
Peroxisome proliferator-activated receptors (PPARs) are members of nuclear transcription factors. The functions of the PPAR family (PPARA, PPARD, and PPARG) and their coactivators (PPARGC1A and PPARGC1B) in maintenance of lipid and glucose homeostasis ...
Runzhi Huang, Jiaqi Zhang, Mingxiao Li, Penghui Yan, Huabin Yin, Suna Zhai, Xiaolong Zhu, Peng Hu, Jiaxin Zhang, Ling Huang, Man Li, Zehui Sun, Tong Meng, Daoke Yang, Zongqiang Huang   +14 more
doaj   +1 more source

Nuclear receptors in vascular biology [PDF]

, 2015
Nuclear receptors sense a wide range of steroids and hormones (estrogens, progesterone, androgens, glucocorticoid, and mineralocorticoid), vitamins (A and D), lipid metabolites, carbohydrates, and xenobiotics.
A Chawla, A McCurley, AA Hamers, AL Bookout, B Fisslthaler, BG Hoebel, C McCarthy, C Zhou, CH Lee, CK Glass, CK Huang, CT Lee, D Bishop-Bailey, D Bishop-Bailey, David Bishop-Bailey, DP Edwards, E Gerlach, F Akbiyik, FA Pereira, FL Wynne, FY Ali, G Pascual, I Dussault, I Spoletini, J He, J Qin, J Sonoda, J Xiang, K Spruiell, KE Swales, L Calza, L Li, L Piqueras, LA Moraes, LA Moraes, LJ Jonk, LR You, M Kaushik, M Matic, N Albermann, N Schafer, N Takamoto, Q Qin, R Zhao, S Asgary, S Chakrabarti, S Marino De, S Stein, SA Kliewer, V Zoete, W El-Sankary, WC Lau, X Wang, Y Ma, Y Sui, Y Sui, YW Hu   +56 more
core   +3 more sources

Unveiling a New Link: Cholesterol Deficiency in Smith–Lemli–Opitz and Niemann–Pick C as a Driver of Ciliopathies

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The ciliopathies are a group of genetic disorders caused by defective function of either the primary cilia (a large number) or the motile cilia (a much smaller number). These have been defined as diseases with mutations in genes encoding individual ciliary or cilia‐associated proteins.
Robert P. Erickson, Maria Teresa Fiorenza   +1 more
wiley   +1 more source

Regulation of Peroxisome Proliferator-Activated Receptors by E6-Associated Protein

PPAR Research, 2008
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors (NRs) that regulate genes involved in lipid and glucose metabolism. PPAR activity is regulated by interactions with cofactors and of interest are cofactors with ubiquitin ligase ...
Lakshmi Gopinathan, Daniel B. Hannon, Russell W. Smith, Jeffrey M. Peters, John P. Vanden Heuvel   +4 more
doaj   +1 more source

Nuclear Receptors as Targets for Drug Development: Peroxisome Proliferator-Activated Receptor γ in Mast Cells: Its Roles in Proliferation and Differentiation

Journal of Pharmacological Sciences, 2005
Mast cells are derived from stem cells in bone marrow and their proliferation and differentiation are regulated by stimulation of stem cell factor derived from fibroblasts and/or IL-3 from T lymphocytes.
Kazutaka Maeyama, Maiko Emi, Masashi Tachibana   +2 more
doaj   +1 more source

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18:Nuclear hormone receptors [PDF]

, 2017
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and ...
,, Alexander, Stephen Ph, Cidlowski, John A, Davies, Jamie A, Faccenda, Elena, Harding, Simon D, Kelly, Eamonn, Marrion, Neil V, Pawson, Adam J, Peters, John A, Sharman, Joanna L, Southan, Christopher   +11 more
core   +5 more sources

Tree shrew model of early diabetic retinopathy reveals microvascular dysfunction and identifies phosphoserine aminotransferase 1 as a novel therapeutic target

Animal Models and Experimental Medicine, EarlyView.
We developed an animal model of early diabetic retinopathy (DR) in the tree shrew by feeding a high‐fat and high‐sugar diet in combination with STZ. Physiological and biochemical index detection, hematoxylin and eosin staining, and transmission electron microscopy were performed to examine DR.
Min Qiu, Shurui Huo, Wenguang Wang, Na Li, Qingwei Zeng, Xiaomei Sun, Jiejie Dai, Pinfen Tong, Yuanyuan Han, Ling Zhao, Caixia Lu   +10 more
wiley   +1 more source