Results 81 to 90 of about 1,310,860 (245)
Altered Peroxisome-Proliferator Activated Receptors Expression in Human Endometrial Cancer
PPAR Research, 2012 Peroxisome proliferator-activated receptors (PPARs) belong to a family of nuclear hormone receptors acting as transcriptional factors, recently involved also in carcinogenesis.
Paweł Knapp +4 more
doaj +1 more source
Kern-basierte Lernverfahren für das virtuelle Screening [PDF]
, 2010 We investigate the utility of modern kernel-based machine learning methods for ligand-based virtual screening. In particular, we introduce a new graph kernel based on iterative graph similarity and optimal assignments, apply kernel principle component ...
Rupp, Matthias
core
Advanced Science, EarlyView.The SIRT5/ACAA2 axis maintains lipid metabolic homeostasis in RTECs by promoting ACAA2 desuccinylation and preserving its stability and enzymatic activity, thereby sustaining FAO and limiting PUFA and PUFA‐containing phospholipid accumulation. Under CaOx stress, SIRT5 downregulation impairs FAO, promotes oxidative stress and ferroptosis, and enhances ...
Qinhong Jiang +6 more
wiley +1 more source
Advanced Science, EarlyView.This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su +9 more
wiley +1 more source
Peroxisome Proliferator-Activated Receptors Associated with Nonalcoholic Fatty Liver Disease
PPAR Research, 2017 Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming a major cause of chronic liver disease worldwide. Concurrent to an increase in NAFLD prevalence, there is an increase in the obesity epidemic and the correlated insulin-resistant state. It is a
Nan Wang +4 more
doaj +1 more source
Journal of Pharmacological Sciences, 2005 Mast cells are derived from stem cells in bone marrow and their proliferation and differentiation are regulated by stimulation of stem cell factor derived from fibroblasts and/or IL-3 from T lymphocytes.
Kazutaka Maeyama +2 more
doaj +1 more source
The Role of Peroxisome Proliferator-Activated Receptors (PPARs) in Pan-Cancer
PPAR Research, 2020 Peroxisome proliferator-activated receptors (PPARs) are members of nuclear transcription factors. The functions of the PPAR family (PPARA, PPARD, and PPARG) and their coactivators (PPARGC1A and PPARGC1B) in maintenance of lipid and glucose homeostasis ...
Runzhi Huang +14 more
doaj +1 more source
Multi‐Tissue Crosstalk Regulating Meniscus Healing Under Inflammation and Physiological Loading
Advanced Science, EarlyView.Using a novel Meniscus‐on‐a‐chip (MoC) model integrated with a meniscus‐specific bioreactor, this study investigated the roles of multi‐tissue crosstalk that regulates injury, healing, and degeneration of the meniscus injury under inflammation and pathophysiological loading.
Hun Jin Jeong +5 more
wiley +1 more source
Regulation of Peroxisome Proliferator-Activated Receptors by E6-Associated Protein
PPAR Research, 2008 Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors (NRs) that regulate genes involved in lipid and glucose metabolism. PPAR activity is regulated by interactions with cofactors and of interest are cofactors with ubiquitin ligase ...
Lakshmi Gopinathan +4 more
doaj +1 more source
Fibrates, glitazones, and peroxisome proliferator-activated receptors.
, 2010 International audienceSeveral decades ago, fibrates were approved for the treatment of dyslipidemia, whereas thiazolidinediones were screened in animal models to improve glucose homeostasis and were subsequently developed for the treatment of type 2 ...
Staels, Bart, Lalloyer, Fanny
core +1 more source