Results 211 to 220 of about 53,252 (304)

Remodeling of Metabolic and Secretory Organelles During Oncogenic and Oncomodulatory Viral Infections. [PDF]

Viruses
Rodriguez W, Cristea IM.
europepmc   +1 more source

Putative involvement of lncRNA, miRNA, and mRNA‐mediated ceRNA network regulation in drought priming to enhance drought tolerance in Nicotiana tabacum

Annals of Applied Biology, EarlyView.
Drought priming increased the tolerance of Nicotiana tabacum to severe, recurring drought stress by modulating the expression of stress‐related genes via long non‐coding RNAs (lncRNAs), which acted as competing endogenous RNAs (ceRNAs) for microRNAs (miRNAs) and messenger RNAs (mRNAs).
Fatma Aydinoglu, Elif Yalvac
wiley   +1 more source

Aging-related peroxisomal dysregulation disrupts intestinal stem cell differentiation through alterations of very long-chain fatty acid oxidation. [PDF]

PLoS Biol
Guo X, Du G, Zhou J, Fu F, Yuan Y, Liu X, Chen H, Wan Q, Gong B, Chen H.   +9 more
europepmc   +1 more source

Characterization of Human Group 9 Innate Lymphoid Cells in Response to Allergen Immunotherapy in Patients With Allergic Rhinitis

Allergy, EarlyView.
We aimed to report the existence and profile of group 9 innate lymphoid cells (ILC9s). Overall, ILC9 proportions in AR patients show differences compared to healthy subjects and responder SCIT patients. IL‐9 expression decreases after siRNA inhibition of Bach2 suggesting Bach2 could display as a transcription factor of ILC9.
Ya‐Qi Peng, Te Zhang, Xiao‐Qing Liu, Ismail Ogulur, Qi Sun, Beate Ruckert, Bi‐Xin He, De‐Hua Chen, Hideaki Morita, Hui‐Jing Ye, Qing‐Ling Fu, Cezmi A. Akdis   +11 more
wiley   +1 more source

Mitochondria-Derived Vesicles and Mitochondrial Extracellular Vesicles in Health and Cardiovascular Disease. [PDF]

Circ Res
Rapushi E, Aryal A, Yang T, Li Z, Wang X, Fan GC.   +5 more
europepmc   +1 more source

Seladelpar Improved Itch, Itch‐Related Sleep Disturbance and Measures of Fatigue in Patients With Primary Biliary Cholangitis and Pruritus in the Phase 3 RESPONSE Trial

Alimentary Pharmacology &Therapeutics, EarlyView.
Seladelpar improved itch, itch‐related sleep disturbance and measures of fatigue in patients with primary biliary cholangitis and pruritus in the Phase 3 RESPONSE trial. ABSTRACT Background Pruritus and fatigue impose a significant burden on patient quality of life in primary biliary cholangitis (PBC).
Cynthia Levy, David E. J. Jones, Marlyn J. Mayo, Christopher L. Bowlus, Kris V. Kowdley, Gideon M. Hirschfield, Jie Liu, Caroline Burk, Susheela Carroll, Daria B. Crittenden, Andreas E. Kremer   +10 more
wiley   +1 more source

PEDV NSP8 inhibits IFN-III production induced by MAVS through downregulation of PEX13. [PDF]

mBio
Lou J, Zhu H, Yang Z, Jiang P, Liu G, Wang X.   +5 more
europepmc   +1 more source

A Nationwide Assessment of Anticholestatic Therapy Uptake in Patients With Primary Biliary Cholangitis: Opportunities for Optimisation

Alimentary Pharmacology &Therapeutics, EarlyView.
Among a nationwide population with primary biliary cholangitis, almost all people were prescribed ursodeoxycholic acid (UDCA). However, UDCA was insufficiently dosed in a one third of them. The results indicate that first‐line treatment can be optimized, particularly in those with a biochemical response and higher body weight.
Ellen Werner, Maria C. B. van Hooff, Gemma H. X. Weijsters, Maria A. van de Vrie, Rozanne C. de Veer, Ulrich Beuers, Joost P. H. Drenth, Frans J. C. Cuperus, Remco van Dijk, Bart J. Veldt, Michael Klemt‐Kropp, Suzanne van Meer, Robert C. Verdonk, Hajo J. Flink, Jan Maarten Vrolijk, Matthijs Kramer, Cyriel Y. Ponsioen, Kirsten Boonstra, Femke Boersma, Hendrik J. M. de Jonge, Frank H. J. Wolfhagen, L. C. Baak, Susanne L. Onderwater, Jeroen D. van Bergeijk, Paul G. van Putten, Gijs J. de Bruin, Rob P. R. Adang, Maria N. Aparicio‐Pages, Wink de Boer, Frank ter Borg, Hanneke van Soest, Elsemieke S. de Vries, Nicole S. Erler, Bettina E. Hansen, Harry L. A. Janssen, Adriaan J. van der Meer, on behalf of the Dutch PBC Study Group, Adriaan J. van der Meer, Anne Vrieze, A. (Sander) van der Beek, Bart J. Veldt, Bart van Hoek, Bettina E. Hansen, Cyriel Y. Ponsioen, Daphne M. Hotho, Djuna L. Cahen, Edith M.M. Kuiper, Ellen Werner, Elsemieke de Vries, Femke Boersma, Frank C. Bekkering, Frank H.J. Wolfhagen, Frank ter Borg, Frans J.C. Cuperus, Gemma X. Weijsters, Gijs J. de Bruin, Hajo J. Flink, Hanneke van Soest, Hans H.K. Thio, Harry L.A. Janssen, Hendrik J.M. de Jonge, Huseyin Aktas, Ingrid C.A.W. Konings, J. Marleen de Vree, J. (Netty) van Kemenade, Jan Maarten Vrolijk, Janne E. van Rooij, Jeroen D. van Bergeijk, Jerome Sint Nicolaas, Johan P.H. Kuyvenhoven, Johannes Schmidt‐Böhmer, Joost P.H. Drenth, Khalida Soufidi, Kirsten Boonstra, Laurens A. van der Waaij, L. (Bert) C. Baak, Leendert H. Oterdoom, Lisette J.H. van Dam, Ludger S.M. Epping, Paul J. Bus, Maaike J. Denters, Marcel Cazemier, Maria C. van Hooff, Maria N. Aparicio‐Pages, Marjo J. Kerbert‐Dreteler, Martijn J. ter Borg, Martine A.M.C. Baven‐Pronk, Matthias C. Jurgens, Matthijs Kramer, Menno Beukema, Merel M. Tielemans, Michael Klemt‐Kropp, Nicole F.M. van Gerven, Nicole S. Erler, Paul G. van Putten, Philip W. Friederich, Pieter C.J. ter Borg, Robert C. Verdonk, Remco van Dijk, Rob P.R. Adang, Robert Roomer, Rozanne C. de Veer, Sander de Kort, Sigrid Vandebosch, Stephan H.C. van Stiphout, Stephan Schmittgens, Sunje Abraham, Susanne L. Onderwater, Suzanne van Meer, Sven J. van den Hazel, Tiki D. Blom, Tim C.M.A. Schreuder, Tom J.G. Gevers, Ulrich Beuers, Ulrike de Wit, Wink de Boer, Yasser A. Alderlieste   +116 more
wiley   +1 more source

Odd-Chain Dicarboxylic Acid Feeding Produces a Glutaric Aciduria Type 1-Like Metabolic Signature in Mice. [PDF]

FASEB J
Richert AC, Zhang Y, Bharathi SS, Hernandez A, Dodatko T, Bons J, Roundtree KE, Stauffer B, Yu C, Schilling B, Houten SM, Goetzman ES.   +11 more
europepmc   +1 more source

A multicentre analysis of efficacy, safety and molecular response correlates of fostamatinib in warm autoimmune haemolytic anaemia and Evans syndrome

British Journal of Haematology, EarlyView.
Fostamatinib had 46% durable response, with 73% steroid reduction, in this multicentre retrospective study of refractory wAIHA/ES. Hypertension, gastrointestinal (GI) distress and neutropenia occurred in 23%. Only one patient required drug discontinuation and one patient dose reduction.
Jorge N. Ruiz Lopez, Lipei Shao, Debbie Jiang, Lawrence S. Bailey, Thejaswi Bikkani, Aaron Boothby, Donald C. Moore, Irina Murakhovskaya, Caroline I. Piatek, Mauricio Pineda‐Roman, Ping Jin, Jacqueline N. Poston, Moritz Stolla, David F. Stroncek, Krystalyn E. Hudson, James B. Bussel, Sandhya R. Panch   +16 more
wiley   +1 more source