Results 81 to 90 of about 103,678 (289)

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

Recent Trends in Metabolomics by NMR Spectroscopy

Angewandte Chemie, EarlyView.
AI tools were applied to analyze more than 5 000 publications indexed in Scopus (2018–2025), identifying key trends and research directions in NMR‐based metabolomics. The artificial intelligence‐assisted workflow classified papers into six main fields of application, human health, food and nutrition, veterinary science, plants, environment, and ...
Giorgio Di Paco, Gaia Meoni, Veronica Ghini, Alessia Vignoli, Leonardo Tenori, Paola Turano, Claudio Luchinat   +6 more
wiley   +2 more sources

Gut Microbiota, Peroxisome Proliferator-Activated Receptors, and Hepatocellular Carcinoma

Journal of Hepatocellular Carcinoma, 2020
Qiang Yu,1,2 Liwei Wu,2 Jie Ji,2 Jiao Feng,2 Weiqi Dai,1– 3 Jingjing Li,1,2 Jianye Wu,1 Chuanyong Guo1,2 1Department of Gastroenterology, Putuo People’s Hospital, Tongji University School of Medicine, Shanghai 200060, People’s Republic ...
Yu Q, Wu L, Ji J, Feng J, Dai W, Li J, Wu J, Guo C   +7 more
doaj  

The Role of Peroxisome Proliferator-Activated Receptors in Colorectal Cancer

PPAR Research, 2012
Colorectal cancer is one of the most common cancers in the world. Dietary fat intake is a major risk factor for colorectal cancer. Some nuclear hormone receptors play an important role in regulating nutrient metabolism and energy homeostasis. Among these
Joo-In Park, Jong-Young Kwak
doaj   +1 more source

Peroxisome Proliferator-Activated Receptor–α [PDF]

Hypertension, 2007
The quest for better understanding for the pathophysiological basis of hypertension and atherosclerosis is ongoing. The complexity of hypertension and atherosclerosis and of the underlying mechanisms is becoming increasingly apparent. The number of candidate genes and molecular pathways that are involved is increasing in parallel.
Chana Yagil, Yoram Yagil
openaire   +1 more source

Peroxisome proliferator-activated receptor (PPAR)alpha expression in T cells mediates gender differences in development of T cell-mediated autoimmunity. [PDF]

, 2007
Peroxisome proliferator-activated receptor (PPAR)alpha is a nuclear receptor that mediates gender differences in lipid metabolism. PPARalpha also functions to control inflammatory responses by repressing the activity of nuclear factor kappaB (NF-kappaB ...
Baranzini, Sergio E, Crowell, Andrea, Dunn, Shannon E, Loh, John, Oksenberg, Jorge, Ousman, Shalina S, Sobel, Raymond A, Steinman, Lawrence, Youssef, Sawsan, Zuniga, Luis   +9 more
core  

Utilizing small nutrient compounds as enhancers of exercise-induced mitochondrial biogenesis. [PDF]

, 2015
Endurance exercise, when performed regularly as part of a training program, leads to increases in whole-body and skeletal muscle-specific oxidative capacity.
Acheson, Achten, Alemo Munters, Alexander, Andersen, Atherton, Baar, Baggish, Bartlett, Bartlett, Bassett, Beere, Bonen, Bonne, Boon, Bosselaar, Bravo, Bruckbauer, Buijsse, Cantó, Carey, Chen, Chong, Coggan, Crowe, Crowe, Cureton, Cuthbertson, D'Antona, Davis, Davis, Dominy, Dorta, Dulloo, Dulloo, Dumke, Egawa, Egawa, Eid, Fan, Ferketich, Fitts, Ganio, Gibala, Gliemann, Gollnick, Goodyear, Graham, Green, Gualano, Gutiérrez-Salmeán, Hagberg, Harms, Hasler, Hawley, Hawley, Hodgson, Holloszy, Holloszy, Holloszy, Hoppeler, Howitz, Hüttemann, Ingjer, Ivy, Jones, Jung, Kalliokoski, Karlsson, Klausen, Koivisto, Labayen, Lee, Liang, Lin, Little, Lluís, López-Lluch, MacMahon, Martínez-Redondo, Matsakas, Maughan, Merrill, Molé, Montero, Moore, Moore, Morris, Murase, Murase, Murias, Murias, Narkar, Nieman, Nogueira, Olesen, Oscai, Ota, Park, Perez-Schindler, Philp, Pogozelski, Puigserver, Putman, Raben, Randell, Randell, Richter, Sahebkar, Saleem, Saltin, Saltin, Saltin, Saltin, Sawka, Scribbans, Shimotoyodome, Siemann, Simoneau, Smith, Spangenburg, Spina, Spina, Steinberg, Suchankova, Sun, Venables, Wang, White, Winder, Wright, Wright, Yan, Youn, Zhu   +134 more
core   +5 more sources

Cars2‐Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2

Advanced Science, EarlyView.
We demonstrate that Cars2, a cysteine catabolic enzyme in mouse iBAT, is critical for cold tolerance and brown adipocyte differentiation. Through its CPERS activity, Cars2 produces CysSSH/H2S to induce EBF2 persulfidation, promoting its interaction with PPARγ and BRG1 to enhance thermogenic gene expression.
Xin Peng, Hongyong Song, Yin Long, Kaimin Wu, Yinkun Fu, Wenkai Zhou, Wenyan Li, Zhe Shi, Xu‐Yun Zhao   +8 more
wiley   +1 more source

Dietary moderately oxidized oil induces expression of fibroblast growth factor 21 in the liver of pigs [PDF]

, 2012
BACKGROUND: Fibroblast growth factor 21 (FGF21), whose expression is induced by peroxisome proliferator-activated receptor alpha (PPARalpha), has been recently identified as a novel metabolic regulator which plays a crucial role in glucose homeostasis ...
Eder, Klaus, Ringseis, Robert, Varady, Juliane   +2 more
core   +2 more sources

Multi‐Omics Insights Into the Mechanisms of Early Muscle Fiber Difference and Transformation Between Lean‐Type and Chinese Indigenous Pigs

Advanced Science, EarlyView.
Multi‐omics analyses uncover breed‐specific cis‐regulatory landscapes and higher‐order chromatin architectural differences that underlie early postnatal muscle fiber divergence in pigs. A super‐enhancer upstream of PPP3CB recruits MEF2C to activate PPP3CB transcription, while the PPP3CB–MEF2C positive feedback loop promotes oxidative muscle fiber ...
Shuailong Zheng, Hainan Wu, Min Liu, Kunpeng Wu, Shuntao Huang, Zulfiqar Ahmed, Lenox Pius, Mengjin Zhu, Dequan Xu   +8 more
wiley   +1 more source