Results 121 to 130 of about 76,980 (312)

The Sooner, the Better: Neuroprotective Strategies in Fetuses With Congenital Heart Disease

Prenatal Diagnosis, EarlyView.
ABSTRACT Congenital heart disease (CHD) is the most frequent congenital malformation at birth and is associated with neurodevelopmental impairments. Alterations in cardiovascular physiology can lead to reduced cerebral blood perfusion and oxygenation, which negatively affects brain growth and maturation.
Maaike Nijman, Mirthe E. M. van der Meijden, Johannes M. P. J. Breur, Raymond Stegeman, Nicolaas J. G. Jansen, Mireille N. Bekker, Manon J. N. L. Benders, Nathalie H. P. Claessens   +7 more
wiley   +1 more source

Identification and quantification of flavonoids in Carica papaya leaf and peroxynitrite-scavenging activity

Asian Pacific Journal of Tropical Biomedicine, 2017
Objective: To characterize the types, contents, and peroxynitrite-scavenging activities of flavonoids in the leaf of Carica papaya (C. papaya). Methods: Chromatographic and spectroscopic techniques along with high performance liquid chromatography ...
Agung Nugroho, Hesty Heryani, Jae Sue Choi, Hee-Juhn Park   +3 more
doaj   +1 more source

Underwater Plasma‐Driven Decomposition of Tetramethylammonium Hydroxide (TMAH) Under Different Applied Field Strengths

Plasma Processes and Polymers, EarlyView.
Underwater plasma efficiently degrades TMAH via in situ generation of reactive oxygen and nitrogen species. An underwater plasma accelerates mass transfer and radical attack on the quaternary ammonium cation. Time‐resolved analyses show decreasing TOC and conversion of organic carbon toward inorganic species, with concomitant formation of NO3–/NH4+ at ...
Ki‐Taik Lee, Hana Lim, Sung Cheol Park, Jin‐Young Bae, Sung‐Min Kim   +4 more
wiley   +1 more source

Mechanisms of cell death pathway activation following drug-induced inhibition of mitochondrial complex I

Redox Biology, 2015
Respiratory complex I inhibition by drugs and other chemicals has been implicated as a frequent mode of mitochondria-mediated cell injury. However, the exact mechanisms leading to the activation of cell death pathways are incompletely understood.
Naoki Imaizumi, Kang Kwang Lee, Carmen Zhang, Urs A. Boelsterli   +3 more
doaj   +1 more source

Pharmacology and clinical drug candidates in redox medicine [PDF]

, 2015
SIGNIFICANCE Oxidative stress is suggested to be a disease mechanism common to a wide range of disorders affecting human health. However, so far, the pharmacotherapeutic exploitation of this, for example, based on chemical scavenging of pro-oxidant ...
Casas, Ana I, Cuadrado, Antonio, Dao, V Thao-Vi, Di Lisa, Fabio, Ghezzi, Pietro, Jaquet, Vincent, Kaludercic, Nina, Maghzal, Ghassan J, Robledinos-Anton, Natalia, Schmidt, Harald H H W, Seredenina, Tamara, Stocker, Roland   +11 more
core   +3 more sources

Recent Progress in the Development of Metal‐Based Radiosensitizations for Cancer Therapy: A Review

Rare Metals, EarlyView.
ABSTRACT Radiotherapy (RT) remains an indispensable means in cancer treatment; however, its therapeutic efficacy is often limited by tumor radioresistance and side effect of damage to healthy tissue. The advances in nanotechnology have propelled metal radiosensitizers to forefront of precision medicine.
Xiao‐Xia Wu, Ding‐Hu Zhang, Chuan Hu, Yi‐Nan Ding, Kun Chen, Yi Jiang, Jun Luo, Fei Cao, Wei‐Yuan Hao, Bin‐Yan Zhong, Jie Lin, Dong Xu, Jia‐Ping Zheng   +12 more
wiley   +1 more source

ANSID: a Solid-Phase Proteomic Approach for Identification and Relative Quantification of Aromatic Nitration Sites

Frontiers in Chemistry, 2016
Nitration of tyrosine and other aromatic amino acid residues in proteins occurs in the setting of inflammatory, neurodegenerative and cardiovascular diseases – importantly, this modification has been implicated in the pathogenesis of diverse diseases and
Tal eNuriel, Tal eNuriel, Julia eWhitehouse, Yuliang eMa, Emily eMercer, Emily eMercer, Neil eBrown, Steven S Gross   +7 more
doaj   +1 more source

Medical Gas Plasma Inactivates Adenoviruses via Capsid Oxidation

Small, EarlyView.
Oxidative modification of three adenoviral capsid proteins after gas plasma treatment. Schematic representation of the viral infection process, starting with the initial attachment of the virus via its fiber protein binding to the cellular receptors (CAR and/or CD46). In the secondary attachment step, the penton base binds to integrin structures on the
Anke Schmidt, Meike Heuser, Paul Schulan, Lea Miebach, Alice Martinet, Marcus Frank, Kristian Wende, Sander Bekeschus   +7 more
wiley   +1 more source

Activation of microglial NADPH oxidase is synergistic with glial iNOS expression in inducing neuronal death: a dual-key mechanism of inflammatory neurodegeneration

Journal of Neuroinflammation, 2005
Background Inflammation-activated glia are seen in many CNS pathologies and may kill neurons through the release of cytotoxic mediators, such as nitric oxide from inducible NO synthase (iNOS), and possibly superoxide from NADPH oxidase (NOX).
Brown Guy C, Mander Palwinder
doaj   +1 more source

Activation of TLR-9 Induces IL-8 Secretion through Peroxynitrite Signaling in Human Neutrophils [PDF]

, 2006
Levente József, Tarek Khreiss, Driss El Kebir, János G. Filep   +3 more
openalex   +1 more source