Results 111 to 120 of about 76,980 (312)

Biomarkers for the estimation of isoproterenol‐induced myocardial infarction: A review of key parameters

Journal of Intelligent Medicine, EarlyView.
Abstract The isoproterenol‐induced myocardial infarction model is a well‐established experimental approach for studying cardiac injury and testing potential protective treatments. By overstimulating beta‐adrenergic receptors, this model closely reproduces key features of human heart attacks, including oxidative damage, calcium imbalance, inflammatory ...
Bushra Imran, Tarique Mahmood, Farogh Ahsan, Shahzadi Bano, Vaseem Ahamad Ansari, Mohd Adnan   +5 more
wiley   +1 more source

Nitrostative stress status during seasonal and pdmH1N1 infection in Iraq

Journal of Infection in Developing Countries, 2011
Introduction: Influenza A virus infection is associated with oxidative and nitrosative stress. This study aimed to assess nitrosative stress in pandemic H1N1 (pdmH1N1) and seasonal influenza A infected patients.
Marwan S. M. Al-Nimer, Majid M Mahmood, Saba Saadoon Khazaal   +2 more
doaj   +1 more source

The role of peroxiredoxins in cancer [PDF]

, 2017
Peroxiredoxins (PRDXs) are a ubiquitously expressed family of small (22-27 kDa) non-seleno peroxidases that catalyze the peroxide reduction of H2O2, organic hydroperoxides and peroxynitrite.
CAPALBO, CARLO, COPPA, Anna, D'INZEO, SONIA, GIANNINI, Giuseppe, NICOLUSSI, Arianna   +4 more
core   +1 more source

Effects of catechins, resveratrol, silymarin components and some of their conjugates on xanthine oxidase‐catalyzed xanthine and 6‐mercaptopurine oxidation

Journal of the Science of Food and Agriculture, Volume 105, Issue 5, Page 2765-2776, 30 March 2025.
Abstract BACKGROUND Over the past two decades, the global incidence of gout has markedly increased, affecting people worldwide. Considering the side effects of xanthine oxidase (XO) inhibitor drugs (e.g. allopurinol and febuxostat) used in the treatment of hyperuricemia and gout, the potential application of phytochemicals has been widely studied.
Tímea Bencsik, Orsolya Balázs, Róbert G Vida, Balázs Z Zsidó, Csaba Hetényi, Kateřina Valentová, Miklós Poór   +6 more
wiley   +1 more source

Diffusion of peroxynitrite, its precursors, and derived reactive species, and the effect of cell membranes

Redox Biochemistry and Chemistry
Peroxynitrite is a powerful oxidant formed in vivo in sites where superoxide and nitric oxide coincide. Peroxynitrite is cytotoxic through oxidative modification of target biomolecules that can occur by direct or indirect reactions.
Matías N. Möller, Ana Denicola
doaj   +1 more source

Modulation of Myocardial Contraction by Peroxynitrite

Frontiers in Physiology, 2012
Peroxynitrite is a potent oxidant that is quickly emerging as a crucial modulator of myocardial function. This review will focus on the regulation of myocardial contraction by peroxynitrite during health and disease, with a specific emphasis on ...
Mark eKohr, Steve eRoof, Jay eZweier, Mark T Ziolo   +3 more
doaj   +1 more source

Hypoxia helps glioma to fight therapy [PDF]

, 2009
Despite major improvements in the surgical management the prognosis for patients bearing malignant gliomas is still dismal. Malignant gliomas are notoriously resistant to treatment and the survival time of patients is between 3-8 years for low-grade and
Amberger-Murphy, Verena
core   +1 more source

Proteomics of Nitrotyrosine: Integrating Mass Spectrometry and Immunodetection in Redox‐Driven Pathology

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Nitrooxidative stress, driven by excess reactive nitrogen species like peroxynitrite, contributes to the pathogenesis of many chronic diseases. Among its molecular footprints, 3‐nitrotyrosine (3NT) has emerged as a biologically relevant marker of protein nitration.
Brîndușa Alina Petre
wiley   +1 more source

The Ubiquity of the Reaction of the Labile Iron Pool That Attenuates Peroxynitrite-Dependent Oxidation Intracellularly

Biomolecules
Although the labile iron pool (LIP) biochemical identity remains a topic of debate, it serves as a universal homeostatically regulated and essential cellular iron source.
Gabriel Simonetti da Silva, Maria Beatriz Braghetto Hernandes, José Carlos Toledo Junior   +2 more
doaj   +1 more source

Nitrosative stress in human spermatozoa causes cell death characterized by induction of mitochondrial permeability transition-driven necrosis

Asian Journal of Andrology, 2018
Peroxynitrite is a highly reactive nitrogen species and a potent inducer of apoptosis and necrosis in somatic cells. Peroxynitrite-induced nitrosative stress has emerged as a major cause of impaired sperm function; however, its ability to trigger cell ...
Pamela Uribe, María E Cabrillana, Miguel W Fornés, Favián Treulen, Rodrigo Boguen, Vladimir Isachenko, Evgenia Isachenko, Raúl Sánchez, Juana V Villegas   +8 more
doaj   +1 more source